Product image of Kéforal (Cefalexin Monohydrate) supplied by GNH India

Kéforal

Active Ingredient:
Cefalexin Monohydrate
Origin:
EU

Kéforal (Cefalexin Monohydrate)

Cefalexin Monohydrate, the active ingredient in Kéforal, is a first‑generation cephalosporin presented as an oral tablet for systemic use. It treats a range of bacterial infections in adults and children, including skin, respiratory and urinary tract infections.

GNH India supplies Kéforal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoires Sciencex

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Indications & Clinical Uses

Cefalexin Monohydrate is a broad‑spectrum cephalosporin antibiotic used to treat infections caused by susceptible bacteria.

  • Skin and soft‑tissue infections: resolves cellulitis, impetigo and wound infections.
  • Respiratory tract infections: treats acute bronchitis, sinusitis and community‑acquired pneumonia.
  • Urinary tract infections: eradicates uncomplicated cystitis and pyelonephritis.
  • Bone and joint infections: aids in osteomyelitis and septic arthritis management.
  • Otitis media: clears middle‑ear bacterial infection in children and adults.

How It Works

  • Cefalexin Monohydrate binds to penicillin‑binding proteins on the bacterial cell wall, inhibiting the final transpeptidation step of peptidoglycan synthesis. This disruption weakens the cell wall, leading to osmotic instability and bacterial lysis, particularly against Gram‑positive organisms and some Gram‑negative strains.

Side Effects

Adverse reactions may occur with any antibiotic therapy.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: often self‑limited, may be watery.
  • Abdominal pain: cramping or discomfort.
  • Rash: erythematous skin eruption.
  • Headache: transient tension‑type pain.
  • Vaginal candidiasis: overgrowth due to altered flora.

Serious or Rare Side Effects

  • Clostridioides difficile‑associated colitis: severe watery diarrhea.
  • Anaphylaxis: rapid onset of hives, airway swelling, hypotension.
  • Stevens‑Johnson syndrome: painful skin blistering and mucosal involvement.
  • Hematologic abnormalities: neutropenia, eosinophilia, thrombocytopenia.
  • Hepatic dysfunction: elevated transaminases or jaundice.
  • Renal impairment: interstitial nephritis or worsening kidney function.

Precautions & Warnings

Before prescribing Cefalexin Monohydrate, clinicians should consider patient‑specific factors and safety measures.

  • Allergy assessment: verify no known hypersensitivity to penicillins or cephalosporins.
  • Renal function: adjust dose in patients with impaired clearance.
  • Hepatic impairment: use with caution in liver disease.
  • Elderly patients: monitor for increased adverse effects due to altered pharmacokinetics.
  • Concomitant antibiotics: avoid unnecessary combination therapy to reduce resistance risk.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Cefalexin Monohydrate can alter the activity of several co‑administered medicines.

Major Interactions (Avoid)

  • Probenecid: reduces renal excretion, increasing cefalexin plasma levels.
  • Warfarin: may enhance anticoagulant effect, raising INR.
  • Oral contraceptives: possible reduction in contraceptive efficacy.
  • Aminoglycosides: combined nephrotoxicity risk.
  • Live bacterial vaccines: decreased vaccine effectiveness.

Moderate Interactions (Monitor Closely)

  • Antacids containing aluminum or magnesium: decrease cefalexin absorption.
  • Diuretics (e.g., furosemide): may affect renal clearance.
  • Metformin: monitor for altered renal elimination.
  • Allopurinol: rare reports of rash when combined.

Frequently Asked Questions

Kéforal contains cefalexin monohydrate, a first‑generation cephalosporin that is indicated for bacterial skin and soft‑tissue infections, respiratory tract infections such as sinusitis and bronchitis, urinary tract infections, bone and joint infections, and acute otitis media. It is prescribed when the causative organisms are known or suspected to be susceptible to cefalexin.

Cefalexin monohydrate inhibits bacterial cell‑wall synthesis by binding to penicillin‑binding proteins. This blocks the cross‑linking of peptidoglycan strands, weakening the wall and causing osmotic lysis of susceptible bacteria, particularly Gram‑positive cocci and some Gram‑negative rods.

The dosage of Kéforal is individualized by the prescribing clinician based on the infection type, severity, patient age, weight, and renal function. Healthcare professionals determine the appropriate strength, frequency, and duration of therapy according to established clinical guidelines.

Safety data for cefalexin in pregnancy are limited, and the drug should only be used when clearly needed and after risk‑benefit assessment by a healthcare provider. Cefalexin is excreted in breast milk in small amounts; breastfeeding mothers should consult their physician before use.

To request Kéforal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Kéforal (cef alexin) is a first‑generation cephalosporin offering broad activity against many Gram‑positive organisms and some Gram‑negative bacteria. Compared with penicillins, it is more resistant to β‑lactamase degradation, and versus later‑generation cephalosporins, it has a narrower spectrum, which can reduce collateral impact on normal flora.

Kéforal tablets should be stored at room temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the container tightly closed and out of reach of children.

Kéforal is taken orally, usually with or without food as directed by the prescriber. The tablets should be swallowed whole with a full glass of water. If a liquid formulation is supplied, it must be measured with a calibrated device.

Serious adverse reactions include severe allergic responses such as anaphylaxis, Clostridioides difficile‑associated colitis, Stevens‑Johnson syndrome, and blood dyscrasias like neutropenia. Patients should seek immediate medical attention if they develop rash, persistent diarrhea, fever, or signs of an allergic reaction.

Kéforal is contraindicated in individuals with a known hypersensitivity to cefalexin, other cephalosporins, or penicillins. It should also be avoided in patients with a history of severe allergic reactions to β‑lactam antibiotics. Clinicians must assess risk before prescribing to patients with renal impairment or those receiving interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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