ACTILYSE 50MG INJECTION - Alteplase(50mg)

Storage/Handling:

Store in room temperature below 25°C away from sunlight.

Uses of ACTILYSE 50MG INJECTION - Alteplase(50mg):

1. Acute Ischemic Stroke (AIS) (blood supply to part of the brain is interrupted or reduced)

2. Acute Myocardial Infarction (AMI) to reduce mortality and incidence of heart failure.

3. Acute Massive Pulmonary Embolism (PE) (blood clots in the lungs)

Product Introduction:

Actilyse 50mg Injection is classified as a thrombolytic medication and is used to treat various medical conditions, such as Acute Ischemic Stroke (AIS), Acute Myocardial Infarction (AMI), and Acute Massive Pulmonary Embolism (PE). It effectively reduces mortality and incidence of heart failure by dissolving blood clots that obstruct blood flow to the affected tissue.

To administer Actilyse 50mg Injection, a doctor injects it directly into a vein as soon as possible after the first signs of a heart attack, stroke, or pulmonary embolism are observed. Your vital signs, such as breathing, blood pressure, and oxygen levels, will be closely monitored during and after the treatment. Additionally, you may be given another medication to prevent the formation of new blood clots.

Before taking Actilyse 50mg Injection, inform your doctor of any allergies and medications you are currently using. Additionally, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The use of this medication may be affected by other medical conditions, such as active internal bleeding, recent intracranial or intraspinal surgery, serious head trauma, intracranial conditions that may increase the risk of bleeding, bleeding diathesis, current severe uncontrolled hypertension, current intracranial hemorrhage, subarachnoid hemorrhage, and history of recent stroke. It is recommended to avoid alcohol consumption during Actilyse 50mg Injection therapy.

Actilyse 50mg Injection may not be suitable for everyone, and there is a long list of medical conditions where it should not be administered. Your healthcare team will require detailed knowledge of your medical history before giving you this medication.

Benefits of ACTILYSE 50MG INJECTION - Alteplase(50mg):

Actilyse 50 mg Injection is a crucial medication that aids in preventing the formation of dangerous blood clots in the blood vessels, thereby decreasing the risk of Acute Ischemic Stroke (AIS) by dissolving hazardous blood clots that can cause heart attack and Acute Myocardial Infarction (AMI), subsequently reducing the future risk of mortality and the occurrence of heart failure. Additionally, it is effective in treating acute massive pulmonary embolism (PE) through lysis, as it dissolves blood clots in the lungs that obstruct blood flow to the affected tissue.

Side Effects of ACTILYSE 50MG INJECTION - Alteplase(50mg):

These are major and minor side effects of Actilyse 50mg Injection.

1. Bleeding
2. Nausea
3. Difficulty in breathing
4. Vomiting
5. Headache & confusion
6. Injection site reactions

Drug Interactions:

Drug-Drug Interactions: The medication shows severe reaction with the following-
Enoxaparin
Apixaban
Warfarin
Abciximab

Drug-Food Interactions: No information is available.

Drug-Disease Interactions: The medication is not at all recommended for the patients with the high risk of internal active bleeding or genetic bleeding disorders.

How ACTILYSE 50MG INJECTION - Alteplase(50mg) Works:

Actilyse has alteplase as its active ingredient and is classified as a thrombolytic agent medication. Its mechanism of action involves dissolving clots within blood vessels, thus restoring blood flow to the affected tissue. This prevents tissue death and enhances overall outcomes.

How To Use ACTILYSE 50MG INJECTION - Alteplase(50mg):

The Actilyse 50mg Injection is not meant to be self administered. A healthcare professional will be appointed to give the medication.

Safety Instructions For ACTILYSE 50MG INJECTION - Alteplase(50mg):

ALCOHOL Consult the Doctor Actilyse 50mg Injection is not known to have any interactions with alcohol however it is advisable to consult your doctor.  PREGNANCY Caution It is better to inform your doctor if you are pregnant or planning pregnancy before receiving Actilyse 50mg Injection as it may be harmful. Your doctor will assess the benefits and the risks before prescribing. BREAST FEEDING Safe if Prescribed Few studies have known to not cause any harm to the baby but it is better to inform the doctor that you are breastfeeding before receiving Actilyse 50mg Injection & let him assess the benefits and the risks before prescribing the medication. LIVER Safe if Prescribed There is very limited information available on the possible side effects of Actilyse 50mg Injection on liver. It is recommended to consult the doctor. KIDNEY Safe if Prescribed Actilyse 50mg Injection has no effects on kidney and may not require for changes in its adjustment. However, Inform your doctor & he may adjust based on your condition. Driving Not Relevant The medicine is given to hospitalised patients only so this point has no relevance. CHILDREN Unsafe Actilyse 50mg Injection should be kept out of the reach of children.

Habit Forming

No

Diet & Lifestyle Advices:

1. Adopting a low-cholesterol diet and a regular exercise routine can complement the treatment with Actilyse 50mg Injection effectively.

2. Opt for freshly prepared home-cooked meals and avoid processed or packaged foods that may contain hidden sugar and extra calories.

3. Replacing saturated fats with unsaturated fats in your diet can significantly reduce total cholesterol and LDL cholesterol (bad cholesterol).

4. Foods such as avocados, olive oil, fatty fish, and nuts are rich in heart-healthy unsaturated fats and should be consumed regularly.

5. Include foods in your diet that are enriched with fats like fish oils, polyunsaturated oils, and omega-3 fatty acids as they are good for heart health.

6. Quit smoking and avoid excessive alcohol consumption for better heart health.

Remember:

1. To minimize the risk of bleeding, it is advisable to avoid injuries and sharp objects while receiving Actilyse 50mg Injection. Inform your doctor if you have peptic ulcers or injuries.

2. Actilyse 50mg Injection should be administered as soon as possible, preferably within 12 hours after a heart attack and within 4.5 hours after the onset of stroke.

3. If you experience nosebleeds, gum bleeding, black or tarry stools, or unusual bruising after receiving Actilyse 50mg Injection, inform your doctor immediately.

4. To prevent the recurrence of a heart attack or stroke, do not discontinue the medications prescribed after receiving Actilyse 50mg Injection.

5. Actilyse 50mg Injection is not suitable for everyone. If you have a history of head injury, brain or spinal cord surgery, or any active bleeding in your body, you will not be given Actilyse 50mg Injection. Your medical history will be thoroughly evaluated by your healthcare team before administering this medication.

6. Patients with severe uncontrolled hypertension are advised not to use Actilyse 50mg Injection due to the risk of exacerbating their condition.

FAQs:

1. What is Actilyse 50 mg Injection used for?

Actilyse 50 mg Injection is used as a thrombolytic agent to dissolve unwanted blood clots. It is prescribed for the treatment of stroke (caused by blood clots blocking the blood vessels), blood clots in the lungs (pulmonary embolism), and also for the prevention of heart attack.

2. Is Actilyse 50mg Injection safe to use?

Actilyse 50mg Injection is safe if used in the dose and duration advised by your doctor. It is important to take it exactly as directed and not skip any dose. Follow your doctor's instructions carefully and let them know if any of the side effects bother you.

3. Where is Actilyse 50 mg Injection injected?

Actilyse 50 mg Injection is injected into a vein and is administered by a healthcare professional in a hospital or clinic setting.

4. Does Actilyse 50 mg Injection cause blood clots?

No, Actilyse 50 mg Injection does not cause blood clots. It is a thrombolytic drug that helps the body produce a substance to dissolve unwanted blood clots.

5. Is Actilyse 50mg Injection an emergency drug?

Yes, Actilyse 50mg Injection is an emergency drug used in the treatment of myocardial infarction, ischemic stroke, and pulmonary emboli.

6. What medicines should be avoided while taking Actilyse 50mg Injection?

Several medicines can interact with Actilyse 50mg Injection. If you are already taking Actilyse 50mg Injection, do not take any other medicine without consulting your doctor.

7. Can Actilyse 50mg Injection increase the risk of bleeding?

Yes, Actilyse 50mg Injection can increase the risk of bleeding. It is important to be careful while doing activities that may cause an injury or bleeding. Notify your doctor immediately if you experience abnormal bruising or bleeding.