Humex Citron Sans Sucre, Édulcorée À L’isomalt Et À L’aspartam (Benzydamine Hydrochloride)

Humex Citron Sans Sucre, Édulcorée À L’isomalt Et À L’aspartam is indicated for relief of discomfort in the oral cavity caused by several common conditions. The product provides a local anti‑inflammatory and analgesic effect, helping to reduce pain and inflammation without systemic absorption.

• Sore throat associated with viral or mild bacterial infections.
• Pharyngitis causing irritation and pain in the throat.
• Oral mucositis related to chemotherapy, radiotherapy, or trauma.
• Painful mouth ulcers or aphthous lesions.
• Post‑operative throat discomfort after minor ENT procedures.

• Benzydamine hydrochloride acts locally on the mucosal surfaces of the oropharynx. It inhibits the release of pro‑inflammatory cytokines such as interleukin‑1 and tumor‑necrosis factor‑α, stabilises cell membranes, and reduces the activity of phospholipase A2. These actions limit the synthesis of prostaglandins and leukotrienes, producing analgesic, anti‑inflammatory and mild antiseptic effects confined to the site of application.

Adverse reactions to benzydamine hydrochloride are generally mild and limited to the area of application, but rare serious events have been reported.

Common

• A brief burning or stinging feeling that resolves within minutes after use.
• Slight alteration of taste, often described as metallic or sweet, which disappears after a short period.
• Localized itching or mild irritation of the oral mucosa without ulceration.
• Sensation of dry mouth that typically subsides with continued use.

Serious

• Development of allergic contact dermatitis presenting as redness, swelling, or rash in the mouth.
• Angio‑edema affecting the lips, tongue, or surrounding tissues, potentially compromising airway.
• Rare systemic hypersensitivity such as anaphylactic reaction requiring immediate medical attention.

When using Humex Citron Sans Sucre, it is important to follow safety guidelines to minimize risks and ensure appropriate use.

• Do not use if you have a known hypersensitivity to benzydamine or any excipients.
• Avoid swallowing large amounts; the product is intended for topical use only.
• Keep out of reach of children; accidental ingestion may cause gastrointestinal irritation.
• Discontinue use and seek medical advice if symptoms persist longer than 7 days.
• Use with caution in patients with severe liver or kidney impairment, as metabolism may be altered.
• Pregnant or breastfeeding women should consult a healthcare professional before use due to limited safety data.

Benzydamine hydrochloride may interact with other substances applied to the oral cavity or systemic medications that affect coagulation or immune response.

Avoid

• Concurrent use of other topical oral anesthetics or anti‑inflammatory sprays, which may increase local irritation.
• Alcohol‑based mouthwashes, as they can enhance mucosal absorption and irritation.
• Systemic non‑steroidal anti‑inflammatory drugs (NSAIDs) when combined with high‑dose benzydamine, potentially increasing bleeding risk.

Use with caution

• Anticoagulant therapy (e.g., warfarin) because local inflammation reduction may mask bleeding signs.
• Immunosuppressive agents, as altered mucosal immunity could affect healing.