Product image of Citrafleet (Sodium Picosulfate, Magnesium Oxide, Light, Citric Acid) supplied by GNH India

Citrafleet

Active Ingredient:
Sodium Picosulfate, Magnesium Oxide, Light, Citric Acid
Origin:
EU

Citrafleet (Sodium Picosulfate, Magnesium Oxide, Light, Citric Acid)

Citrafleet is an oral bowel‑cleansing preparation that combines sodium picosulfate, magnesium oxide and citric acid. The product is supplied in a liquid formulation intended for use in the European Union market. It works as a stimulant laxative together with an osmotic component to promote evacuation of the colon before diagnostic procedures. Citrafleet does not contain a specified strength in the publicly available data, currently listed.

Manufacturer / TM Owner

Casen Recordati, S.L.

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Indications & Clinical Uses

Citrafleet is indicated for bowel preparation in adults who require a clean colon for diagnostic or therapeutic procedures.

  • Colonoscopy preparation
  • Barium enema or other radiologic colon imaging
  • Pre‑operative bowel cleansing before colorectal surgery
  • Situations where rapid and thorough colonic evacuation is desired
  • Use in clinical trials requiring standardized bowel cleansing

Side Effects

The most frequently reported adverse events with Citrafleet are related to its laxative action and electrolyte changes.

Common

  • Abdominal cramping or discomfort
  • Diarrhea or loose stools
  • Nausea
  • Thirst or mild dehydration
  • Bloating
  • Transient electrolyte imbalance (e.g., mild hypokalemia)

Serious

  • Severe dehydration
  • Electrolyte disturbances requiring medical attention (e.g., significant hyponatremia)
  • Persistent vomiting
  • Acute renal impairment
  • Allergic reactions such as rash or angioedema

Precautions & Warnings

Before using Citrafleet, healthcare providers should evaluate patient-specific factors and advise on appropriate preparation to minimize risks.

  • Assess renal function and electrolyte status
  • Avoid use in patients with known bowel obstruction or perforation
  • Use with caution in individuals with inflammatory bowel disease
  • Review medication history for drugs that affect fluid balance
  • Ensure adequate fluid intake during the regimen
  • Consider alternative preparations in pregnancy or lactation when safety is uncertain
  • Provide clear instructions on timing and diet

Avoid Interactions

Citrafleet may interact with other medicines that influence fluid, electrolyte balance or gastrointestinal motility.

Avoid

  • Concomitant use of other potent laxatives or stool softeners
  • High‑dose anticholinergic agents that reduce bowel motility
  • Loop or thiazide diuretics that may exacerbate electrolyte loss

Use with caution

  • ACE inhibitors or ARBs due to risk of hyperkalemia
  • NSAIDs that can affect renal function
  • Oral potassium supplements
  • Certain antibiotics (e.g., quinolones) whose absorption may be reduced

Frequently Asked Questions

Citrafleet combines sodium picosulfate, which stimulates colonic peristalsis, with magnesium oxide that draws water into the intestinal lumen, while citric acid acidifies the solution to enhance magnesium citrate formation, together producing a rapid bowel cleanse.

The product is typically mixed with a specified volume of water and consumed in divided doses according to the prescribing information, followed by additional clear fluids to maintain hydration. Exact timing should be confirmed with the healthcare provider.

Renal function should be evaluated before use because magnesium oxide can affect electrolyte balance. Patients with severe renal impairment may require an alternative bowel‑cleansing regimen.

Common side effects include abdominal cramping, diarrhea, nausea, thirst, bloating, and mild, transient changes in electrolyte levels such as low potassium.

Citrafleet should be avoided in individuals with known or suspected bowel obstruction, perforation, or severe inflammatory bowel disease, and in patients with hypersensitivity to any of its components.

Safety in pregnancy has not been established. Healthcare providers usually consider alternative bowel‑cleansing agents for pregnant patients unless the benefits outweigh potential risks.

Patients are generally advised to drink plenty of clear fluids (often at least 2‑3 L) during the preparation period to reduce the risk of dehydration and electrolyte disturbances.

Concurrent use of other potent laxatives or stool softeners is generally avoided to prevent excessive fluid loss and severe electrolyte imbalance.

Seek medical attention promptly. Severe dehydration may require intravenous fluid replacement and monitoring of electrolyte levels.

Citrafleet can affect potassium levels; therefore, caution is advised when used with ACE inhibitors, ARBs, or potassium‑sparing diuretics, as the combination may increase the risk of hyper‑ or hypokalemia.

A repeat dose should only be administered under medical supervision. Unsupervised additional dosing can increase the risk of adverse events.

The cleansing effect typically occurs within 4‑6 hours after the final dose, providing a clear colon suitable for endoscopic or radiologic evaluation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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