Product image of Cloxacillin 500mg caps (Cloxacillin ) 500mg Capsule supplied by GNH India

Cloxacillin 500mg caps

Active Ingredient:
Cloxacillin
Form:
Capsule
Brand:
Cloxacillin
Origin:
India

Cloxacillin 500mg caps (Cloxacillin Capsule) 500mg

Cloxacillin, the active ingredient in Cloxacillin 500mg capsules, is a penicillinase-resistant penicillin presented as a 500mg capsule for oral use. It is used to treat infections caused by penicillin-resistant staphylococci, including skin, soft tissue, bone, and joint infections. GNH India supplies Cloxacillin 500mg capsules as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

GNH India is a trusted global supplier of high-quality pharmaceuticals, ensuring that Cloxacillin 500mg capsules meet international standards for safety and efficacy.

Strength

500mg

Pack Size

100s

Storage

Ambient

Manufacturer / TM Owner

Jackson Laboratories Pvt Ltd

1
Pack/s
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Indications & Clinical Uses

Cloxacillin 500mg capsules are used to treat infections caused by penicillin-resistant staphylococci. This antibiotic is effective against a range of bacterial infections, including:

  • Skin and soft tissue infections: Treats infections such as boils, abscesses, and cellulitis.
  • Bone and joint infections: Effective in managing osteomyelitis and septic arthritis.
  • Respiratory tract infections: Used to treat pneumonia, lung abscesses, and other respiratory infections.
  • Staphylococcal infections: Targets infections caused by penicillin-resistant staphylococci.

How It Works

  • Cloxacillin works by inhibiting the synthesis of bacterial cell walls. It binds to penicillin-binding proteins, which disrupts the formation of peptidoglycan, a crucial component of the bacterial cell wall. This action leads to the death of susceptible bacteria, making cloxacillin effective against penicillinase-producing staphylococci.

Side Effects

Cloxacillin 500mg capsules may cause various side effects, ranging from common to serious.

Common Side Effects

  • Nausea and vomiting: May occur during treatment.
  • Diarrhea: Common gastrointestinal side effect.
  • Abdominal discomfort: Mild stomach pain or discomfort.
  • Skin rash: May develop as an allergic reaction.
  • Itching: Pruritus may occur.

Serious or Rare Side Effects

  • Severe allergic reactions: Anaphylaxis, though rare, can be life-threatening.
  • Superinfections: Overgrowth of non-susceptible organisms.
  • Hepatotoxicity: Liver damage, though rare, can occur with prolonged use.
  • Hemolytic anemia: Destruction of red blood cells, leading to anemia.

Precautions & Warnings

Cloxacillin 500mg capsules should be used with caution in certain patient groups. Precautions include:

  • Allergies: Avoid in patients with a history of severe penicillin allergy.
  • Renal impairment: Dosage adjustment may be necessary in patients with kidney problems.
  • Pregnancy: Use only if clearly needed, as adequate studies in pregnant women are lacking.
  • Breastfeeding: Caution is advised, as penicillins cross into breast milk.
  • Drug interactions: Monitor for interactions with other medications.
  • Store below 25°C: Keep in a dry place, protect from light and moisture.

Avoid Interactions

Cloxacillin 500mg capsules may interact with other medications, potentially affecting their efficacy or increasing the risk of side effects.

Major Interactions (Avoid)

  • Probenecid: Can increase cloxacillin levels, leading to toxicity.
  • Methotrexate: May increase the risk of methotrexate toxicity.
  • Allopurinol: Can increase the risk of allergic reactions.

Moderate Interactions (Monitor Closely)

  • Oral anticoagulants: May enhance the anticoagulant effect, requiring monitoring.
  • Aminoglycosides: May have additive nephrotoxic effects.
  • Tetracyclines: May reduce the effectiveness of cloxacillin.

Frequently Asked Questions

Cloxacillin 500mg capsules are used to treat infections caused by penicillin-resistant staphylococci. These include skin and soft tissue infections, bone and joint infections, respiratory tract infections, and other staphylococcal infections. The antibiotic works by inhibiting the synthesis of bacterial cell walls, making it effective against a range of bacterial infections.

Cloxacillin works by inhibiting the synthesis of bacterial cell walls. It binds to penicillin-binding proteins, which disrupts the formation of peptidoglycan, a crucial component of the bacterial cell wall. This action leads to the death of susceptible bacteria, making cloxacillin effective against penicillinase-producing staphylococci.

The usual dose of Cloxacillin 500mg capsules is determined by a healthcare professional based on the type and severity of the infection, as well as the patient's age and overall health. It is important to follow the prescribed dosage and complete the full course of treatment to ensure the infection is fully resolved.

Cloxacillin should be used during pregnancy only if clearly needed, as adequate controlled studies in pregnant women are lacking. Penicillins cross the placenta, and caution is advised. During breastfeeding, cloxacillin should be used with caution, as penicillins can cross into breast milk. Consult a healthcare professional for personalized advice.

To order Cloxacillin 500mg capsules from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will reply with pricing, availability, shipping, and the import paperwork.

Cloxacillin is a penicillinase-resistant penicillin, making it effective against penicillin-resistant staphylococci. Compared to other antibiotics, it is specifically targeted at infections caused by these resistant bacteria. It is important to use the appropriate antibiotic based on the type of infection and the susceptibility of the bacteria involved.

Cloxacillin 500mg capsules should be stored below 25°C in a dry place. Protect the capsules from light and moisture. Keep them out of reach of children and do not use after the expiry date. Proper storage ensures the effectiveness and safety of the medication.

Cloxacillin 500mg capsules are administered orally, typically taken with a full glass of water. The capsules should be swallowed whole and not crushed, chewed, or opened. It is important to take the medication at evenly spaced intervals to maintain effective antibacterial levels in the body.

The most serious risks associated with Cloxacillin include severe allergic reactions, such as anaphylaxis, which can be life-threatening. Other serious risks include superinfections, where non-susceptible organisms overgrow, and hepatotoxicity, which is rare but can occur with prolonged use. Monitor for signs of these serious side effects and seek medical attention if they occur.

Cloxacillin 500mg capsules should not be used by individuals with a history of severe penicillin allergy. Patients with renal impairment may require dosage adjustment. The medication should be used with caution in pregnant and breastfeeding women, as well as in those taking other medications that may interact with cloxacillin. Always consult a healthcare professional before starting any new medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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