Product image of Bedaquiline Fumarate 100 mg Tablet supplied by GNH India

Bedaquiline Fumarate

Active Ingredient:
Bedaquiline Fumarate
Form:
Tablet
Brand:
BQNAT
Origin:
india

Bedaquiline Fumarate (Tablet) 100 mg

Bedaquiline fumarate, the active ingredient in BQNAT, is a diarylquinoline antibiotic presented as a 100 mg tablet for oral use. It is used in the treatment of multidrug-resistant tuberculosis (MDR-TB). GNH India supplies BQNAT as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

Bedaquiline fumarate is a critical medication in the fight against MDR-TB, a severe form of tuberculosis that resists conventional antibiotics. Its unique mechanism of action makes it a valuable tool in global TB control programs.

Strength

100 mg

Pack Size

1*188s

Storage

Ambient

Manufacturer / TM Owner

NATCO PHARMA LTD

1
Pack/s
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Indications & Clinical Uses

BQNAT is primarily used in the treatment of multidrug-resistant tuberculosis (MDR-TB).

  • Multidrug-resistant tuberculosis (MDR-TB): BQNAT is used to treat pulmonary tuberculosis caused by Mycobacterium tuberculosis that is resistant to other common anti-TB agents such as rifampin and isoniazid.
  • MDR-TB treatment regimens: BQNAT is often used in combination with other TB medicines to effectively manage and treat MDR-TB.
  • Severe TB cases: BQNAT is indicated for patients who have limited treatment options due to resistance to other anti-TB medications.

How It Works

  • Bedaquiline fumarate works by inhibiting mycobacterial ATP synthase, which is crucial for the survival of Mycobacterium tuberculosis. By depleting the bacterial cell's ATP, it halts energy production and leads to bacterial death. This mechanism makes it effective against strains of tuberculosis that have developed resistance to other antibiotics.

Side Effects

BQNAT may cause various side effects, ranging from mild to severe. Common side effects include:

Common Side Effects

  • Nausea: Feeling sick to the stomach.
  • Headache: Pain or discomfort in the head.
  • Joint pain: Discomfort or soreness in the joints.
  • Coughing up blood: Hemoptysis, which may indicate a serious condition.
  • Abdominal pain: Discomfort or pain in the stomach area.
  • Chest pain: Discomfort or pain in the chest.
  • Elevated liver enzymes: Indicating potential liver dysfunction.

Serious or Rare Side Effects

  • Severe liver toxicity: Can lead to liver damage or failure.
  • QT prolongation: A heart rhythm disorder that can be life-threatening.
  • Hypersensitivity reactions: Allergic reactions that can be severe.
  • Heart failure: Can occur in some patients, especially those with pre-existing heart conditions.

Precautions & Warnings

BQNAT should be used with caution and under strict medical supervision. Important precautions include:

  • Medical supervision: BQNAT should only be administered under the supervision of a healthcare professional experienced in the treatment of MDR-TB.
  • Liver function monitoring: Regular monitoring of liver function is essential due to the risk of liver toxicity.
  • Heart monitoring: Patients should be monitored for signs of QT prolongation and heart failure.
  • Pregnancy: The safety of BQNAT during pregnancy has not been established, and it should be used with caution.
  • Breastfeeding: It is not known whether BQNAT is excreted in breast milk, so caution is advised.
  • Store below 25°C: Keep in the original pack, protect from moisture.

Avoid Interactions

BQNAT may interact with other medications, which can affect its efficacy or increase the risk of side effects. Major interactions include:

Major Interactions (Avoid)

  • Rifampin: Can significantly reduce the effectiveness of BQNAT.
  • Strong CYP3A inducers: Can decrease the concentration of BQNAT in the body.
  • Strong CYP3A inhibitors: Can increase the concentration of BQNAT, leading to a higher risk of side effects.

Moderate Interactions (Monitor Closely)

  • Fluconazole: Can increase the concentration of BQNAT.
  • Verapamil: Can increase the concentration of BQNAT.
  • Amiodarone: Can increase the risk of QT prolongation when used with BQNAT.

Frequently Asked Questions

BQNAT is used in the treatment of multidrug-resistant tuberculosis (MDR-TB). It is specifically indicated for pulmonary tuberculosis caused by Mycobacterium tuberculosis that is resistant to other common anti-TB agents such as rifampin and isoniazid. BQNAT is often used in combination with other TB medicines to effectively manage and treat MDR-TB.

Bedaquiline fumarate works by inhibiting mycobacterial ATP synthase, which is crucial for the survival of Mycobacterium tuberculosis. By depleting the bacterial cell's ATP, it halts energy production and leads to bacterial death. This mechanism makes it effective against strains of tuberculosis that have developed resistance to other antibiotics.

The dosage of BQNAT should be determined by a healthcare professional based on the patient's condition and response to treatment. It is important to follow the prescribed dosage and not to adjust it without medical supervision.

The safety of BQNAT during pregnancy has not been established. It should be used with caution in pregnant women, and the potential benefits and risks should be carefully considered. Consult a healthcare professional for personalized advice.

To order BQNAT from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will reply with pricing, availability, shipping, and the import paperwork.

BQNAT is a diarylquinoline antibiotic specifically designed to treat multidrug-resistant tuberculosis (MDR-TB). It is used in combination with other TB medicines to effectively manage and treat MDR-TB. Compared to other TB medications, BQNAT has a unique mechanism of action that makes it effective against strains of tuberculosis that have developed resistance to other antibiotics.

BQNAT should be stored below 25°C, in the original pack, and protected from moisture. It is important to keep the medication out of reach of children and to follow the storage instructions provided by the manufacturer.

BQNAT is administered orally in the form of 100 mg tablets. The dosage and duration of treatment should be determined by a healthcare professional based on the patient's condition and response to treatment.

The most serious risks associated with BQNAT include severe liver toxicity, QT prolongation, and heart failure. Patients should be monitored for signs of these conditions, and any adverse effects should be reported to a healthcare professional immediately.

BQNAT should not be used by individuals who are allergic to Bedaquiline fumarate or any of the excipients in the formulation. It should be used with caution in patients with pre-existing liver or heart conditions, and the potential benefits and risks should be carefully considered.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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