Product image of Atorvastatin 20mg (Atorvastatin Calcium ) 20mg Tablet supplied by GNH India

Atorvastatin 20mg

Active Ingredient:
Atorvastatin Calcium
Form:
Tablet
Brand:
Atorvastatin 20mg
Origin:
USA

Atorvastatin 20mg (Atorvastatin Calcium Tablet) 20mg

Atorvastatin calcium, the active ingredient in Atorvastatin 20mg, is an HMG-CoA reductase inhibitor presented as a 20mg tablet for oral use. It is used to lower cholesterol levels and reduce the risk of cardiovascular events in adults and children aged 10 years and older with various forms of hyperlipidemia.

GNH India supplies Atorvastatin 20mg as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

Strength

20mg

Pack Size

100s

Storage

Below 25°C

Manufacturer / TM Owner

Major Pharmaceuticals

1
Pack/s
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Indications & Clinical Uses

Atorvastatin 20mg is a lipid-lowering agent used to manage cholesterol levels and reduce cardiovascular risk.

  • Hypercholesterolemia: Reduces elevated LDL cholesterol levels.
  • Primary prevention of cardiovascular disease: Lowers the risk of heart attack and stroke in individuals with multiple risk factors.
  • Secondary prevention of cardiovascular disease: Helps prevent recurrent cardiovascular events in patients with existing heart disease.
  • Mixed dyslipidemia: Treats a combination of high cholesterol and high triglycerides.
  • Familial hypercholesterolemia: Manages inherited conditions causing very high cholesterol levels.

How It Works

  • Atorvastatin calcium inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis. This action reduces hepatic cholesterol production and up-regulates LDL receptors, leading to increased clearance of LDL cholesterol from the bloodstream. The overall effect is a significant reduction in LDL cholesterol levels and a decrease in cardiovascular risk.

Side Effects

Atorvastatin 20mg may cause side effects, ranging from common to serious.

Common Side Effects

  • Nasopharyngitis: Common cold symptoms.
  • Arthralgia: Joint pain.
  • Diarrhea: Loose or watery stools.
  • Pain in extremity: Discomfort in arms or legs.
  • Urinary tract infection: Symptoms such as pain during urination.

Serious or Rare Side Effects

  • Myopathy and Rhabdomyolysis: Muscle pain, tenderness, or weakness, which can lead to severe muscle damage.
  • Immune-Mediated Necrotizing Myopathy: Severe muscle inflammation.
  • Hepatic Dysfunction: Liver damage, including elevated liver enzymes.
  • Increases in HbA1c and Fasting Serum Glucose Levels: Elevated blood sugar levels.

Precautions & Warnings

Atorvastatin 20mg should be used with caution and under medical supervision.

  • Monitor liver function: Regularly check liver enzymes before and during treatment.
  • Discontinue if myopathy is suspected: Stop the medication if muscle pain or weakness occurs.
  • Avoid in pregnancy: Atorvastatin is contraindicated in pregnancy due to potential harm to the fetus.
  • Use with caution in liver disease: Adjust dosage or avoid use in patients with liver impairment.
  • Monitor for rhabdomyolysis: Discontinue if markedly elevated creatine kinase levels occur.
  • Store at controlled room temperature: Keep at 20º to 25ºC (68º to 77ºF).

Avoid Interactions

Atorvastatin 20mg may interact with other medications, requiring careful monitoring.

Major Interactions (Avoid)

  • Fibrates: Increased risk of myopathy.
  • Niacin: Enhanced risk of muscle damage.
  • Erythromycin: Increased atorvastatin levels, leading to higher risk of side effects.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: May increase the risk of bleeding.
  • Digoxin: Increased digoxin levels, requiring monitoring.
  • Cyclosporine: Increased risk of myopathy and rhabdomyolysis.

Frequently Asked Questions

Atorvastatin 20mg is used to lower cholesterol levels and reduce the risk of cardiovascular events. It is indicated for hypercholesterolemia, primary and secondary prevention of cardiovascular disease, mixed dyslipidemia, and familial hypercholesterolemia. The medication works by inhibiting the enzyme HMG-CoA reductase, which reduces the production of cholesterol in the liver.

Atorvastatin calcium works by inhibiting HMG-CoA reductase, an enzyme involved in cholesterol synthesis. By blocking this enzyme, it reduces the production of cholesterol in the liver and increases the liver's ability to remove LDL cholesterol from the bloodstream. This leads to lower LDL cholesterol levels and a decreased risk of cardiovascular events.

The usual starting dose of Atorvastatin 20mg is 10 to 20 mg once daily, with a dosage range of 10 to 80 mg once daily. The prescriber will determine the appropriate dose based on the patient's cholesterol levels and overall health. Patients requiring a greater reduction in LDL cholesterol may start at a higher dose, such as 40 mg once daily.

Atorvastatin 20mg is contraindicated during pregnancy due to the potential risk of harm to the fetus. It should not be used by pregnant women or those planning to become pregnant. The safety of Atorvastatin during breastfeeding has not been established, and it is generally recommended to avoid its use in nursing mothers.

To order Atorvastatin 20mg from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will then provide pricing, availability, shipping details, and the necessary import paperwork.

Atorvastatin 20mg is a statin, a class of medications known for their effectiveness in lowering LDL cholesterol. Compared to other statins, Atorvastatin is highly potent and is often prescribed for patients requiring significant reductions in cholesterol levels. It is also used for both primary and secondary prevention of cardiovascular events, making it a versatile option for managing cholesterol.

Atorvastatin 20mg should be stored at controlled room temperature, between 20º to 25ºC (68º to 77ºF). Keep the medication in its original packaging to protect it from moisture and light. Ensure that the tablets are stored out of reach of children and pets. Do not use the medication if the packaging is damaged or if the tablets appear discolored or damaged.

Atorvastatin 20mg is administered orally, once daily, with or without food. The medication can be taken at any time of the day, but it is important to take it consistently at the same time each day to maintain steady levels in the blood. The prescriber will determine the appropriate dose and duration of treatment based on the patient's cholesterol levels and overall health.

The most serious risks associated with Atorvastatin 20mg include myopathy and rhabdomyolysis, which can lead to severe muscle damage and kidney failure. Patients should be monitored for muscle pain, tenderness, or weakness, and the medication should be discontinued if these symptoms occur. Other serious risks include liver dysfunction and immune-mediated necrotizing myopathy.

Atorvastatin 20mg should not be used by individuals with known hypersensitivity to Atorvastatin or any of its components. It is also contraindicated in pregnant women and those with active liver disease. Patients with a history of muscle disorders or those taking medications that increase the risk of myopathy should use Atorvastatin with caution and under close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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