Product image of Cosimprel (Bisoprolol Fumarate, Perindopril Arginine) supplied by GNH India

Cosimprel

Active Ingredient:
Bisoprolol Fumarate, Perindopril Arginine
Origin:
EU

Cosimprel (Bisoprolol Fumarate, Perindopril Arginine)

Bisoprolol fumarate and perindopril arginine, the active ingredients in Cosimprel, are a beta-blocker and an ACE inhibitor, respectively, presented as a 5 mg/5 mg film-coated tablet for oral use. It is used to treat hypertension, chronic heart failure, and to reduce the risk of cardiovascular events in patients with stable coronary artery disease. GNH India supplies Cosimprel as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

GNH India is a trusted supplier of high-quality pharmaceuticals, ensuring that Cosimprel meets international standards for safety, efficacy, and quality.

Manufacturer / TM Owner

Les Laboratoires Servier (Suresnes)

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Indications & Clinical Uses

Cosimprel is used to manage cardiovascular conditions by acting on the cardiovascular system. It is indicated for the following conditions:

  • Hypertension: Reduces blood pressure in patients with high blood pressure.
  • Chronic heart failure: Improves symptoms and reduces the risk of hospitalisation in patients with chronic heart failure.
  • Post-myocardial infarction management: Reduces the risk of cardiovascular events in patients who have had a heart attack.

How It Works

  • Bisoprolol selectively blocks β1-adrenergic receptors, reducing heart rate and myocardial contractility. Perindopril inhibits angiotensin-converting enzyme (ACE), decreasing the formation of angiotensin II and lowering vascular resistance. Together, these actions help to reduce blood pressure and improve heart function.

Side Effects

Cosimprel may cause side effects, which can be categorised as common or serious/rare.

Common Side Effects

  • Dizziness: May occur due to the blood pressure-lowering effect.
  • Fatigue: Commonly reported, especially at the start of treatment.
  • Headache: May occur as the body adjusts to the medication.
  • Nausea: Can be managed by taking the medication with food.
  • Diarrhoea: May occur in some patients.
  • Cough: Often associated with ACE inhibitors like perindopril.

Serious or Rare Side Effects

  • Hypotension: Severe low blood pressure may occur, especially in sensitive individuals.
  • Bradycardia: Slow heart rate may require dose adjustment or discontinuation.
  • Allergic reactions: Rare but can be serious, including rash, itching, or swelling.
  • Liver dysfunction: Monitor liver function tests in patients with pre-existing liver disease.

Precautions & Warnings

Cosimprel should be used with caution in certain patient groups and conditions. Precautions include:

  • Pregnancy: Avoid use during pregnancy unless clearly necessary, as it may harm the foetus.
  • Breastfeeding: Use with caution and only if the benefits outweigh the risks.
  • Liver disease: Monitor liver function regularly in patients with liver impairment.
  • Kidney disease: Adjust dosage based on renal function.
  • Diabetes: Monitor blood sugar levels regularly, as beta-blockers can mask symptoms of hypoglycaemia.
  • Asthma: Use with caution in patients with asthma or chronic obstructive pulmonary disease (COPD).
  • Store below 25°C: Keep in the original pack, protect from moisture.

Avoid Interactions

Cosimprel may interact with other medications, which can be categorised as major or moderate interactions.

Major Interactions (Avoid)

  • Non-steroidal anti-inflammatory drugs (NSAIDs): May reduce the blood pressure-lowering effect of Cosimprel.
  • Diuretics: May increase the risk of hypotension when taken with Cosimprel.
  • Potassium-sparing diuretics: May increase the risk of hyperkalaemia.
  • Lithium: May increase the risk of lithium toxicity.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: May enhance the blood pressure-lowering effect.
  • Antiarrhythmic drugs: May increase the risk of bradycardia.
  • Insulin and oral hypoglycaemic agents: May require dose adjustment due to the effect on blood sugar levels.

Frequently Asked Questions

Cosimprel is used to treat hypertension, chronic heart failure, and to reduce the risk of cardiovascular events in patients with stable coronary artery disease. It combines the effects of a beta-blocker (bisoprolol) and an ACE inhibitor (perindopril) to manage these conditions effectively.

Bisoprolol selectively blocks β1-adrenergic receptors, reducing heart rate and myocardial contractility. Perindopril inhibits angiotensin-converting enzyme (ACE), decreasing the formation of angiotensin II and lowering vascular resistance. Together, these actions help to reduce blood pressure and improve heart function.

The usual dose of Cosimprel is determined by a healthcare professional based on the patient's condition, response to treatment, and other factors. It is typically taken once daily, and the dose may be adjusted as needed.

Cosimprel should be avoided during pregnancy unless clearly necessary, as it may harm the foetus. It should be used with caution during breastfeeding, and only if the benefits outweigh the risks. Always consult a healthcare professional for personalised advice.

To order Cosimprel from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will then reply with pricing, availability, shipping, and the import paperwork.

Cosimprel combines the effects of a beta-blocker and an ACE inhibitor, making it effective for managing hypertension and chronic heart failure. Compared to other hypertension medications, it offers a dual mechanism of action, which can be beneficial for patients who require both types of treatment.

Cosimprel should be stored below 25°C, kept in the original pack, and protected from moisture. Ensure that the medication is stored out of reach of children and pets. Always follow the storage instructions provided with the medication.

Cosimprel is administered orally, typically once daily. The tablet should be swallowed whole with a glass of water, preferably in the morning. It can be taken with or without food, but taking it with food may help to reduce the risk of gastrointestinal side effects.

The most serious risks to watch for with Cosimprel include severe low blood pressure (hypotension), slow heart rate (bradycardia), and allergic reactions. Patients should seek immediate medical attention if they experience symptoms such as dizziness, fainting, irregular heartbeat, or signs of an allergic reaction.

Cosimprel should not be used by patients with certain medical conditions, such as severe liver disease, severe kidney disease, or a history of allergic reactions to beta-blockers or ACE inhibitors. It should also be avoided in patients with asthma or COPD unless clearly necessary and under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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