Koortslipcrème Aciclovir Da (Aciclovir)

Aciclovir is an antiviral agent used to manage infections caused by herpes simplex virus on the skin and mucous membranes.

• Herpes labialis (cold sores): shortens lesion duration, reduces pain and accelerates healing.
• Localized herpes simplex infections: limits viral replication and promotes lesion resolution.
• Genital herpes (localized lesions): alleviates symptoms and supports faster recovery.

• Aciclovir is a nucleoside analogue that is phosphorylated by viral thymidine kinase and subsequently converted to its triphosphate form. The triphosphate competitively inhibits viral DNA polymerase, halting viral DNA chain elongation and preventing replication of herpes simplex virus in infected cells.

Topical aciclovir is generally well tolerated, but local reactions may occur.

Common Side Effects

• Mild skin irritation: redness or discomfort at the application site.
• Burning or stinging sensation: transient feeling during or after application.
• Itching: occasional pruritus around treated area.
• Dryness: slight desiccation of the skin.
• Redness: mild erythema localized to the cream area.
• Peeling: superficial skin flaking.

Serious or Rare Side Effects

• Allergic contact dermatitis: rash, swelling, or blistering.
• Severe skin reaction: signs of Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Systemic hypersensitivity: rare anaphylactic signs such as difficulty breathing.
• Persistent ulceration: worsening of lesions despite treatment.
• Secondary infection: bacterial superinfection of the lesion.

When using Koortslipcrème Aciclovir Da, consider the following safety measures.

• Avoid application on broken skin: limit use to intact lesions only.
• Known hypersensitivity: do not use if the patient has a documented allergy to aciclovir.
• Pregnancy considerations: consult a healthcare professional before use, as safety data are limited.
• Eye protection: keep the product away from eyes and mucous membranes.
• Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Topical aciclovir may interact with other systemic or topical agents.

Major Interactions (Avoid)

• Systemic aciclovir: concurrent use can increase total drug exposure and risk of toxicity.
• Probenecid: may raise systemic aciclovir levels if absorbed.

Moderate Interactions (Monitor Closely)

• Topical corticosteroids: may mask local irritation, reducing early detection of adverse reactions.
• Other topical antivirals: concurrent use could diminish individual efficacy.
• Nephrotoxic agents: monitor renal function if systemic absorption is suspected.