Product image of Citoneurin (Thiamine Hydrochloride, Cyanocobalamin, Pyridoxine Hydrochloride) supplied by GNH India

Citoneurin

Active Ingredient:
Thiamine Hydrochloride, Cyanocobalamin, Pyridoxine Hydrochloride
Origin:
EU

Citoneurin (Thiamine Hydrochloride, Cyanocobalamin, Pyridoxine Hydrochloride)

Citoneurin is a vitamin supplement that combines thiamine hydrochloride, cyanocobalamin, and pyridoxine hydrochloride. It is formulated for intramuscular injection and is marketed in the European Union. The product provides essential B‑vitamins (B1, B6, B12) that serve as co‑enzymes in carbohydrate and amino‑acid metabolism and support red‑blood‑cell formation. It is intended for use to correct or prevent deficiencies of the listed B‑vitamins.

Manufacturer / TM Owner

P&g Health Germany Gmbh

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Indications & Clinical Uses

Citoneurin is indicated for several nutritional and clinical situations where B‑vitamin levels are insufficient.

  • Treatment of thiamine (vitamin B1) deficiency.
  • Treatment of pyridoxine (vitamin B6) deficiency.
  • Treatment of cyanocobalamin (vitamin B12) deficiency.
  • Support of general nutritional status in individuals with increased metabolic demand.
  • Adjunct therapy in conditions associated with anemia or neuropathy related to B‑vitamin deficits.

Side Effects

Side‑effect profiles for intramuscular B‑vitamin complexes are generally mild, but reactions can vary among individuals.

Common

  • Mild pain or irritation at the injection site.
  • Transient flushing or warmth.
  • Low‑grade fever.
  • Headache.

Serious

  • Severe allergic reaction (anaphylaxis) with difficulty breathing.
  • Rapid heart rate or palpitations.
  • Persistent hypotension.

Precautions & Warnings

When considering Citoneurin, healthcare providers should evaluate patient history and specific clinical factors.

  • Avoid use in individuals with known hypersensitivity to any B‑vitamin component.
  • Assess renal or hepatic impairment before administration, as metabolism may be altered.
  • Use caution in pregnant or breastfeeding women; benefits should outweigh potential risks.
  • Monitor patients with a history of cardiovascular disease for possible tachycardia.
  • Do not exceed recommended dosing intervals without medical guidance.
  • Consider baseline vitamin B12 levels to prevent masking of underlying deficiencies.

Avoid Interactions

Citoneurin may interact with certain medications; awareness of these interactions helps prevent adverse outcomes.

Avoid

  • Concurrent use of high‑dose vitamin B6 with levodopa, which may reduce levodopa efficacy.
  • Simultaneous administration with nitrous oxide anesthesia, which can inactivate vitamin B12.

Use with caution

  • Metformin therapy, which may lower vitamin B12 absorption; monitor levels.
  • Anticonvulsants such as phenytoin or carbamazepine, which can affect vitamin B6 status.
  • Oral contraceptives, which may alter vitamin B6 metabolism.

Frequently Asked Questions

Citoneurin contains thiamine hydrochloride (vitamin B1), cyanocobalamin (vitamin B12), and pyridoxine hydrochloride (vitamin B6).

Citoneurin is supplied for intramuscular injection, typically performed by a healthcare professional.

It is used to treat deficiencies of vitamin B1, vitamin B6, and vitamin B12, as well as to provide general nutritional support.

Use during pregnancy should be considered only after consulting a healthcare provider, weighing potential benefits against any risks.

Common reactions include mild pain or irritation at the injection site, transient flushing, low‑grade fever, and headache.

Signs of a severe allergic reaction such as difficulty breathing, rapid heartbeat, or a sudden drop in blood pressure should be treated as an emergency.

Yes, because metformin can reduce vitamin B12 absorption, periodic monitoring is advisable.

High‑dose vitamin B6 may interfere with levodopa effectiveness, so concurrent use should be avoided.

Healthcare providers should assess organ function before administering Citoneurin, as metabolism and excretion may be affected.

The regulatory status varies by region; in many markets it is available without a prescription, but medical guidance is recommended.

Dosing intervals should follow a healthcare professional’s recommendation; exceeding prescribed frequency is not advised.

Stop the injection immediately and seek emergency medical care, especially if symptoms include breathing difficulty or swelling.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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