Product image of Lévodopa/Bensérazide Teva (Benserazide Hydrochloride, Levodopa) supplied by GNH India

Lévodopa/Bensérazide Teva

Active Ingredient:
Benserazide Hydrochloride, Levodopa
Origin:
EU

Lévodopa/Bensérazide Teva (Benserazide Hydrochloride, Levodopa)

Levodopa/Benserazide, the active ingredient in Lévodopa/Bensérazide Teva, is an antiparkinson agent presented as an oral tablet for oral use. It treats Parkinson's disease by restoring dopamine activity in the central nervous system of adult patients. The combination of levodopa with benserazide enhances central availability while minimizing peripheral side effects, making it a cornerstone of symptomatic management.

GNH India supplies Lévodopa/Bensérazide Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches for global distribution.

Manufacturer / TM Owner

Teva Santé

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Indications & Clinical Uses

Levodopa/Benserazide is used in the management of Parkinsonian disorders, targeting dopaminergic deficiency.

  • Parkinson's disease: reduces bradykinesia, rigidity and tremor, improving motor function.
  • Drug‑induced Parkinsonian syndrome: alleviates motor deficits caused by dopamine‑blocking antipsychotics.
  • Secondary parkinsonism due to cerebrovascular disease: helps control motor symptoms when dopaminergic loss is present.

How It Works

  • Levodopa is a dopamine precursor that crosses the blood‑brain barrier and is decarboxylated to dopamine within central neurons. Benserazide is a peripheral aromatic L‑amino acid decarboxylase inhibitor that does not cross the barrier, thereby preventing peripheral conversion of levodopa to dopamine, increasing its cerebral availability and reducing peripheral side effects such as nausea.

Side Effects

Levodopa/Benserazide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea: mild to moderate stomach upset, often transient.
  • Vomiting: occasional emesis, especially at treatment initiation.
  • Orthostatic hypotension: dizziness upon standing due to peripheral vasodilation.
  • Dyskinesia: involuntary movements that may develop with chronic therapy.

Serious or Rare Side Effects

  • Neuroleptic malignant‑like syndrome: rare but life‑threatening reaction with high fever and rigidity.
  • Cardiac arrhythmias: uncommon but may occur, requiring monitoring.

Precautions & Warnings

Levodopa/Benserazide requires careful clinical monitoring and patient education.

  • Dose titration: start with a low dose and increase gradually under medical supervision.
  • Psychiatric monitoring: watch for hallucinations, confusion or mood changes.
  • Avoid abrupt discontinuation: sudden stop may precipitate severe withdrawal symptoms.
  • Renal/hepatic impairment: consider dose adjustment or increased monitoring.
  • Concomitant MAO‑B inhibitors: risk of hypertensive crisis; assess benefit‑risk.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Levodopa/Benserazide interacts with several drug classes; some require avoidance while others need close monitoring.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: may precipitate hypertensive crisis.
  • Anticholinergic agents: can mask motor side effects and worsen confusion.
  • CNS depressants (e.g., barbiturates): reduce levodopa efficacy.
  • High‑protein meals: decrease levodopa absorption, reducing therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Selective MAO‑B inhibitors (e.g., selegiline): may enhance dopaminergic activity and increase side‑effect risk.
  • Antipsychotics (e.g., haloperidol): antagonize dopamine receptors, diminishing drug benefit.
  • Iron or calcium supplements: can bind levodopa in the gut and lower its bioavailability.

Frequently Asked Questions

Lévodopa/Bensérazide Teva is prescribed to manage the motor symptoms of Parkinson's disease and other Parkinsonian syndromes. By restoring dopamine activity in the brain, it helps reduce tremor, rigidity, and slowness of movement, improving patients' daily functioning.

Levodopa serves as a precursor that is converted to dopamine inside the brain, replenishing depleted neurotransmitter levels. Benserazide blocks the peripheral enzyme that would otherwise convert levodopa to dopamine outside the central nervous system, thereby increasing the amount that reaches the brain and reducing peripheral side effects.

The exact dose is individualized and set by the prescribing clinician based on disease severity, patient age, and response to therapy. Dosage adjustments are made during treatment to balance symptom control with tolerability, and patients should follow their healthcare provider's instructions.

Safety data for levodopa/benserazide in pregnancy and lactation are limited. The product is classified as having an unknown pregnancy category, and use is generally reserved for situations where the potential benefit outweighs potential risks. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Compared with levodopa alone, the addition of benserazide improves central delivery of levodopa and reduces peripheral adverse effects such as nausea. Relative to dopamine agonists, levodopa/benserazide generally offers stronger symptomatic control but may be associated with motor complications like dyskinesia over long‑term use.

Store the tablets at ambient temperature, preferably below 25 °C, in the original blister pack or container. Protect them from moisture, excessive heat, and direct sunlight. Keep the product out of reach of children and do not use if the packaging is damaged.

The medication is taken orally with a glass of water. It can be taken with or without food, but high‑protein meals may interfere with absorption, so clinicians often advise spacing the dose from protein‑rich foods. Swallow tablets whole; do not crush or chew unless specifically instructed.

Serious adverse events include neuroleptic malignant‑like syndrome, which presents with high fever, muscle rigidity, and autonomic instability, and cardiac arrhythmias. Severe dyskinesia and psychiatric disturbances such as hallucinations may also occur, especially at higher doses or with rapid dose escalation.

Patients with known hypersensitivity to levodopa, benserazide, or any excipients should avoid the product. It is contraindicated in individuals taking non‑selective MAO inhibitors, those with narrow‑angle glaucoma, and patients with severe hepatic impairment. Clinicians must evaluate each case for additional contraindications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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