Product image of Nefúði, Dreifa (Azelastine Hydrochloride, Fluticasone Propionate) supplied by GNH India

Nefúði, Dreifa

Active Ingredient:
Azelastine Hydrochloride, Fluticasone Propionate
Origin:
EU

Nefúði, Dreifa (Azelastine Hydrochloride, Fluticasone Propionate)

Azelastine hydrochloride, the active ingredient in Nefúði, Dreifa, is an antihistamine presented as a nasal spray for intranasal use. It is combined with fluticasone propionate, a corticosteroid, to treat allergic rhinitis in patients who need both antihistamine and anti‑inflammatory action.

GNH India supplies Nefúði, Dreifa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Nefúði, Dreifa combines azelastine hydrochloride and fluticasone propionate to treat allergic rhinitis, an IgE‑mediated nasal inflammation.

  • Allergic rhinitis: reduces nasal congestion, itching, sneezing and rhinorrhoea.
  • Seasonal allergic rhinitis: alleviates symptoms triggered by pollen or other seasonal allergens.
  • Perennial allergic rhinitis: controls year‑round nasal inflammation caused by indoor allergens.

How It Works

  • Azelastine hydrochloride selectively blocks H1‑histamine receptors, preventing histamine‑induced vasodilation and sensory nerve activation in the nasal mucosa. Fluticasone propionate binds glucocorticoid receptors, altering gene transcription to suppress pro‑inflammatory cytokines, reduce edema, and inhibit recruitment of inflammatory cells, providing a synergistic anti‑allergic effect when administered intranasally.

Side Effects

Nefúði, Dreifa may cause local and systemic adverse reactions.

Common Side Effects

  • Nasal irritation or burning sensation.
  • Headache.
  • Bitter taste.
  • Epistaxis (nosebleed).
  • Cough.
  • Throat irritation.

Serious or Rare Side Effects

  • Nasal septal perforation.
  • Severe allergic reaction (anaphylaxis).
  • Vision changes or increased intra‑ocular pressure.
  • Adrenal suppression with prolonged high‑dose use.
  • Secondary infection of the nasal mucosa.

Precautions & Warnings

Before using Nefúði, Dreifa, consider the following precautions.

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a physician.
  • Concomitant intranasal corticosteroids: avoid to reduce systemic exposure.
  • Glaucoma or cataract: monitor intra‑ocular pressure regularly.
  • Children and adolescents: follow local prescribing guidelines.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Nefúði, Dreifa can interact with other medicines; monitor as indicated.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase fluticasone levels.
  • Live vaccines: may reduce vaccine efficacy.
  • Concurrent use of other intranasal corticosteroids: risk of systemic corticosteroid effects.

Moderate Interactions (Monitor Closely):\n- Other antihistamines: possible additive sedation.

  • Beta‑blockers: may mask symptoms of severe allergic reactions.
  • Alcohol: may increase nasal irritation or dryness.

Frequently Asked Questions

Nefúði, Dreifa is a combined intranasal formulation of azelastine hydrochloride and fluticasone propionate indicated for the relief of symptoms associated with allergic rhinitis, including nasal congestion, itching, sneezing, and runny nose.

Azelastine hydrochloride acts as a selective H1‑histamine receptor antagonist. By blocking these receptors in the nasal mucosa, it prevents histamine‑mediated vasodilation and sensory nerve activation, thereby reducing itching, sneezing, and watery discharge.

The prescribed dose of Nefúði, Dreifa is determined by the treating healthcare professional based on the patient’s age, severity of symptoms, and clinical response. Patients should follow the specific instructions provided by their prescriber.

Safety in pregnancy and lactation has not been fully established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using this medication.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nefúði, Dreifa combines an antihistamine (azelastine) with a corticosteroid (fluticasone) in a single spray, offering both rapid symptom relief and anti‑inflammatory action. Single‑agent sprays contain either an antihistamine or a steroid, which may require separate products to achieve comparable efficacy.

Store the nasal spray at room temperature, below 25 °C, in the original packaging. Keep it away from moisture and direct sunlight to maintain product stability and potency.

The spray is administered intranasally. The patient tilts the head slightly forward, inserts the nozzle into one nostril, and sprays the prescribed number of sprays while breathing in gently. The process is repeated in the other nostril if directed by the prescriber.

Serious risks include nasal septal perforation, severe allergic reactions such as anaphylaxis, and potential adrenal suppression with prolonged high‑dose use. Patients should seek immediate medical attention if they experience unusual bleeding, vision changes, or signs of a severe allergic response.

Individuals with known hypersensitivity to azelastine, fluticasone, or any excipients in the formulation should avoid using this product. It is also contraindicated in patients who require other intranasal corticosteroids concurrently without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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