Product image of Abilify Maintena 400 (Aripiprazole) 400mg PFS supplied by GNH India

Abilify Maintena 400

Active Ingredient:
Aripiprazole
Form:
PFS
Brand:
Abilify Maintena

Abilify Maintena 400 (Aripiprazole PFS) 400mg

Aripiprazole, the active ingredient in Abilify Maintena 400, is an atypical antipsychotic presented as a 400mg pre-filled syringe (PFS) for intramuscular use. It is used in the treatment of schizophrenia and bipolar I disorder (maintenance therapy).

GNH India supplies Abilify Maintena 400 as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

Strength

400mg

Pack Size

1s

Storage

Ambient

Manufacturer / TM Owner

LUNDBECK (SCHWEIZ) AG

1
Pack/s
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Indications & Clinical Uses

Abilify Maintena 400 is an atypical antipsychotic used to manage mental health conditions. It is primarily indicated for the following conditions:

  • Schizophrenia: Helps manage symptoms such as hallucinations, delusions, and disorganized thinking.
  • Bipolar I disorder (maintenance therapy): Used to prevent the recurrence of manic or mixed episodes in adults with bipolar I disorder who have previously responded to aripiprazole treatment.

How It Works

  • Aripiprazole works by balancing brain chemicals called serotonin and dopamine. It acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A receptors. This mechanism helps to regulate mood and thought processes.

Side Effects

Abilify Maintena 400 may cause various side effects, ranging from common to serious or rare.

Common Side Effects

  • Nausea
  • Vomiting
  • Constipation
  • Headache
  • Dizziness
  • Anxiety
  • Insomnia
  • Injection site reactions

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome (NMS)
  • Tardive dyskinesia
  • High blood sugar
  • Weight gain
  • Seizures
  • Low white blood cell count

Precautions & Warnings

Abilify Maintena 400 should be used with caution and under medical supervision. Important precautions include:

  • Avoid becoming too hot or dehydrated: Drink plenty of water, limit exposure to heat and sun, and avoid overexertion.
  • Inform your healthcare provider about all medications you are taking to avoid potential interactions.
  • Monitor for signs of neuroleptic malignant syndrome (NMS) and tardive dyskinesia.
  • Use with caution in patients with diabetes or a history of high blood sugar.
  • Store below 30°C (86°F): Protect the syringe from light by storing in the original package until time of use.

Avoid Interactions

Abilify Maintena 400 may interact with other medications, which can affect its efficacy or increase the risk of side effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., carbamazepine, rifampin): Can decrease aripiprazole levels.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): Can increase aripiprazole levels.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: May cause additive effects on blood pressure.
  • Anticholinergics: May increase the risk of anticholinergic effects.
  • Drugs that prolong QT interval: May increase the risk of cardiac side effects.

Frequently Asked Questions

Abilify Maintena 400 is used to treat schizophrenia and bipolar I disorder (maintenance therapy). It helps manage symptoms such as hallucinations, delusions, and disorganized thinking in schizophrenia, and prevents the recurrence of manic or mixed episodes in bipolar I disorder.

Aripiprazole works by balancing brain chemicals called serotonin and dopamine. It acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A receptors. This mechanism helps to regulate mood and thought processes.

The usual dose of Abilify Maintena 400 is 400 mg administered once a month by intramuscular injection. The prescriber will determine the appropriate dose based on the patient's condition and response to the medication.

The safety of Abilify Maintena 400 during pregnancy or breastfeeding is not well established. It is important to discuss the potential risks and benefits with a healthcare provider before using this medication during pregnancy or while breastfeeding.

To order Abilify Maintena 400 from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will reply with pricing, availability, shipping, and the necessary import paperwork.

Abilify Maintena 400 is a long-acting injectable form of aripiprazole, which offers the convenience of monthly dosing. Compared to other antipsychotics, it has a unique mechanism of action and a different side effect profile. The choice of antipsychotic depends on individual patient needs and response to treatment.

Abilify Maintena 400 should be stored below 30°C (86°F) and protected from light by storing in the original package until time of use. It should not be frozen. Proper handling and storage are essential to maintain the medication's effectiveness.

Abilify Maintena 400 is administered by a healthcare provider as a once-a-month injection into the muscle (intramuscular). The injection is typically given in the arm or butt muscle, depending on the patient's body type.

The most serious risks to watch for with Abilify Maintena 400 include neuroleptic malignant syndrome (NMS), tardive dyskinesia, high blood sugar, weight gain, seizures, and low white blood cell count. Patients should be monitored for these potential side effects.

Abilify Maintena 400 should not be used by individuals who are allergic to aripiprazole or any of its components. It should also be used with caution in patients with certain medical conditions, such as diabetes, high blood pressure, or a history of seizures. Always consult a healthcare provider before starting this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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