Product image of Oрадро (Clarithromycin) supplied by GNH India

Oрадро

Active Ingredient:
Clarithromycin
Origin:
EU

Oрадро (Clarithromycin)

Clarithromycin, the active ingredient in Oрадро, is a macrolide antibiotic presented as a tablet for oral use. It treats bacterial infections such as community‑acquired pneumonia, skin infections and certain atypical mycobacterial diseases in adults and children when prescribed by a healthcare professional.

GNH India supplies Oрадро as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

World Medicine Europe

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Indications & Clinical Uses

Clarithromycin is a macrolide antibiotic that acts on a range of bacterial respiratory, skin and soft‑tissue infections.

  • Community‑acquired bacterial pneumonia: helps eradicate the causative pathogens and improve clinical recovery.
  • Acute bacterial sinusitis: reduces bacterial load and alleviates sinus inflammation.
  • Skin and soft‑tissue infections (e.g., cellulitis, erythema): assists in eliminating susceptible organisms and promotes healing.

How It Works

  • Clarithromycin binds to the 50S subunit of bacterial ribosomes, blocking the translocation step of protein synthesis. This inhibition prevents bacterial growth and leads to a bacteriostatic effect against susceptible Gram‑positive, Gram‑negative and atypical organisms.

Side Effects

Clarithromycin may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Diarrhea: loose stools, often transient.
  • Abdominal pain: cramping or discomfort.
  • Taste disturbance: altered or metallic taste.
  • Headache: mild headache.
  • Rash: mild skin erythema.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis): difficulty breathing, swelling, hives.
  • Hepatotoxicity: elevated liver enzymes, jaundice.
  • Cardiac arrhythmias (QT prolongation): palpitations, fainting.
  • Clostridioides difficile infection: severe colitis with watery diarrhea.
  • Stevens‑Johnson syndrome: severe skin blistering and mucosal involvement.

Precautions & Warnings

Before prescribing clarithromycin, consider patient‑specific factors and monitor for potential adverse events.

  • Hepatic impairment: dose adjustment may be required; monitor liver function tests.
  • Renal impairment: assess kidney function; adjust dose in severe cases.
  • Concomitant QT‑prolonging drugs: avoid or monitor ECG for arrhythmia risk.
  • Pregnancy and lactation: use only if clearly needed; discuss risks with obstetrician.
  • Drug‑resistant infections: verify susceptibility before long‑term use.
  • Store at ambient temperature: keep below 25°C, retain original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Clarithromycin interacts with several medicines through cytochrome P450 inhibition and additive cardiac effects.

Major Interactions (Avoid)

  • Statins (e.g., simvastatin, lovastatin): risk of rhabdomyolysis.
  • Warfarin: increased anticoagulant effect, heightened bleeding risk.
  • Pimozide: may cause severe QT prolongation.

Moderate Interactions (Monitor Closely)

  • Carbamazepine: reduced clarithromycin levels, possible loss of efficacy.
  • Digoxin: increased serum digoxin concentrations.
  • Oral hypoglycemics (e.g., sulfonylureas): enhanced hypoglycaemic effect.

Frequently Asked Questions

Oрадро contains clarithromycin, a macrolide antibiotic that is prescribed for bacterial infections such as community‑acquired pneumonia, acute bacterial sinusitis and skin or soft‑tissue infections caused by susceptible organisms. The exact indication is determined by the treating physician based on clinical assessment and microbiological data.

Clarithromycin binds to the 50S ribosomal subunit of bacteria, inhibiting the translocation step of protein synthesis. This blocks bacterial growth, producing a bacteriostatic effect against a broad range of Gram‑positive, Gram‑negative and atypical pathogens.

The dosage of Oрадро is individualized by the prescribing clinician according to the infection type, severity, patient age, weight and renal or hepatic function. Healthcare providers follow local prescribing guidelines and adjust the regimen as needed.

Clarithromycin is classified as pregnancy category B in many regions, indicating no proven risk in animal studies but limited human data. It should be used only when clearly needed, and the benefits must outweigh potential risks. Clarithromycin does pass into breast milk in small amounts; nursing mothers should consult their physician before use.

To request Oрадро, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Clarithromycin has a longer half‑life and higher tissue penetration than erythromycin, allowing twice‑daily dosing for many infections. Compared with azithromycin, it offers a broader spectrum against certain atypical organisms but may have a higher potential for drug‑drug interactions due to stronger CYP3A4 inhibition.

Store Oрадро tablets at ambient temperature, preferably below 25 °C. Keep the medication in its original container, protect it from moisture, heat and direct sunlight to maintain potency throughout its shelf life.

Oрадро is supplied as oral tablets that should be swallowed whole with a full glass of water. It can be taken with or without food, but taking it with meals may reduce gastrointestinal upset in some patients.

Serious adverse events include severe allergic reactions (anaphylaxis), hepatotoxicity, QT‑interval prolongation leading to cardiac arrhythmias, and Clostridioides difficile‑associated colitis. Patients should be monitored for signs of these conditions, especially if they have pre‑existing heart disease or liver dysfunction.

Clarithromycin is contraindicated in individuals with a known hypersensitivity to macrolide antibiotics, those taking certain contraindicated drugs such as pimozide or specific statins, and patients with a history of significant QT prolongation unless closely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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