Celecoxib Macleods Pharma Uk (Celecoxib)

Celecoxib Macleods Pharma UK is prescribed for several inflammatory and painful musculoskeletal conditions where reduction of pain and swelling is desired.

• Osteoarthritis – relief of joint pain and stiffness.
• Rheumatoid arthritis – management of chronic inflammatory joint disease.
• Ankylosing spondylitis – alleviation of spinal pain and reduced inflammation.
• Acute pain – short‑term treatment of moderate to severe pain, such as postoperative or dental pain.
• Familial adenomatous polyposis – reduction of colorectal polyp burden (off‑label in some regions).

The safety profile of celecoxib includes both frequently reported and less common adverse events.

Common

• Headache
• Diarrhea
• Nausea
• Abdominal pain
• Elevated blood pressure

Serious

• Cardiovascular thrombotic events (e.g., heart attack, stroke)
• Gastrointestinal ulceration or bleeding
• Severe skin reactions (e.g., Stevens‑Johnson syndrome)
• Liver enzyme elevations indicating hepatic injury

Clinicians should evaluate patient history and risk factors before initiating celecoxib therapy.

• Known hypersensitivity to celecoxib or other NSAIDs.
• History of cardiovascular disease, including hypertension or heart failure.
• Prior gastrointestinal ulceration, bleeding, or perforation.
• Severe hepatic or renal impairment.
• Pregnancy, especially the third trimester, unless benefits outweigh risks.
• Concomitant use of anticoagulants or antiplatelet agents.

Celecoxib may interact with several medicines, affecting efficacy or safety.

Avoid

• Anticoagulants (e.g., warfarin) – increased bleeding risk.
• Other NSAIDs or COX‑2 inhibitors – additive gastrointestinal toxicity.
• Certain antihypertensives (e.g., ACE inhibitors, diuretics) – reduced blood‑pressure control.
• Lithium – increased serum lithium levels.
• Methotrexate – higher risk of toxicity.

Use with caution

• Selective serotonin reuptake inhibitors (SSRIs) – potential for bleeding.
• Corticosteroids – heightened gastrointestinal risk.
• Cyclosporine – possible renal function impact.