Andexxa - 5s (Andexanet Alfa Vials) 200 mg/20mL

Andexxa - 5s is a factor Xa inhibitor reversal agent used to manage anticoagulation in patients treated with apixaban or rivaroxaban.

• Uncontrolled bleeding: Reverses the anticoagulant effects of apixaban or rivaroxaban in patients experiencing life-threatening or uncontrolled bleeding.
• Emergency surgery: Facilitates rapid reversal of anticoagulation in patients requiring urgent or emergency surgery who are on factor Xa inhibitors.
• Invasive procedures: Provides a means to manage anticoagulation in patients undergoing invasive procedures while on factor Xa inhibitors.

• Andexanet alfa is a recombinant modified human factor Xa decoy protein that binds factor Xa inhibitors (e.g., apixaban, rivaroxaban, edoxaban) with high affinity. By sequestering these inhibitors, it restores normal hemostasis by allowing native factor Xa to function properly, thereby reversing the anticoagulant effects.

Andexxa - 5s, like all medications, can cause side effects.

Common Side Effects

• Nausea: Feeling sick to the stomach.
• Vomiting: Expelling stomach contents through the mouth.
• Fever: Elevated body temperature.
• Headache: Pain or discomfort in the head or neck.
• Flushing: Redness or warmth in the skin.
• Chest pain: Discomfort or pain in the chest area.

Serious or Rare Side Effects

• Thromboembolic events: Blood clots that can lead to serious conditions such as stroke or heart attack.
• Allergic reactions: Severe allergic responses that may include difficulty breathing, swelling, or rash.
• Anaphylaxis: A severe, life-threatening allergic reaction requiring immediate medical attention.
• Ischemic events: Reduced blood flow to organs or tissues, which can cause damage or dysfunction.

Andexxa - 5s should be used with caution and under the supervision of a healthcare professional.

• Monitor for thromboembolic events: Regularly check for signs of blood clots.
• Allergic reactions: Be aware of potential allergic responses and seek immediate medical attention if they occur.
• Pregnancy: Use with caution in pregnant women, as the safety has not been established.
• Breastfeeding: Avoid use in breastfeeding women unless necessary, as the safety has not been established.
• Pre-existing conditions: Use with caution in patients with pre-existing conditions that may be exacerbated by the medication.
• Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Andexxa - 5s may interact with other medications, which can affect its efficacy or increase the risk of side effects.

Major Interactions (Avoid)

• Anticoagulants: Avoid concurrent use with other anticoagulants, as it may increase the risk of bleeding.
• Antiplatelet agents: Avoid concurrent use with antiplatelet agents, as it may increase the risk of bleeding.
• Thrombolytics: Avoid concurrent use with thrombolytics, as it may increase the risk of bleeding.

Moderate Interactions (Monitor Closely)

• NSAIDs: Monitor closely when used with non-steroidal anti-inflammatory drugs, as it may increase the risk of bleeding.
• SSRIs: Monitor closely when used with selective serotonin reuptake inhibitors, as it may increase the risk of bleeding.
• Other medications that affect coagulation: Monitor closely when used with other medications that affect coagulation, as it may increase the risk of bleeding.