Koortslipcrème Aciclovir Etos (Aciclovir)

Aciclovir is an antiviral agent used to treat infections caused by the herpes simplex virus affecting the oral area.

• Herpes simplex labialis (cold sores): reduces lesion duration and promotes faster healing.
• Herpes simplex lip infection: limits viral replication and alleviates associated pain and swelling.
• Recurrent herpes labialis outbreaks: helps manage and shorten the course of repeated episodes.
• Primary herpes simplex infection of the lip: decreases severity of the initial outbreak.

• Aciclovir is selectively taken up by cells infected with herpes simplex virus, where viral thymidine kinase phosphorylates it to aciclovir monophosphate. Subsequent cellular kinases convert it to the active triphosphate form, which competitively inhibits viral DNA polymerase, terminating DNA chain elongation and preventing viral replication without significantly affecting host DNA synthesis. The drug accumulates preferentially in infected cells, providing targeted antiviral activity while sparing uninfected tissue.

Topical aciclovir cream may cause local skin reactions, most of which are mild and transient.

Common Side Effects

• Mild skin irritation: redness or soreness at the application site.
• Burning sensation: temporary warmth or tingling where the cream is applied.
• Itching: occasional pruritus around the treated area.
• Dryness: slight dryness or flaking of the skin.
• Stinging sensation: brief sharp feeling after application.
• Erythema: mild redness extending beyond the lesion.
• Swelling: minor edema at the site.

Serious or Rare Side Effects

• Allergic contact dermatitis: rash, swelling, or hives indicating hypersensitivity.
• Severe skin reactions: rare events such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Systemic absorption leading to renal toxicity: extremely uncommon but reported with extensive use.

When using Koortslipcrème Aciclovir Etos, follow these precautionary measures to ensure safe and effective treatment.

• Application: apply a thin layer to the affected area as directed by a healthcare professional.
• Avoid on extensive broken skin: do not use on large areas of damaged skin beyond the lesions.
• Allergy: discontinue use if signs of hypersensitivity such as rash or swelling appear.
• Pregnancy: safety not established; consult a physician before use during pregnancy.
• Children: use only under medical supervision, especially in young children.
• Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Aciclovir may interact with certain systemic medications or topical agents, affecting its efficacy or safety.

Major Interactions (Avoid)

• Systemic aciclovir: concurrent use may increase systemic exposure and risk of toxicity.
• Nephrotoxic drugs (e.g., aminoglycosides, NSAIDs): may heighten risk of renal impairment when combined.

Moderate Interactions (Monitor Closely)

• Topical corticosteroids: may reduce antiviral effectiveness of the cream.
• Immunosuppressants: may alter healing response and increase infection risk.
• Other topical antivirals: overlapping use can lead to unnecessary duplication of therapy.