Gluconato De Cálcio Labesfal (Calcium Gluconate Monohydrate)

Gluconato De Cálcio Labesfal is indicated for clinical situations where calcium levels need to be restored quickly.

• Treatment of acute hypocalcemia confirmed by laboratory testing.
• Management of calcium deficiency associated with parathyroid disorders.
• Electrolyte replacement during major surgery or massive transfusion.
• Support of cardiac function when calcium‑dependent contractility is compromised.
• Adjunct therapy in patients receiving calcium‑channel blocker overdose (under specialist guidance).
• Correction of calcium loss in patients with extensive burns or severe trauma.
• Prevention of tetany in postoperative patients with low serum calcium.

Side effects reported with intravenous calcium gluconate vary in frequency and severity.

Common

• Transient redness or irritation at the injection site.
• Mild nausea or a feeling of warmth during infusion.
• Temporary low blood pressure (hypotension) that resolves spontaneously.
• Slight increase in heart rate (tachycardia) without other symptoms.

Serious

• Severe hypercalcemia leading to confusion, muscle weakness, or cardiac arrhythmias.
• Allergic reactions such as rash, itching, or swelling of the face and throat.
• Rapid drop in blood pressure (shock) requiring immediate medical intervention.
• Calcium precipitation in the bloodstream causing vascular occlusion (rare).

Before administering Gluconato De Cálcio Labesfal, clinicians should evaluate several precautionary factors to ensure safe use.

• Verify serum calcium levels and correct any underlying electrolyte imbalances.
• Assess renal function, as impaired kidneys may reduce calcium clearance.
• Avoid rapid infusion rates to minimize the risk of cardiovascular irritation.
• Review patient history for hypersensitivity to calcium salts or related compounds.
• Use caution in patients with cardiac disease, especially those prone to arrhythmias.
• Monitor for signs of hypercalcemia during and after infusion.
• Ensure compatible IV solutions are used to prevent calcium precipitation.

Calcium gluconate can interact with certain medications or solutions, influencing efficacy or safety.

Avoid

• Do not mix the injectable solution with phosphate‑containing intravenous fluids, because calcium phosphate precipitation can occur and obstruct catheters.
• Avoid simultaneous administration of bisphosphonates, since calcium may bind to the drug and markedly reduce its oral absorption.
• Refrain from giving calcium gluconate together with loop diuretics without close monitoring of serum calcium and renal function.

Use with caution

• Use with caution when patients are receiving digitalis glycosides; increased extracellular calcium can potentiate the drug’s cardiac effects and precipitate arrhythmias.
• Monitor serum electrolytes closely if calcium gluconate is combined with thiazide diuretics, which can decrease urinary calcium excretion and raise calcium levels.
• Adjust infusion rates and observe neuromuscular status when calcium gluconate is co‑administered with magnesium sulfate, as both ions influence muscle and nerve function.