Product image of Kodein Stærk "dak" (Codeine Phosphate Hemihydrate) supplied by GNH India

Kodein Stærk "dak"

Active Ingredient:
Codeine Phosphate Hemihydrate
Origin:
EU

Kodein Stærk "dak" (Codeine Phosphate Hemihydrate)

Codeine phosphate, the active ingredient in Kodein Stærk "dak", is an opioid analgesic presented as an oral dosage form for oral use. It is employed to relieve moderate pain and to suppress cough in appropriate patients. It is formulated according to EU pharmacopeial specifications and is available only by prescription.

GNH India supplies Kodein Stærk "dak" as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Orifarm Healthcare A/S

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Indications & Clinical Uses

Kodein Stærk "dak" (codeine phosphate) acts on the central nervous system to provide analgesia and antitussive effects.

  • Moderate pain: reduces pain intensity in patients with acute or chronic moderate pain.
  • Acute pain: provides short‑term relief for postoperative or injury‑related pain.
  • Cough: suppresses the cough reflex in patients with non‑productive cough.

How It Works

  • Codeine phosphate is a pro‑drug that is partially metabolized to morphine by hepatic CYP2D6 enzymes. The resulting morphine binds to μ‑opioid receptors in the brain and spinal cord, inhibiting the transmission of nociceptive signals and decreasing the cough reflex center activity. This μ‑opioid receptor agonism produces analgesic and antitussive effects. The activation also leads to reduced release of neurotransmitters such as substance P and glutamate, further contributing to pain relief.

Side Effects

Codeine phosphate may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea: feeling of stomach upset that may lead to vomiting.
  • Constipation: reduced bowel movements and hard stools.
  • Drowsiness: increased sleepiness or fatigue.
  • Dry mouth: reduced salivation causing a parched sensation.

Serious or Rare Side Effects

  • Respiratory depression: slowed or shallow breathing that can be life‑threatening.
  • Severe allergic reaction (anaphylaxis): rash, swelling, difficulty breathing.
  • Dependence or addiction: compulsive use despite harmful consequences.

Precautions & Warnings

When prescribing or dispensing Kodein Stærk "dak", several safety considerations should be observed.

  • Assess pain level and cough severity: ensure the drug is appropriate for the indicated condition.
  • Avoid concurrent CNS depressants: do not combine with alcohol, benzodiazepines or other opioids without medical supervision.
  • Use caution in respiratory disorders: patients with asthma or COPD may be at increased risk of respiratory depression.
  • Monitor for signs of dependence: watch for cravings, tolerance increase or withdrawal symptoms during prolonged therapy.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Codeine phosphate can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • CNS depressants (e.g., benzodiazepines, barbiturates, alcohol): may cause profound sedation and respiratory depression.
  • MAO inhibitors: can precipitate severe hypertension or serotonin syndrome when combined.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may reduce conversion to morphine and diminish analgesic effect.
  • Antihistamines (e.g., diphenhydramine): can increase drowsiness and anticholinergic burden.
  • Diuretics: may enhance the risk of hypotension when combined with opioid‑induced vasodilation.

Frequently Asked Questions

Kodein Stærk "dak" contains codeine phosphate, an opioid analgesic that is prescribed to manage moderate to acute pain and to suppress a non‑productive cough. It is used in adult patients when a short‑acting opioid is appropriate for pain relief or cough control, and it must be prescribed by a qualified healthcare professional.

Codeine phosphate is a pro‑drug that is partially converted to morphine by the liver enzyme CYP2D6. The resulting morphine binds to μ‑opioid receptors in the central nervous system, reducing the transmission of pain signals and dampening the cough reflex. This receptor activation also decreases the release of neurotransmitters such as substance P, contributing to its analgesic effect.

The exact dose of Kodein Stærk "dak" is determined by the prescribing clinician based on the individual’s pain intensity, cough severity, age, weight, renal and hepatic function, and any concomitant medications. Because dosing varies widely, the prescriber sets the appropriate regimen and provides specific instructions for each patient.

Safety data for codeine phosphate in pregnancy and lactation are limited, and the drug is generally classified as contraindicated or to be used only when the potential benefit outweighs the risk. Codeine can cross the placenta and be excreted in breast milk, potentially causing respiratory depression in the newborn. Consultation with a healthcare professional is essential before use.

To place an order, visit the product page on gnhindia.com and submit an enquiry with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with non‑opioid cough suppressants such as dextromethorphan, codeine provides stronger antitussive activity but carries opioid‑related risks like dependence and respiratory depression. In analgesia, codeine offers moderate pain relief, sitting between mild agents such as paracetamol and stronger opioids like morphine. Choice depends on the severity of symptoms and the patient’s risk profile.

Store Kodein Stærk "dak" at room temperature, below 25 °C, in the original container. Keep the product away from moisture, direct sunlight and sources of heat. Do not store in the bathroom or near a kitchen sink, and keep it out of reach of children.

Kodein Stærk "dak" is administered orally, typically as a tablet that is swallowed whole with water. The prescriber will indicate the exact dosing schedule, which may be taken with or without food depending on the patient’s tolerance. Patients should follow the label instructions and not exceed the prescribed amount.

The most serious risks include respiratory depression, especially in patients with underlying lung disease or when combined with other CNS depressants, severe allergic reactions (anaphylaxis), and the potential for dependence, addiction or withdrawal symptoms with prolonged use. Any signs of shallow breathing, rash, swelling or unusual cravings should prompt immediate medical attention.

Kodein Stærk "dak" should be avoided in individuals with known hypersensitivity to codeine or other opioids, severe respiratory insufficiency, acute or severe asthma, paralytic ileus, and in patients taking MAO inhibitors. It is also contraindicated in children under the age specified by local regulations and in anyone for whom an opioid is medically inappropriate.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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