Adelone (Prednisolone Sodium Phosphate)

Adelone is used to treat inflammatory and allergic conditions of the eye. It is particularly effective in managing conditions such as:

• Allergic conjunctivitis: Reduces swelling, redness, and itching caused by allergic reactions in the conjunctiva.
• Uveitis: Helps in reducing inflammation in the uvea, the middle layer of the eye.
• Iritis: Alleviates inflammation in the iris, the colored part of the eye.
• Post-operative ocular inflammation: Used to reduce inflammation following eye surgeries.
• Episcleritis: Treats inflammation of the episclera, the layer covering the sclera.
• Keratitis: Reduces inflammation in the cornea, the clear front part of the eye.

• Prednisolone sodium phosphate works by binding to intracellular glucocorticoid receptors, which then modulate gene transcription. This process suppresses the production of inflammatory cytokines and reduces the activation of immune cells, leading to a decrease in inflammation and immune response in the eye.

Adelone may cause several side effects, ranging from common to serious. Common Side Effects:

• Temporary stinging or burning upon application.
• Blurred vision or increased sensitivity to light.
• Mild irritation or redness of the eye.
• Temporary discomfort or itching.

Serious or Rare Side Effects

• Increased intraocular pressure, which can lead to glaucoma.
• Development of cataracts with prolonged use.
• Secondary eye infections due to immunosuppression.
• Thinning of the cornea or sclera with long-term use.
• Allergic reactions, including rash or swelling around the eyes.

Adelone should be used with caution and under the supervision of a healthcare professional. Important precautions include:

• Avoid prolonged use: Prolonged use can increase the risk of side effects such as glaucoma and cataracts.
• Monitor for infections: Use with caution in patients with a history of eye infections.
• Avoid in viral or fungal infections: Do not use in cases of viral or fungal eye infections unless under strict medical supervision.
• Inform healthcare provider: Inform your healthcare provider if you have a history of glaucoma or cataracts.
• Store below 25°C: Keep in the original pack, protect from light and moisture.

Adelone may interact with other medications, potentially altering their effects or increasing the risk of side effects. Major Interactions (Avoid):

• Other corticosteroids: Concurrent use with other corticosteroids can increase the risk of side effects.
• Immunosuppressants: May enhance the immunosuppressive effects, increasing the risk of infections.

Moderate Interactions (Monitor Closely)

• Anticoagulants: May increase the risk of bleeding or bruising.
• Antidiabetic agents: May affect blood sugar control, requiring close monitoring.
• Antihypertensives: May alter blood pressure control, necessitating frequent monitoring.