Product image of Coxor (Acetylsalicylic Acid) 300 mg Powder and liquid for oral solution supplied by GNH India

Coxor

Active Ingredient:
Acetylsalicylic Acid
Form:
Powder and liquid for oral solution
Origin:
EU

Coxor (Acetylsalicylic Acid Powder and liquid for oral solution) 300 mg

Coxor is a single-dose emergency medicine containing 300 mg acetylsalicylic acid, supplied as a powder and liquid for oral solution in a self-contained bottle. It is authorised for the emergency treatment of a suspected acute heart attack (acute myocardial infarction) in adults over 18 years, to be taken as soon as possible after contacting emergency medical services. The active substance is held as a white powder in the bottle cap; it is released into the liquid and shaken until dissolved immediately before drinking. Coxor is not an everyday painkiller. Marketing authorisation holder: Asamedic AS, Rosenholmveien 25, 1414 Trollasen, Norway. In Norway this product is authorised under marketing authorisation number 19-13231 (first authorised 29 March 2021, last renewed 19 January 2026); patients are advised to call 113 before taking the dose.

Strength

300 mg

Pack Size

1 bottle (15 ml liquid + 300 mg powder in the bottle cap)

Storage

Do not freeze. Shelf life 2 years.

Manufacturer / TM Owner

Asamedic As

1
Pack/s
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Indications & Clinical Uses

  • Coxor is indicated in adults over 18 years for the emergency treatment of a suspected acute myocardial infarction (heart attack), after contacting emergency medical services. A single 300 mg dose (one bottle) should be taken as soon as possible. If emergency services cannot be reached, the dose should still be taken as soon as possible and immediate medical attention sought. Coxor is not indicated as an analgesic or antipyretic, and is not relevant for use in the paediatric population.

How It Works

  • Acetylsalicylic acid is an antithrombotic agent and platelet aggregation inhibitor (ATC code B01AC06). It irreversibly inhibits fatty-acid cyclooxygenase by acetylating the active site of the enzyme, reducing formation of thromboxanes, prostaglandins and prostacyclin, and prolonging bleeding time. Because platelets cannot resynthesise the enzyme, the effect lasts their full 8-day lifespan. Absorption after oral administration is rapid (80-100% of the dose); soluble formulations reach peak plasma concentrations markedly faster than plain or coated tablets. The plasma half-life of acetylsalicylic acid is approximately 15-20 minutes, with a serum salicylate half-life of about 2-3 hours at a 325 mg dose.

Side Effects

  • Because Coxor is given as a single 300 mg dose in an acute setting, the risk of adverse reactions is very low; the reactions listed below were identified in long-term studies of acetylsalicylic acid. Common: increased bleeding tendency. Uncommon: dyspnoea. Rare: hypersensitivity reactions, angioedema, allergic oedema, anaphylactic reactions including shock; intracerebral haemorrhage; haemorrhagic vasculitis; bronchospasm and asthma attack; severe gastrointestinal bleeding; Stevens-Johnson syndrome, toxic epidermal necrolysis, purpura, erythema nodosum, erythema multiforme; menorrhagia. Not known: bleeding with prolonged bleeding time such as nosebleed or gingival bleeding. Occult blood in the stool may be found on investigation.

Precautions & Warnings

  • Contraindicated in patients hypersensitive to acetylsalicylic acid, to any excipient, or to other salicylates or NSAIDs. Acetylsalicylic acid can cause bronchospasm and asthma attacks or other hypersensitivity reactions; risk factors include asthma, hay fever, nasal polyps and chronic lung disease. It is associated with bleeding, so possible bleeding should be monitored on admission to hospital. Each bottle contains 595 mg (26 mmol) sodium, equivalent to 30% of the WHO recommended maximum daily intake of 2 g sodium for an adult. Acetylsalicylic acid may be used in pregnancy as emergency treatment of a suspected acute myocardial infarction where necessary, but must not be used as a painkiller or fever reducer in pregnancy; short-term use of the recommended dose does not require breastfeeding to be interrupted. Treatment of an acute myocardial infarction is not compatible with driving or operating machinery. Taking Coxor is not dangerous if the symptoms turn out not to be a heart attack. Toxic dose is approximately 200 mg/kg in adults; single doses below 100 mg/kg are unlikely to cause serious poisoning. Once reconstituted, the solution must be drunk within 5 minutes.

Avoid Interactions

  • Anticoagulants (for example coumarin, heparin, warfarin): increased risk of bleeding due to inhibited platelet function, damaged duodenal mucosa and displacement of oral anticoagulants from plasma protein binding sites; bleeding time should be monitored when the patient is admitted to hospital. Antiplatelet agents (for example clopidogrel and dipyridamole) and selective serotonin reuptake inhibitors (such as sertraline or paroxetine): increased risk of gastrointestinal bleeding, which can be monitored in hospital. Other NSAIDs: increased risk of ulcers and gastrointestinal bleeding through a synergistic effect, which can be monitored in hospital.

Frequently Asked Questions

Coxor is used in adults over 18 as emergency treatment when an acute heart attack is suspected, after contacting emergency medical services. It is not a general painkiller or fever reducer.

Turn the cap CLOCKWISE - the opposite of opening a normal bottle. You will hear a faint click as the safety ring breaks, but the powder has not dropped yet; keep turning clockwise another 3-4 turns until the cap meets the bottle neck and stops. The white powder falls into the liquid and is visible in the window. Shake for about 30 seconds until dissolved, then open the cap anticlockwise and drink immediately.

Within 5 minutes of reconstitution. The solution turns slightly cloudy or stays clear; the colour of the liquid does not change.

Take the dose anyway, as soon as possible, and then seek immediate medical attention. Taking Coxor is not dangerous if the symptoms turn out not to be a heart attack.

Anyone hypersensitive to acetylsalicylic acid, to any excipient, or to other salicylates or NSAIDs. Caution applies in asthma, hay fever, nasal polyps or chronic lung disease, as acetylsalicylic acid can trigger bronchospasm.

595 mg (26 mmol) of sodium per bottle, which is 30% of the WHO recommended maximum daily intake of 2 g for an adult.

It may be used in pregnancy as emergency treatment of a suspected heart attack if necessary, but not as a painkiller or fever reducer. Short-term use of the recommended dose does not require breastfeeding to be interrupted.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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