Product image of Climara (Estradiol) 50mcg/24hr PATCH supplied by GNH India

Climara

Active Ingredient:
Estradiol
Form:
PATCH
Brand:
Climara
Origin:
Australia

Climara (Estradiol PATCH) 50mcg/24hr

Estradiol, the active ingredient in Climara, is an estrogen presented as a 50mcg/24hr transdermal patch for skin use. It is used to treat menopausal symptoms due to estrogen deficiency during menopause or after surgical procedures where estrogen production is decreased. GNH India supplies Climara as a licensed, GDP-compliant international pharmaceutical supplier serving pharmacies and clinics worldwide.

Climara is designed to deliver estradiol continuously through the skin, providing a controlled and consistent release of the hormone. This method allows for a lower dose of estrogen compared to oral administration, as it bypasses the stomach and liver.

Strength

50mcg/24hr

Manufacturer / TM Owner

Bayer Australia Ltd

1
Pack/s
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Indications & Clinical Uses

Climara is a hormone replacement therapy used to manage symptoms associated with menopause. It is indicated for the treatment of menopausal symptoms due to estrogen deficiency, including hot flushes, night sweats, sleep disturbances, vaginal dryness, depression, nervousness, irritability, headache, and dizziness. It can also be used to prevent bone mineral density loss during menopause.

  • Menopausal symptoms: Relief of hot flushes, night sweats, sleep disturbances, vaginal dryness, depression, nervousness, irritability, headache, and dizziness.
  • Bone mineral density loss: Prevention of bone weakening and brittleness during menopause.
  • Estrogen deficiency: Treatment of symptoms due to decreased estrogen production.

How It Works

  • Climara works by delivering estradiol, a form of estrogen, through the skin and into the bloodstream. Estradiol binds to estrogen receptors (ERα and ERβ) and modulates the transcription of estrogen-responsive genes, restoring estrogenic activity in target tissues. This helps to alleviate menopausal symptoms and prevent bone loss by replacing the estrogen that the body is no longer producing.

Side Effects

Climara may cause side effects, although not everyone gets them. Common side effects include skin irritation at the application site, breast tenderness, headache, and abdominal cramps. Serious or rare side effects are less common but can be more severe.

Common Side Effects

  • Skin irritation at the application site
  • Breast tenderness
  • Headache
  • Abdominal cramps
  • Nausea
  • Bloating
  • Vaginal bleeding

Serious or Rare Side Effects

  • Blood clots
  • Stroke
  • Heart attack
  • Gallbladder disease
  • Liver problems
  • High blood pressure
  • Increased risk of breast cancer

Precautions & Warnings

Climara should be used with caution and under medical supervision. It is important to discuss your medical history and any current medications with your healthcare provider before starting treatment. Regular follow-ups are recommended to monitor for any adverse effects.

  • Medical history: Inform your healthcare provider about any history of blood clots, heart disease, liver disease, or cancer.
  • Allergies: Do not use Climara if you are allergic to estradiol or any of the ingredients in the patch.
  • Pregnancy: Climara should not be used during pregnancy unless clearly necessary.
  • Breastfeeding: Consult your healthcare provider before using Climara while breastfeeding.
  • Children: Climara is not intended for use in children.
  • Storage: Store at 20°C to 25°C (66°F to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F). Do not store above 86°F (30°C).

Avoid Interactions

Climara may interact with other medications, which can affect its effectiveness or increase the risk of side effects. It is important to inform your healthcare provider about all the medications you are taking before starting Climara.

Major Interactions (Avoid)

  • Oral anticoagulants: May increase the risk of bleeding.
  • Thrombolytic agents: May increase the risk of bleeding.
  • Anticonvulsants: May decrease the effectiveness of Climara.

Moderate Interactions (Monitor Closely)

  • Antidepressants: May increase the risk of side effects.
  • Antipsychotics: May increase the risk of side effects.
  • Diuretics: May increase the risk of side effects.

Frequently Asked Questions

Climara is used to treat menopausal symptoms due to estrogen deficiency, including hot flushes, night sweats, sleep disturbances, vaginal dryness, depression, nervousness, irritability, headache, and dizziness. It can also be used to prevent bone mineral density loss during menopause.

Estradiol, the active ingredient in Climara, binds to estrogen receptors (ERα and ERβ) and modulates the transcription of estrogen-responsive genes. This restores estrogenic activity in target tissues, helping to alleviate menopausal symptoms and prevent bone loss.

The usual dose of Climara is determined by a healthcare provider based on individual needs. It is typically applied once a week, with the patch changed on the same day each week.

Climara should not be used during pregnancy unless clearly necessary. Consult your healthcare provider before using Climara while breastfeeding.

To order Climara from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will reply with pricing, availability, shipping, and the import paperwork.

Climara is a transdermal patch that delivers estradiol continuously through the skin. Compared to oral hormone replacement therapies, it allows for a lower dose of estrogen and bypasses the stomach and liver, potentially reducing the risk of certain side effects.

Climara should be stored at 20°C to 25°C (66°F to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F). Do not store above 86°F (30°C). Apply the patch immediately upon removal from the protective pouch and discard used patches by folding the sticky side together and placing them in a sturdy child-proof container.

Climara is administered by applying the patch to intact skin once a week. The patch should be changed on the same day each week. The patch delivers estradiol continuously through the skin and into the bloodstream.

The most serious risks to watch for with Climara include blood clots, stroke, heart attack, gallbladder disease, liver problems, high blood pressure, and an increased risk of breast cancer. Regular follow-ups with a healthcare provider are recommended to monitor for these risks.

Climara should not be used by individuals who are allergic to estradiol or any of the ingredients in the patch. It should also be avoided by those with a history of blood clots, heart disease, liver disease, or cancer unless clearly necessary and under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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