Orocalm Goût Citron (Benzydamine Hydrochloride)

• Benzydamine Hydrochloride acts locally on inflammatory conditions of the oral cavity.
• Sore throat: reduces pain and inflammation in the pharyngeal mucosa.
• Oral mucositis: alleviates discomfort associated with chemotherapy‑induced mucosal lesions.
• Mouth ulcer pain: provides local analgesia and anti‑inflammatory effect for aphthous ulcers.

• Benzydamine Hydrochloride exerts its effect by inhibiting prostaglandin synthesis and reducing the release of pro‑inflammatory cytokines in the oral mucosa. It interferes with phospholipase A2 activity, limiting arachidonic acid availability, and modulates the NF‑κB pathway, leading to decreased inflammatory mediator production. Its topical application results in rapid onset of anti‑inflammatory, analgesic and mild anesthetic effects localized to the site of contact.

Benzydamine Hydrochloride is generally well tolerated, but local or systemic adverse reactions may occur.

Common Side Effects

• Taste alteration: transient metallic or bitter taste.
• Mild oral irritation: burning or tingling sensation.
• Nausea: occasional feeling of queasiness.
• Dry mouth: reduced salivation.

Serious or Rare Side Effects

• Allergic reactions: rash, pruritus, angioedema or anaphylaxis.
• Severe mucosal ulceration: unexpected worsening of oral lesions.
• Hepatic dysfunction: abnormal liver enzymes (rare).
• Blood dyscrasias: neutropenia or thrombocytopenia (very rare).

• When using Orocalm Goût Citron, consider the following precautions to ensure safe and effective use.
• Pregnancy: safety has not been established; avoid use unless clearly needed.
• Breastfeeding: unknown risk; consult healthcare professional before use.
• Age restrictions: not recommended for children under 2 years without medical advice.
• Concurrent oral lesions: assess for possible irritation before application.
• Allergy history: avoid if known hypersensitivity to benzydamine or related compounds.
• Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Benzydamine Hydrochloride may interact with certain medicines; awareness of these interactions helps prevent reduced efficacy or increased toxicity.

Major Interactions (Avoid)

• Anticoagulants: benzydamine may enhance bleeding risk when combined with warfarin or direct oral anticoagulants.
• Systemic NSAIDs: concurrent use can increase gastrointestinal irritation.

Moderate Interactions (Monitor Closely)

• Antihistamines: may diminish local anesthetic effect.
• Corticosteroid mouthwashes: potential additive anti‑inflammatory effect, monitor for over‑suppression.
• Alcohol‑containing oral products: may increase mucosal irritation.