Cladribine (Cladrim)

Trade Name : Cladrim

Fresenius Kabi Oncology Ltd.

Injection

Strength 10mg/10 ml
In Stock

Storage/Handling:

Store at a temperature between 2°C to 8°C in a cool and dry place away from sunlight.


Uses of Cladribine (Cladrim):

Used in the treatment of Hairy Cell Leukaemia.


Product Introduction:

Cladrim 10 mg Injection is classified under purine analogues, a category of anticancer medications utilized in treating hairy cell leukaemia. Leukaemia, or blood cancer, is characterized by the abnormal proliferation of immature white blood cells within the bone marrow, leading to a compromised immune system.

The active ingredient in Cladrim 10 mg Injection is Cladribine, falling within the purine antimetabolites class. Its mechanism of action involves impeding DNA synthesis in cancer cells by disrupting the functions of ribonucleotide reductase and DNA polymerase enzymes, responsible for DNA elongation, synthesis, and repair. Should you exhibit an allergy to Cladrim 10 mg Injection, it is crucial to notify your doctor and abstain from its administration. Complete disclosure of your medical history and ongoing medications is imperative before commencing treatment with Cladrim 10 mg Injection.

Inform your doctor if you have pre-existing heart conditions, liver or kidney issues, or if you are taking medications for infections. Due to potential interactions, it is essential to communicate all concurrent medications. The usage of Cladrim 10 mg Injection is discouraged during pregnancy and breastfeeding, necessitating the adoption of effective contraception by both genders throughout the treatment to prevent pregnancy.

While most side effects associated with Cladrim 10 mg Injection are generally self-resolving and do not demand immediate medical attention, it is crucial to be under the administration of a qualified healthcare professional. Self-administration of Cladrim 10 mg Injection is strongly discouraged.


Pack Size: 10ml vial

Pack Size refers to the Quantity of Packs available in 1 order

Pack Insert: Available

Marketing Authorization Holder: Fresenius Kabi

Manufacturing License: MB/94/6

Temperature: 2-8°C

Hazard: No

Cytotoxic: Yes

Each mil contains Cladribine 1mg

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Delivery Process

Submit a Request

You can fill in a request for your medicine through the form provided. You can access the form by clicking on the ‘Get Price’ button.

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Once we review your request, we’ll send you an estimated price for the medicine within 2-5 days.

Confirmation and Payment

You can fill in a request for your medicine through the form provided. You can access the form by clicking on the ‘Get Price’ button.

Submit a Request

You can fill in a request for your medicine through the form provided. You can access the form by clicking on the ‘Get Price’ button.

Side Effects of Cladribine (Cladrim):

Many potential side effects typically resolve on their own as your body adapts to the medication, and most do not necessitate medical intervention. If these effects persist or cause concern, it is advisable to seek guidance from your healthcare provider.
Nausea
Abdominal pain
Constipation
Weakness
Injection site reactions
Pain at the site of injection
Headache
Dizziness
Insomnia
Anxiety
Muscle pain
Rash


Drug Interactions:

Drug & Drug Interactions: It is important to communicate with your healthcare provider about any vaccinations, over-the-counter medications, vitamins, or herbal supplements you may be currently using.

Drug & Food Interactions: There are no identified interactions between the medication and food.

Drug & Disease Interactions: Prior to initiating Cladrim 10 mg Injection treatment, it is crucial to disclose any existing conditions such as liver or kidney disease, hemolytic anaemia, severe bone marrow suppression, thrombocytopenia, or neutropenia to your doctor.


How Cladribine (Cladrim) Works:

Cladrim 10 mg Injection comprises Cladribine and is employed for managing multiple sclerosis. Its mechanism of action involves the hindrance of DNA synthesis, which encompasses the processes of elongation, synthesis, and repair in cancer cells. This inhibition occurs by disrupting the activities of ribonucleotide reductase and DNA polymerase enzymes. Consequently, the proliferation of aberrant cells is arrested, leading to the demise of cancer cells.


How To Use Cladribine (Cladrim):

The appropriate Cladrim dosage varies based on factors such as the patient's age, gender, and medical background. In addition to the prescribed medical condition, the method of administration significantly influences the accurate dosage determination.

The administration of Cladrim 10 mg Injection is carried out intravenously through injection, typically over a seven-day period through continuous infusion. Elements like the patient's weight, concurrent medications, and existing medical conditions contribute to the determination of the medicine's dose. Therefore, it is imperative to adhere strictly to the doctor's prescription when taking this medication.


Safety Instructions For Cladribine (Cladrim):

Alcohol svgALCOHOL consult your healthcare provider The safety of consuming alcohol in conjunction with Cladrim 10 mg Injection is uncertain. It is advisable to seek guidance from your healthcare provider. Pregnancy svgPREGNANCY consult your healthcare provider The use of Cladrim 10 mg Injection is not recommended during pregnancy due to potential harm to the developing fetus. If you are pregnant or planning to conceive, it is crucial to inform your healthcare provider before undergoing treatment with Cladrim 10 mg Injection. Pregnancy should be avoided while using this medication. BREAST FEEDINGBREAST FEEDING not recommended Cladrim 10 mg Injection is likely unsafe during breastfeeding. Limited human data indicates the possibility of the drug passing into breast milk and posing a risk to the infant. Driving svgDriving exercise caution Cladrim 10 mg Injection may induce side effects that could impair your ability to operate a vehicle. Caution is advised when driving while under the influence of this medication. LIVER svgLIVER inform your healthcare provider If you have a history of liver disease, it is important to inform your healthcare provider before starting Cladrim 10 mg Injection. Your doctor may adjust the dosage or recommend an alternative based on your liver condition. KIDNEY svgKIDNEY inform your healthcare provider Inform your healthcare provider about any pre-existing or historical kidney issues before receiving Cladrim 10 mg Injection. Adjustments to the dosage or a suitable alternative may be considered based on your kidney health. Children  svgCHILDREN consult your healthcare provider The use of Cladrim 10 mg Injection is not recommended for children, as its safety and effectiveness in this population have not been established. It is advisable to consult with your healthcare provider regarding suitable alternatives for pediatric patients.


Habit Forming

No


Remember:

1. It is advisable to undergo regular blood tests when undergoing treatment with Cladrim 10 mg Injection to closely monitor for potential indications of anemia, neutropenia, and thrombocytopenia.
2. Pregnant and breastfeeding women should avoid Cladrim 10 mg Injection due to the associated risk of severe embryo-fetal toxicity, rendering it contraindicated for individuals in these categories.
3. If contemplating vaccination, it is crucial to notify your healthcare provider in advance should you observe any symptoms of infection, such as fever, sore throat, rash, or significant diarrhea.
4. Prior to initiating treatment, inform your doctor if you have a history of kidney or liver disease, hemolytic anemia, or severe bone marrow suppression, as this medication may exacerbate these conditions.
5. Before using Cladrim 10 mg Injection, disclose to your healthcare provider any current use of prescription or non-prescription drugs, as well as herbal and dietary supplements. Mention any allergies to specific foods or substances, a history of kidney issues, and if you are pregnant or breastfeeding.
6. Employ a reliable contraceptive method to prevent pregnancy while undergoing treatment with this medication.


FAQs:

1. What is Cladrim 10 mg Injection used for?

Cladrim 10 mg Injection is primarily used to treat certain types of cancer, such as chronic lymphocytic leukemia (CLL) and hairy cell leukemia.

2. How does Cladrim 10 mg Injection work?

Cladrim 10 mg Injection works by interfering with the growth and spread of cancer cells in the body. It is classified as an antimetabolite.

3. What should I discuss with my healthcare provider before using Cladrim 10 mg Inj?

Before using Cladrim 10 mg Inj, inform your healthcare provider about any existing medical conditions, allergies, or medications you are currently taking. It's crucial to discuss your medical history and any potential risks or side effects.

4. How is Cladrim 10 mg Injection administered?

Cladrim 10 mg Injection is typically administered intravenously (IV) by a healthcare professional in a clinical setting.

5. What are the potential side effects of Cladrim 10 mg Injection?

Common side effects may include nausea, vomiting, fatigue, and changes in blood cell counts. However, it's essential to report any unusual or severe side effects to your healthcare provider.

6. Can Cladrim 10 mg Injection be used during pregnancy or breastfeeding?

Discuss with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as the use of Cladrim 10 mg Injection during these periods may have potential risks.

7. What should I do if I miss a dose of Cladrim 10 mg Injection?

If you miss a dose, contact your healthcare provider for guidance. It's essential not to self-administer or make dosage decisions without consulting a medical professional.

8. How should Cladrim 10 mg Injection be stored?

Follow the storage instructions provided by your healthcare provider or on the medication label. Typically, Cladrim 10 mg Injection is stored in a cool, dry place away from direct sunlight.

GNH India distributes Cladrim Injection to various parts of India.


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Wholesalers Suppliers Exporters Doctors MOH Tender Supplies Hospitals Brand CROs Comparator Supplies Generic Cooperate Sourcing Individual Patients Indian Institutional Buyers

Disclaimer

Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Cladribine (Cladrim) which is also known as Cladrim and Manufactured by Fresenius Kabi Oncology Ltd.. It is available in strength of 10mg/10 ml per ml. Read more

Cladribine (Cladrim) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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