Product image of Adcetris Tk (Brentuximab Vendotin) 50mg Vials supplied by GNH India

Adcetris Tk

Active Ingredient:
Brentuximab Vendotin
Form:
Vials
Brand:
Adcetris
Origin:
Italy

Adcetris Tk (Brentuximab Vendotin Vials) 50mg

Brentuximab vedotin, the active ingredient in Adcetris Tk, is an antibody-drug conjugate presented as a 50mg vial for intravenous use. It is used to treat certain types of lymphoma, including classical Hodgkin lymphoma and systemic anaplastic large cell lymphoma. GNH India supplies Adcetris Tk as a licensed, GDP-compliant international pharmaceutical supplier serving oncology centers worldwide.

Adcetris Tk is a targeted therapy designed to deliver a cytotoxic agent directly to CD30-positive tumor cells, minimizing damage to healthy cells. This makes it a valuable treatment option for patients with specific types of lymphoma who have not responded to other treatments.

Strength

50mg

Pack Size

1s

Storage

2-8°

Manufacturer / TM Owner

Takeda Pharma

1
Pack/s
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Indications & Clinical Uses

Adcetris Tk is used to treat various types of lymphoma by targeting CD30-positive cells. It is indicated for the following conditions:

  • Classical Hodgkin lymphoma: Used in patients who have relapsed or are refractory to other treatments.
  • Systemic anaplastic large cell lymphoma: Effective in treating patients with this type of lymphoma.
  • Primary mediastinal large B-cell lymphoma: Approved for use in certain cases of this lymphoma type.
  • Other CD30-positive lymphomas: May be used in other lymphomas that express the CD30 protein as approved by regulatory authorities.

How It Works

  • Brentuximab vedotin works by targeting the CD30 protein, which is commonly found on the surface of certain cancer cells. The monoclonal antibody component of the drug binds specifically to CD30, and once internalized, the monomethyl auristatin E (MMAE) component is released. MMAE disrupts the cell's microtubules, leading to cell cycle arrest and apoptosis, thereby killing the cancer cells.

Side Effects

Adcetris Tk can cause various side effects, ranging from common to serious. Common side effects include:

Common Side Effects

  • Fatigue
  • Nausea and vomiting
  • Peripheral neuropathy
  • Diarrhea
  • Fever
  • Constipation
  • Hair loss
  • Decreased appetite

Serious or Rare Side Effects

  • Severe infections
  • Neutropenia (low white blood cell count)
  • Anemia (low red blood cell count)
  • Thrombocytopenia (low platelet count)
  • Severe allergic reactions
  • Progressive multifocal leukoencephalopathy (PML)
  • Peripheral neuropathy leading to severe disability

Precautions & Warnings

Adcetris Tk should be used with caution and under the supervision of a healthcare professional. Important precautions include:

  • Pregnancy: Avoid use during pregnancy due to potential risks to the fetus.
  • Breastfeeding: Avoid breastfeeding while using this medication.
  • Infections: Monitor for signs of infection and manage promptly.
  • Neutropenia: Regularly monitor blood cell counts.
  • Peripheral Neuropathy: Monitor for symptoms of nerve damage.
  • Hepatotoxicity: Monitor liver function regularly.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Adcetris Tk can interact with other medications, which may affect its efficacy or increase the risk of side effects. Major and moderate interactions include:

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors: Can increase the risk of adverse effects.
  • Strong CYP3A4 inducers: Can decrease the efficacy of the medication.
  • Live vaccines: Avoid concurrent use due to increased risk of infections.
  • Other myelosuppressive agents: Increased risk of neutropenia.

Moderate Interactions (Monitor Closely)

  • Antineoplastic agents: Increased risk of side effects.
  • Immunosuppressive agents: Increased risk of infections.
  • Anticonvulsants: May affect the metabolism of the medication.

Frequently Asked Questions

Adcetris Tk is used to treat certain types of lymphoma, including classical Hodgkin lymphoma and systemic anaplastica large cell lymphoma. It is specifically designed to target CD30-positive cancer cells, making it effective in patients who have not responded to other treatments.

Brentuximab Vedotin works by targeting the CD30 protein found on the surface of certain cancer cells. The monoclonal antibody component binds to CD30, and once internalized, the monomethyl auristatin E (MMAE) component is released. MMAE disrupts the cell's microtubules, leading to cell cycle arrest and apoptosis, thereby killing the cancer cells.

The dose of Adcetris Tk is determined by a healthcare professional based on the patient's condition and response to treatment. It is typically administered as an intravenous infusion every three weeks, but the exact dosage and schedule should be determined by the prescribing physician.

Adcetris Tk should be avoided during pregnancy due to potential risks to the fetus. It is also recommended to avoid breastfeeding while using this medication. Patients should consult their healthcare provider for personalized advice.

To order Adcetris Tk from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will then reply with pricing, availability, shipping, and the necessary import paperwork.

Adcetris Tk is a targeted therapy that specifically binds to CD30-positive cancer cells, minimizing damage to healthy cells. Compared to traditional chemotherapy, it may have a different side effect profile and may be more effective in certain types of lymphoma. The choice of treatment depends on the patient's specific condition and response to therapy.

Adcetris Tk should be stored at 2-8°C, kept refrigerated, protected from light, and not frozen or shaken. Proper storage and handling are crucial to maintain the medication's efficacy and safety. Always follow the storage instructions provided by the manufacturer.

Adcetris Tk is administered as an intravenous infusion by a healthcare professional. The infusion typically takes about 30 minutes, and the frequency of administration is determined by the prescribing physician based on the patient's condition and response to treatment.

The most serious risks associated with Adcetris Tk include severe infections, neutropenia, anemia, thrombocytopenia, severe allergic reactions, progressive multifocal leukoencephalopathy (PML), and peripheral neuropathy leading to severe disability. Patients should be closely monitored for these risks during treatment.

Adcetris Tk should not be used by patients who are allergic to Brentuximab Vedotin or any of its components. It should also be avoided during pregnancy and breastfeeding. Patients with certain medical conditions or those taking specific medications that interact with Adcetris Tk should consult their healthcare provider before starting treatment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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