Gracial Associação (Desogestrel, Ethinylestradiol)

Gracial Associação is indicated for the prevention of pregnancy in women of reproductive age.

• As a combined oral contraceptive taken daily to inhibit ovulation.
• For cycle regulation and reduction of menstrual‑related symptoms.
• To decrease the risk of ovarian cyst formation.
• May be used as part of hormone therapy after childbirth when estrogen is indicated.
• Provides reliable contraception when taken as directed.

Side effects reported with Gracial Associação vary in frequency and severity.

Common

• Nausea, mild stomach upset, or loss of appetite.
• Headache, migraine‑like pain, or visual disturbances.
• Breast tenderness, swelling, or a feeling of fullness.
• Irregular spotting, breakthrough bleeding, or delayed periods.
• Mood swings, mild depressive symptoms, or irritability.
• Slight weight gain, fluid retention, or bloating.

Serious

• Blood clots such as deep vein thrombosis, pulmonary embolism, or stroke.
• Severe allergic reactions including rash, swelling of the face or throat, or difficulty breathing.

Before prescribing Gracial Associação, clinicians consider several precautions to ensure safe use.

• Not for women who are pregnant or planning pregnancy during treatment.
• Contraindicated in individuals with a history of thromboembolic disorders.
• Caution in smokers over 35 years of age due to increased cardiovascular risk.
• Evaluate liver disease, hypertension, or diabetes before initiation.
• Review any history of migraine with aura.
• Use additional barrier contraception when starting or after missing pills.

Gracial Associação may interact with other medicines, affecting its effectiveness or safety.

Avoid

• Strong enzyme‑inducing antiepileptics such as carbamazepine, phenytoin, phenobarbital, or rifampin, which can lower contraceptive hormone levels.
• Rifampicin and other potent antibiotics that increase hepatic metabolism of ethinylestradiol and desogestrel.

Use with caution

• Antifungal agents like ketoconazole or itraconazole that may raise estrogen concentrations and increase side‑effect risk.
• Herbal supplements such as St. John’s wort that induce CYP3A4 and could reduce contraceptive efficacy.
• Certain antiviral medications, including protease inhibitors or non‑nucleoside reverse transcriptase inhibitors, which may alter hormone metabolism.