CERDELGA - Eliglustat

Storage/Handling:

Store at room temperature away from light and moisture.

Uses of CERDELGA - Eliglustat:

Used in the treatment of type 1 Gaucher disease.

Product Introduction:

Cerdelga is designed to diminish the production of a specific protein in the body, particularly in individuals with type 1 Gaucher disease.

Type 1 Gaucher disease is an inherited disorder characterized by the absence of an essential enzyme responsible for breaking down certain fatty substances (lipids). The accumulation of these lipids can lead to various symptoms, such as easy bruising or bleeding, weakness, anemia, bone or joint pain, an enlarged liver or spleen, or bones that are prone to fractures.

Primarily used to address mild to moderate cases of type 1 Gaucher disease in adults, Cerdelga comes into play when a specific liver enzyme (2D6) metabolizes drugs at a particular rate in the body.

While Cerdelga may enhance the condition of the liver, spleen, bones, and blood cells in individuals with Type I Gaucher disease, it's crucial to note that eliglustat does not provide a cure for this condition.

Administer this medication orally, following your doctor's instructions, either with or without food, typically once or twice daily. The manufacturer recommends swallowing the capsules whole, preferably with water, and advises against opening, crushing, or dissolving them before ingestion.

During the course of this medication, it is advisable to refrain from consuming grapefruit or grapefruit juice unless your doctor or pharmacist deems it safe. Grapefruit has the potential to heighten the risk of side effects associated with this medicine. For additional details, consult your doctor or pharmacist.

Side Effects of CERDELGA - Eliglustat:

As your body adjusts to the medication, you may notice an improvement in the following side effects over time. Nevertheless, should these symptoms persist or become more severe, it is crucial to promptly communicate with your doctor or healthcare provider.

Common Cerdelga side effects may include -
Diarrhea
Nausea
Stomach pain
Headache
Tiredness
Back pain
Pain in your arms or legs

Serious Cerdelga 84mg side effects -
Fast/irregular heartbeat
Severe dizziness
Fainting
Dizziness

Other Cerdelga 84mg side effects are -

Cough
Indigestion or acid reflux
Constipation
Pounding heart (palpitations)
Rash

Drug Interactions:

Cerdelga has the potential to lead to a severe heart issue. Your likelihood of encountering this risk may increase if you are concurrently taking specific medications for infections, asthma, heart conditions, high blood pressure, depression, mental health disorders, cancer, malaria, or HIV.

There is a possibility of interactions between eliglustat and numerous other drugs, and certain medications should not be used simultaneously. Inform your doctor about all the medications you are currently taking and any new medications you begin or discontinue. This includes both prescription and over-the-counter medications, as well as vitamins and herbal products. It is crucial to provide a comprehensive overview of your medication regimen to ensure your safety and well-being.

How CERDELGA - Eliglustat Works:

Individuals diagnosed with Gaucher disease type 1 (GD1) experience elevated levels of a fatty substance known as glucosylceramide (GL-1). This accumulation of GL-1 in specific organs, including the spleen, liver, and bones, can give rise to severe symptoms and complications associated with GD1.

Cerdelga (eliglustat) serves as a glucosylceramide synthase inhibitor, actively impeding the body's production of GL-1. By doing so, it effectively reduces the quantity of GL-1 present in the body. This reduction in GL-1 levels contributes to minimizing the buildup of this fatty substance in organs such as the spleen, liver, and other critical areas, thereby addressing the symptoms and complications associated with Gaucher disease type 1.

Safety Instructions For CERDELGA - Eliglustat:

ALCOHOL (Caution) Refrain from consuming excessive alcoholic beverages while using Cerdelga, as it may enhance feelings of dizziness. It is advisable to limit alcohol intake during this medication. PREGNANCY (Consult your doctor) If needed during pregnancy, use this medication only under clear necessity. Discuss potential risks and benefits thoroughly with your doctor before deciding to proceed. BREAST FEEDING Unsafe The passage of this medication into breast milk is uncertain, and due to potential risks to the infant, breastfeeding is not recommended during its use. Consult your doctor for guidance before breastfeeding. Driving (Caution) Avoid driving, operating machinery, or engaging in activities requiring alertness until you can do so safely. LIVER Consult Your Doctor Individuals with liver conditions should inform their doctor or healthcare provider before taking this medication. This ensures appropriate monitoring and potential adjustments to the treatment plan if required. KIDNEY Consult Your Doctor If you have kidney problems, it is crucial to inform your doctor or healthcare provider before using this medication, as certain health conditions may exacerbate or increase the risk of side effects. Children (Not Approved) Cerdelga is not intended for use by individuals under the age of 18 and is not approved for pediatric use.

Habit Forming

No

Remember:

1. Refrain from consuming grapefruit or grapefruit juice while using Cerdelga (eliglustat). The interaction with grapefruit can enhance the absorption of the medication in your body, thereby increasing the risk of potential side effects.
2. Ingest Cerdelga (eliglustat) capsules whole, ideally with water. Avoid opening, crushing, or dissolving the capsules, as this could impact the efficacy of the medication.
3. Seek approval from your doctor before initiating, discontinuing, or adjusting the dosage of any medications. Do not share Cerdelga with others.
4. Inform your doctor or pharmacist of any allergies to eliglustat before commencing the medication.
5. Consumption of alcohol or marijuana (cannabis) may heighten dizziness.
6. Prior to using this medication, disclose your medical history to your doctor or pharmacist, particularly if you have a history of kidney disease or liver problems.
7. Be aware that alcohol or marijuana (cannabis) intake may increase dizziness.

FAQs:

1. What if you overdosed on cerdelga eliglustat?

In the event of an overdose on Cerdelga (eliglustat), should serious symptoms such as fainting or difficulty breathing occur, it is recommended to promptly contact your doctor.

2. How should I take Cerdelga?

To ensure proper usage of Cerdelga, follow your doctor's prescribed instructions precisely. Adhere to all guidelines on your prescription label and carefully review all medication guides or instruction sheets. Your doctor may adjust your dosage periodically.

3. What if I missed a dose of eliglustat 84mg?

If you happen to miss a dose of eliglustat 84mg, take it as soon as you remember. If the next dose is approaching, skip the missed one and resume your regular dosing schedule. Avoid doubling the dose to compensate.

4. How to dispose of Cerdelga 84mg?

When disposing of Cerdelga 84mg, refrain from flushing medications down the toilet or pouring them into a drain unless specifically instructed to do so. Properly discard the product when it expires or is no longer required. Consult your pharmacist or local waste disposal company for guidance.

5. Are there any tests required to do before consuming cerdelga eliglustat?

Prior to consuming cerdelga eliglustat, certain lab and/or medical tests, such as a complete blood count, liver/spleen measurements, and a specific liver enzyme test (CYP2D6 genotype), should be conducted. Ensure you undergo these tests before initiating the medication and throughout its course. Keep all medical and lab appointments.

6. Are there any allergies related to cerdelga eliglustat?

While a severe allergic reaction to cerdelga eliglustat is rare, it is crucial to seek immediate medical assistance if any symptoms of a serious allergic reaction emerge. These symptoms may include rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, or difficulty breathing.