Product image of Onymykén 100 (Clotrimazole) supplied by GNH India

Onymykén 100

Active Ingredient:
Clotrimazole
Origin:
EU

Onymykén 100 (Clotrimazole)

Clotrimazole, the active ingredient in Onymykén 100, is an imidazole antifungal presented as a topical formulation for topical use. It treats superficial fungal infections such as athlete's foot, jock itch, and cutaneous candidiasis in adults and children.

GNH India supplies Onymykén 100 as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Schuck Gmbh

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Indications & Clinical Uses

Clotrimazole is used topically to treat superficial fungal infections caused by dermatophytes and yeasts.

  • Tinea pedis (athlete's foot): reduces fungal growth and relieves itching, scaling and burning.
  • Tinea cruris (jock itch): clears the infection and alleviates redness and discomfort.
  • Cutaneous candidiasis: eliminates Candida overgrowth and improves skin integrity.

How It Works

  • Clotrimazole inhibits fungal ergosterol synthesis by blocking the enzyme lanosterol 14α-demethylase. This disruption impairs the formation of the fungal cell membrane, leading to increased permeability, loss of cellular contents and ultimately fungal cell death. The action is selective for fungal cells, sparing human cells that use cholesterol instead of ergosterol.

Side Effects

Topical clotrimazole is generally well tolerated, but local reactions can occur.

Common Side Effects

  • Mild skin irritation or burning at the application site.
  • Itching or pruritus.
  • Redness or erythema.
  • Dryness or peeling of the skin.
  • Local rash.
  • Stinging sensation.

Serious or Rare Side Effects

  • Allergic contact dermatitis with swelling or blistering.
  • Severe skin reactions such as Stevens‑Johnson syndrome (very rare).
  • Systemic absorption leading to liver enzyme abnormalities (rare).
  • Extensive swelling or edema of the treated area.
  • Persistent ulceration or necrosis of skin.

Precautions & Warnings

Before using Onymykén 100, consider the following safety measures.

  • Application: Apply a thin layer to clean, dry skin and avoid excessive amounts.
  • Avoid use on broken or inflamed skin unless directed by a clinician.
  • Do not combine with other topical antifungal agents without professional advice.
  • Pregnancy/Breastfeeding: Consult a healthcare professional; use only if benefit outweighs risk.
  • Children: Follow pediatric guidance; dosage and duration should be determined by a prescriber.
  • Store at ambient temperature: Keep the product in its original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Clotrimazole may interact with other medicines or topical agents.

Major Interactions (Avoid)

  • Concurrent use of systemic azole antifungals that could increase systemic exposure.
  • Application over large occlusive dressings that may enhance absorption.

Moderate Interactions (Monitor Closely)

  • Use with topical corticosteroids may increase irritation risk.
  • Co‑application with other irritant creams (e.g., salicylic acid) should be monitored.
  • Combining with alcohol‑based products may cause burning.
  • Use with other antifungal creams may lead to additive effects; monitor for skin reactions.

Frequently Asked Questions

Onymykén 100 is an over‑the‑counter topical antifungal indicated for the treatment of superficial fungal infections such as athlete's foot (tinea pedis), jock itch (tinea cruris) and cutaneous candidiasis. It works by applying a thin layer to the affected skin area, helping to eliminate the causative fungi and relieve associated symptoms.

Clotrimazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for converting lanosterol to ergosterol, a key component of the fungal cell membrane. By inhibiting ergosterol synthesis, the drug disrupts membrane integrity, leading to increased permeability, loss of cellular contents and ultimately fungal cell death.

The prescriber determines the exact amount and frequency of application. Typically, a thin layer is applied to the clean, dry affected area once or twice daily for the period recommended by the healthcare professional. Patients should follow the specific instructions provided on the label or by their clinician.

Safety data for clotrimazole in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their healthcare provider before starting treatment.

To order Onymykén 100, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements) and assist with import documentation.

Onymykén 100 (clotrimazole) belongs to the imidazole class and is effective against a broad range of dermatophytes and yeasts. Compared with allylamine agents such as terbinafine, clotrimazole often requires a longer treatment duration but is widely available OTC and has a well‑established safety profile. Miconazole offers similar coverage, while newer agents may provide faster cure rates for specific infections.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original container, protect it from moisture, direct sunlight and excessive heat. Ensure the cap is tightly closed after each use to maintain product stability.

Clean and dry the affected skin area before use. Apply a thin, even layer of the cream to the lesion and the surrounding skin, gently rubbing it in. Wash your hands after application unless the hands are the treatment site. Follow the frequency and duration advised by your healthcare professional.

While rare, serious adverse reactions can include allergic contact dermatitis, severe skin blistering, extensive swelling, or systemic effects such as liver enzyme abnormalities if significant absorption occurs. Users should discontinue the product and seek medical attention if they experience intense rash, swelling, fever, or signs of systemic toxicity.

Individuals with a known hypersensitivity to clotrimazole or any component of the formulation should avoid using the product. It is also contraindicated on severely damaged, ulcerated or inflamed skin unless directed by a clinician. Children under the age specified on the label should only use it under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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