Product image of Bendit 100mg (Bendamustine Hydrochloride) 100Mg Vials supplied by GNH India

Bendit 100mg

Active Ingredient:
Bendamustine Hydrochloride
Form:
Vials
Brand:
Bendit
Origin:
India

Bendit 100mg (Bendamustine Hydrochloride Vials) 100Mg

Bendamustine Hydrochloride, the active ingredient in Bendit 100mg, is an alkylating agent presented as a 100mg/vial injectable solution for intravenous use. It is used to treat chronic lymphocytic leukemia (CLL) and indolent non-Hodgkin lymphoma (NHL).

GNH India supplies Bendit 100mg as a licensed, GDP-compliant international pharmaceutical supplier serving oncology centers, hospitals, and pharmacies worldwide.

Strength

100Mg

Pack Size

1s

Storage

Ambient

Manufacturer / TM Owner

NATCO PHARMA LTD

1
Pack/s
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Indications & Clinical Uses

Bendit 100mg is an antineoplastic agent used in the treatment of various types of cancer, particularly those affecting the lymphatic system.

  • Chronic lymphocytic leukemia (CLL): Treats a type of blood and bone marrow cancer.
  • Indolent B-cell non-Hodgkin lymphoma (NHL): Treats a type of cancer that forms in the lymph system, part of the immune system.
  • Non-Hodgkin's Lymphoma (NHL): Used to treat cancer of the lymphatic system, including follicular lymphoma and mantle cell lymphoma (MCL).

How It Works

  • Bendamustine Hydrochloride is a bifunctional alkylating agent that forms electrophilic alkyl groups, which covalently bond to DNA. This results in intra- and inter-strand crosslinks between DNA bases, leading to cell death. It is active against both dividing and quiescent cells, although the exact mechanism of action is not fully understood.

Side Effects

Bendit 100mg may cause various side effects, ranging from common to serious or rare.

Common Side Effects

  • Fatigue
  • Nausea and vomiting
  • Diarrhea
  • Fever (pyrexia)
  • Anemia
  • Neutropenia
  • Thrombocytopenia
  • Rash
  • Stomatitis

Serious or Rare Side Effects

  • Severe infections due to low white blood cell counts
  • Severe allergic reactions
  • Skin cancer (non-melanoma)
  • Severe nausea and vomiting
  • Severe diarrhea
  • Severe fatigue
  • Severe skin reactions

Precautions & Warnings

Bendit 100mg should be used with caution and under medical supervision. Important precautions include:

  • Allergic reactions: Do not use if allergic to bendamustine or any of its components.
  • Bone marrow suppression: Regular blood tests are required to monitor blood cell counts.
  • Infections: Increased risk of infections due to low white blood cell counts.
  • Skin cancer: Increased risk of non-melanoma skin cancer.
  • Pregnancy and breastfeeding: Consult a doctor before use.
  • Store below 25°C: Keep in the original packaging, protect from moisture and light.

Avoid Interactions

Bendit 100mg may interact with other medications, which can affect its efficacy or increase the risk of side effects.

Major Interactions (Avoid)

  • Live vaccines: Avoid concurrent use due to increased risk of infections.
  • Other myelosuppressive drugs: Increased risk of severe bone marrow suppression.
  • Drugs metabolized by CYP1A2: Potential for increased toxicity.

Moderate Interactions (Monitor Closely)

  • Immunosuppressive drugs: Increased risk of infections and bone marrow suppression.
  • Anticancer drugs: Increased risk of side effects and toxicity.
  • Drugs that cause nausea and vomiting: May exacerbate gastrointestinal side effects.

Frequently Asked Questions

Bendit 100mg is used to treat chronic lymphocytic leukemia (CLL) and indolent non-Hodgkin lymphoma (NHL). It works by damaging the DNA of cancer cells, leading to their death. This medication is administered intravenously under medical supervision.

Bendamustine Hydrochloride is an alkylating agent that forms electrophilic alkyl groups, which covalently bond to DNA. This results in intra- and inter-strand crosslinks between DNA bases, leading to cell death. It is effective against both dividing and quiescent cells, although the exact mechanism is not fully understood.

The dosage of Bendit 100mg is determined by a healthcare professional based on the patient's condition and body surface area. It is typically administered intravenously over 30 to 60 minutes, once every 3 to 4 weeks, depending on the specific treatment protocol.

The safety of Bendit 100mg during pregnancy or breastfeeding has not been established. It is important to consult a healthcare provider before using this medication if you are pregnant, planning to become pregnant, or breastfeeding.

To order Bendit 100mg from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will then provide pricing, availability, shipping details, and the necessary import paperwork.

Bendit 100mg is a unique alkylating agent that combines the properties of both purine analogs and alkylating agents. It is particularly effective in treating chronic lymphocytic leukemia (CLL) and indolent non-Hodgkin lymphoma (NHL). Compared to other cancer treatments, it has a distinct mechanism of action and side effect profile.

Bendit 100mg should be stored below 25°C, kept in the original packaging, and protected from moisture and light. It should not be frozen or shaken. Always follow the storage instructions provided by the manufacturer to ensure the medication's efficacy and safety.

Bendit 100mg is administered intravenously by a healthcare professional. The injection is typically given over 30 to 60 minutes, and the dosage schedule is determined by the patient's specific treatment plan. It is important to follow the prescribed schedule and consult a doctor for any adjustments.

The most serious risks associated with Bendit 100mg include severe infections due to low white blood cell counts, severe allergic reactions, and an increased risk of non-melanoma skin cancer. Patients should be monitored regularly and report any unusual symptoms to their healthcare provider immediately.

Bendit 100mg should not be used by individuals who are allergic to bendamustine or any of its components. It should be used with caution in patients with a history of bone marrow suppression, infections, or other serious medical conditions. Always consult a healthcare provider before starting treatment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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