Isopto®-Dex (Dexamethasone)

Dexamethasone acts as a glucocorticoid receptor agonist. After binding to receptors inside ocular cells, it alters gene expression to suppress inflammatory mediators, decrease leukocyte migration, and stabilise cellular membranes, thereby reducing inflammation and immune activity in the eye.

The specific dosing regimen for Isopto-Dex is determined by the prescribing ophthalmologist based on the severity of the condition, patient response, and treatment duration. The prescriber will provide detailed instructions on the number of drops and frequency.

The safety of Isopto-Dex in pregnancy and lactation has not been definitively established. Healthcare providers should weigh potential benefits against possible risks and consider alternative therapies when appropriate.

To request Isopto-Dex, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Isopto-Dex contains dexamethasone, a potent corticosteroid with a rapid anti‑inflammatory onset. Compared with weaker agents like prednisolone acetate, dexamethasone often requires a shorter treatment course but may carry a higher risk of intra‑ocular pressure elevation, necessitating careful monitoring.

Isopto-Dex should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from light and moisture, and discard any suspension that has changed in appearance or is past its expiration date.

Isopto-Dex is applied as an ophthalmic suspension. The patient tilts the head back, gently pulls down the lower eyelid, and instills the prescribed number of drops into the conjunctival sac. The eye should be closed gently for a few seconds to allow even distribution.

Serious risks include a significant rise in intra‑ocular pressure leading to glaucoma, cataract formation with prolonged use, and secondary ocular infections. Patients should be monitored regularly for visual changes, pressure spikes, and signs of infection.

Isopto-Dex is contraindicated in patients with known hypersensitivity to dexamethasone or any component of the formulation, and it should be avoided in active viral ocular infections such as herpes simplex keratitis. Caution is also advised for individuals with uncontrolled glaucoma.