Liorésal (Baclofen)

Baclofen activates GABA_B receptors in the spinal cord, inhibiting the release of excitatory neurotransmitters and dampening spinal reflex activity. This results in reduced muscle tone and fewer involuntary contractions.

The appropriate dose of Liorésal is individualized by the prescribing clinician based on the patient’s condition, response, and tolerability. Dosage adjustments are made according to clinical guidelines and patient needs.

Liorésal is classified as Pregnancy Category C, indicating that risk cannot be ruled out. It should only be used if the potential benefit justifies the potential risk to the fetus. Baclofen is excreted in breast milk, so caution is advised while breastfeeding.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Baclofen, the active ingredient in Liorésal, is a GABA_B receptor agonist, whereas alternatives such as tizanidine act on α2‑adrenergic receptors. Baclofen is often preferred for its oral availability and well‑characterized efficacy, but individual response and side‑effect profiles may guide the choice of therapy.

Liorésal tablets should be stored at ambient temperature, below 25 °C, in their original packaging. Protect them from moisture, direct sunlight and excessive heat to maintain product stability.

Liorésal is taken orally as a tablet. Patients should swallow the tablet whole with water, following the dosing schedule prescribed by their healthcare professional. It can be taken with or without food, unless otherwise directed.

Serious risks include seizures, severe hypotension, respiratory depression, hallucinations, allergic reactions such as anaphylaxis, and cardiac arrhythmias. Patients should seek immediate medical attention if any of these symptoms occur.

Liorésal is contraindicated in patients with known hypersensitivity to baclofen or any tablet excipients. Caution is also advised for individuals with severe renal or hepatic impairment, uncontrolled epilepsy, or those who are pregnant without a clear therapeutic indication.