Dicloflex (Diclofenac Sodium)

Dicloflex is applied to the skin to manage localized pain and inflammation associated with musculoskeletal conditions.

• Relief of mild to moderate pain from osteoarthritis of the knee or other joints.
• Reduction of inflammation and discomfort from sprains, strains, and bruises.
• Management of tendonitis or bursitis symptoms in the affected area.
• Adjunctive therapy for postoperative or post‑traumatic pain where oral NSAIDs are unsuitable.
• Temporary relief of back or shoulder muscle aches.

Topical diclofenac may cause skin‑related and systemic side effects, most of which are mild and reversible.

Common

• Local skin irritation, redness, or itching at the application site.
• Burning or stinging sensation shortly after application.
• Dryness or peeling of the treated skin.
• Mild headache.

Serious

• Allergic skin reactions such as rash, hives, or swelling.
• Severe skin ulceration or necrosis.
• Signs of systemic NSAID toxicity (e.g., gastrointestinal bleeding, dizziness).
• Liver enzyme elevation or hepatic dysfunction.

When using Dicloflex, certain precautions help minimize risks and ensure safe use.

• Apply only to intact, unbroken skin and avoid mucous membranes.
• Do not cover the treated area with occlusive dressings unless directed by a healthcare professional.
• Limit use to the recommended duration, typically not exceeding 7‑10 days without medical advice.
• Avoid use on large body surface areas to reduce systemic absorption.
• Discontinue if signs of allergic reaction or severe skin irritation develop.
• Consult a physician before use in patients with known cardiovascular, renal, or hepatic disease.
• Keep out of reach of children; accidental ingestion may cause systemic NSAID effects.

Dicloflex can interact with other medicines, especially those that affect bleeding, kidney function, or systemic NSAID exposure.

Avoid

• Concurrent use of oral or injectable NSAIDs, aspirin, or anticoagulants (e.g., warfarin, clopidogrel) that increase bleeding risk.
• Systemic corticosteroids or other anti‑inflammatory agents that may heighten gastrointestinal toxicity.
• Other topical products containing diclofenac or similar NSAIDs, which could raise total diclofenac exposure.

Use with caution

• Diuretics or ACE inhibitors in patients with renal impairment, as NSAIDs can affect kidney function.
• Lithium therapy, because NSAIDs may increase lithium serum levels.
• Methotrexate, as NSAIDs can reduce its clearance.
• Antihypertensive medications, where NSAIDs might blunt their effect.