Orocalmin Cu Aromă De Portocală Şi Miere (Benzydamine Hydrochloride)

Benzydamine hydrochloride is used for inflammatory conditions of the oral cavity and pharynx, providing symptomatic relief.

• Sore throat: Reduces pain and inflammation in acute pharyngitis.
• Oral mucositis: Alleviates discomfort in patients undergoing chemotherapy or radiotherapy.
• Gingivitis: Decreases inflammation and soreness associated with gum disease.
• Post‑operative oral care: Helps control pain after dental surgeries.
• Minor oral ulcers: Provides soothing relief from ulcer‑related irritation.

• Benzydamine hydrochloride acts locally by inhibiting the synthesis of pro‑inflammatory mediators such as prostaglandins and cytokines, and by stabilising cell membranes. It also exhibits mild local anaesthetic properties through sodium‑channel blockade, which together reduce pain and swelling in the oral mucosa.

Benzydamine hydrochloride is generally well tolerated, but adverse reactions can occur.

Common Side Effects

• Taste alteration: Unpleasant or metallic taste in the mouth.
• Mild burning sensation: Transient feeling of warmth at the site of application.
• Nausea: Slight feeling of queasiness after use.
• Dry mouth: Reduced salivation during treatment.

Serious or Rare Side Effects

• Allergic reaction: Hives, swelling, or difficulty breathing.
• Severe mucosal irritation: Persistent ulceration or intense burning.
• Angioedema: Rapid swelling of lips, tongue, or face.
• Anaphylaxis: Life‑threatening systemic allergic response.

Benzydamine hydrochloride should be used with awareness of specific safety considerations.

• Contraindication: Do not use in patients with known hypersensitivity to benzydamine or related compounds.
• Pregnancy: Limited data; avoid unless clearly needed and prescribed by a physician.
• Breastfeeding: Use with caution; small amounts may pass into milk.
• Interactions: Avoid concurrent use of other topical oral anesthetics without professional advice.
• Storage: Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Benzydamine hydrochloride may interact with other medications applied to the oral cavity or systemic drugs that affect bleeding.

Major Interactions (Avoid)

• Anticoagulants: Increased risk of oral bleeding when combined with warfarin or direct oral anticoagulants.

Moderate Interactions (Monitor Closely)

• Other topical anesthetics: Additive local‑anaesthetic effect may increase numbness.
• Corticosteroid mouthwashes: May alter mucosal absorption and efficacy.
• Alcohol‑based oral rinses: Can enhance irritation.
• Chemotherapeutic agents: May affect mucosal healing dynamics.