CYRAMZA-500 - Ramucirumab

Storage/Handling:

Store in the refrigerator between 2°C - 8°C away from moisture and direct sunlight. Do not freeze.

Uses of CYRAMZA-500 - Ramucirumab:

Cyramza is used in the treatment of -
1. Non-small cell lung cancer
2. Stomach cancer
3. Cancer of colon and rectum

Product Introduction:

Cyramza 500mg Injection is an anticancer medication. It is used in the treatment of non-small cell lung cancer, stomach cancer and cancer of colon and rectum.

Cyramza 500mg Injection contains Ramucirumab as an active ingredient, which belongs to the class of monoclonal antibodies. It works by inhibiting the abnormal growth of cancer cells and, finally, causes the initiation of programmed cell death.

Cyramza 500mg Injection may cause some side effects, such as abdominal pain, dry mouth, mouth sores, increased blood pressure, diarrhea, fatigue, nausea, headache, nose bleeds, vomiting, tiredness, and injection site reactions. If the side effects persist or bother you, please consult your doctor. Cyramza 500mg Injection will be administered by a doctor experienced in the administration of cancer medicine. Do not self-administer.

It is given as IV infusion into vein by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised.

Benefits of CYRAMZA-500 - Ramucirumab:

a. Non-small cell lung cancer (NSCLC):
Cyramza may be used in combination with other chemotherapy drugs for the treatment of advanced NSCLC that has progressed after initial platinum-based chemotherapy. It works by blocking a protein that helps tumors grow and spread. While it may not shrink tumors significantly, Cyramza can help slow down their growth and improve progression-free survival (time without the cancer worsening).

b. Stomach cancer:
Cyramza is used in combination with another medication called paclitaxel for the treatment of advanced stomach cancer that has already spread (metastatic) or has come back (recurrent) after prior treatment. Similar to NSCLC, Cyramza doesn't necessarily shrink tumors dramatically, but it can help delay their growth and extend progression-free survival.

c. Cancer of colon and rectum (colorectal cancer):
Cyramza 500mg Injection effectively treats and reduces the risk of additional cancerous growths (polyps) and bowel cancer. It works by eliminating or halting the growth of cancer cells while also inhibiting their multiplication. However, it is important to note that this medication is potent and may have toxic effects. Therefore, it's crucial to have a discussion with your doctor regarding the potential risks and benefits. During the course of treatment, it's advisable to refrain from alcohol consumption and smoking, and to maintain hydration by drinking plenty of water.

Side Effects of CYRAMZA-500 - Ramucirumab:

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them.

Common side effects of Cyramza ramucirumab 500mg-
#Nausea
#Vomiting
#Diarrhea
#Nose bleeds
#Headache
#Fatigue
#Injection site reactions
#Pain at the site of injection
#Increased blood pressure
#Dry mouth
#Mouth sores
#Fever
#Back pain

Drug Interactions:

Other drugs may interact with ramucirumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

How CYRAMZA-500 - Ramucirumab Works:

Cyramza 500mg (ramucirumab) works by hindering the growth and spread of cancer cells. It achieves this through a specific mechanism targeting a process called angiogenesis.

Angiogenesis is essentially the formation of new blood vessels. Tumors require a constant supply of blood to obtain oxygen and nutrients for their growth and survival. Cyramza acts as an antiangiogenic therapy by targeting a protein called vascular endothelial growth factor receptor 2 (VEGFR2).

VEGFR2 plays a critical role in signaling the growth of new blood vessels. Cyramza binds to VEGFR2, blocking its function and thereby inhibiting the formation of new blood vessels that would nourish the tumor.

Safety Instructions For CYRAMZA-500 - Ramucirumab:

ALCOHOL Caution Avoid consuming alcohol while undergoing Cyramza treatment. Alcohol can increase the levels of Cyramza in your blood, potentially magnifying side effects.   PREGNANCY Unsafe Cyramza is strictly contraindicated during pregnancy. It can cause severe harm to your unborn baby. Discuss alternative treatment options with your doctor if you are pregnant or trying to conceive.   Driving and Operating Machinery Exercise Caution Cyramza may cause fatigue or dizziness in some individuals. It's crucial to exercise caution when driving or operating machinery until you know how this medication affects you. Discuss these concerns with your doctor.   LIVER Safe If Pescribed Cyramza 500mg Injection is safe to use in patients with liver disease. However, inform your doctor about any existing liver problems before starting Cyramza. Your doctor may need to adjust your dosage or monitor your liver function more closely if you have liver issues.   KIDNEY Safe If Pescribed Cyramza 500mg Injection is safe to use in patients with kidney disease but it is advised to disclose any kidney problems to your doctor. Kidney function may be monitored during Cyramza treatment and dosage adjustments might be necessary.   CHILDREN Not recommended Cyramza 500mg injection is not approved for use in children.

Habit Forming

No

Remember:

1. Allergic Reactions: Be aware of potential allergic reactions to Cyramza 500mg. Inform your doctor immediately if you experience symptoms like hives, wheezing, or difficulty breathing.

2. Bleeding Risk: Cyramza 500 can increase your risk of bleeding. Tell your doctor about any bleeding problems you have or any medications or supplements that could increase bleeding risk (e.g., blood thinners).

3. Infection Risk: Cyramza ramucirumab may weaken your immune system, making you more susceptible to infections. Practice good hygiene and inform your doctor promptly if you develop signs of infection (fever, chills, etc.).

4. Wound Healing: Cyramza may delay wound healing. Discuss any upcoming surgeries with your doctor beforehand.

5. Regular Monitoring: Your doctor will schedule regular appointments to monitor your progress and check for side effects during Cyramza 500mg treatment.

6. Do not skip doses: It's crucial to maintain a consistent dosing schedule for Cyramza to be effective.

FAQs:

1. What is Cyramza used for?

Cyramza is used in combination with other medications to treat specific types of advanced cancer, including:
1. Non-small cell lung cancer (NSCLC)
2. Stomach cancer
3. Cancer of colon and rectum cancer

2. How is Cyramza given?

Cyramza is administered intravenously (through a vein) by a healthcare professional. The typical dosage is 500mg every 6 weeks.

3. What are the serious side effects of Cyramza 500mg?

Serious side effects of Cyramza 500mg can include:
1. Severe bleeding
2. Gastrointestinal perforation (hole in your stomach or intestine)
3. Impaired wound healing
4. High blood pressure crisis

4. I am pregnant/breastfeeding, can I take Cyramza 500?

Cyramza 500 can harm your unborn baby and is not recommended during pregnancy. It's also not recommended for breastfeeding mothers. Discuss alternative treatment options with your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

5. What should I tell my doctor before starting Cyramza drug?

Before starting Cyramza drug, inform your doctor about:
1. Any allergies, especially to other monoclonal antibodies
2. Existing medical conditions, including liver or kidney problems, high blood pressure, or bleeding disorders
3. Recent or upcoming surgeries
4 Current medications (prescription, over-the-counter, vitamins, herbs)
5. Pregnancy status or plans to become pregnant
6. Breastfeeding status

6. What is Cyramza 500 administration?

Cyramza 500mg is administered intravenously (through a vein) by a healthcare professional in a hospital or clinic setting. The usual dose of Cyramza is 500mg, given every 2 weeks (14 days) as an intravenous infusion. In some cases, the doctor may adjust the dosage based on your individual needs and tolerability.