Product image of Lanacordin Pediátrico (Digoxin) supplied by GNH India

Lanacordin Pediátrico

Active Ingredient:
Digoxin
Origin:
EU

Lanacordin Pediátrico (Digoxin)

Digoxin, the active ingredient in Lanacordin Pediátrico, is a cardiac glycoside presented as an oral formulation for oral use. It is employed to improve cardiac contractility in heart failure and to control ventricular rate in atrial fibrillation, particularly in pediatric patients.

GNH India supplies Lanacordin Pediátrico as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for export to multiple regions. This includes compliance with EU GMP guidelines and traceability throughout the supply chain.

Manufacturer / TM Owner

Kern Pharma, S.L.

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Indications & Clinical Uses

Digoxin acts on the cardiac conduction system and myocardial contractility, providing therapeutic benefit in specific cardiovascular conditions.

  • Heart failure: improves cardiac output and reduces symptoms of congestion.
  • Atrial fibrillation (rate control): slows atrioventricular nodal conduction to achieve ventricular rate control.
  • Atrial flutter (rate control): reduces ventricular response by decreasing AV nodal transmission.
  • Supraventricular tachycardia: helps control heart rate when other agents are unsuitable.

How It Works

  • Digoxin binds to and inhibits the Na⁺/K⁺‑ATPase pump on cardiac myocyte membranes, leading to an increase in intracellular sodium. The elevated sodium reduces the activity of the sodium‑calcium exchanger, causing intracellular calcium accumulation. Higher calcium availability enhances contractile force (positive inotropic effect) and prolongs the refractory period of the atrioventricular node, thereby slowing conduction and reducing heart rate overall cardiac performance.

Side Effects

Digoxin may cause a range of adverse reactions, varying from mild to potentially life‑threatening.

Common Side Effects

  • Nausea or vomiting: gastrointestinal upset that may be transient.
  • Diarrhea: loose stools that can lead to dehydration.
  • Fatigue or weakness: reduced energy levels and muscle strength.
  • Blurred vision or color disturbances: visual changes such as yellow‑green halos.

Serious or Rare Side Effects

  • Cardiac arrhythmias including ventricular tachycardia: potentially life‑threatening rhythm disturbances.
  • Severe bradycardia or AV block: markedly slowed heart rate or conduction block.
  • Hyperkalemia: elevated serum potassium that can exacerbate toxicity.
  • Allergic reactions such as rash or anaphylaxis: immune‑mediated responses requiring immediate care.

Precautions & Warnings

When prescribing digoxin, clinicians should observe several safety measures to minimize toxicity and ensure therapeutic effectiveness.

  • Monitor serum digoxin levels: adjust dose based on therapeutic range.
  • Assess renal function: impaired clearance increases risk of accumulation.
  • Check electrolytes, especially potassium and magnesium: abnormalities heighten toxicity.
  • Use caution in elderly patients: age‑related pharmacokinetic changes may require lower doses.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Digoxin interacts with several medicines; awareness of these relationships helps avoid adverse events.

Major Interactions (Avoid)

  • Amiodarone: markedly increases digoxin concentration.
  • Quinidine: potentiates digoxin effect and toxicity.
  • Verapamil: raises digoxin levels and may cause bradyarrhythmias.

Moderate Interactions (Monitor Closely)

  • Diuretics (especially thiazides): can cause electrolyte shifts that enhance toxicity.
  • ACE inhibitors: may increase digoxin levels modestly.
  • NSAIDs: may reduce renal clearance and elevate serum concentrations.

Frequently Asked Questions

Lanacordin Pediátrico contains digoxin, which is used to treat heart failure by improving cardiac contractility and to control ventricular rate in atrial fibrillation and atrial flutter. It is prescribed when rate control or inotropic support is needed, particularly in pediatric patients under specialist supervision.

Digoxin inhibits the Na⁺/K⁺‑ATPase pump on heart muscle cells, raising intracellular sodium. This reduces the sodium‑calcium exchanger activity, leading to increased calcium inside the cells. The extra calcium strengthens heart contractions (positive inotropic effect) and prolongs AV‑node refractory period, slowing electrical conduction and reducing heart rate.

The appropriate dose of Lanacordin Pediátrico is determined by the prescribing clinician based on the patient’s age, weight, renal function, electrolyte status and therapeutic response. Dosage regimens are individualized and must follow the prescriber’s instructions and local clinical guidelines.

Digoxin is classified as Pregnancy Category C, indicating that risk to the fetus cannot be ruled out and the drug should be used only if the potential benefit justifies the potential risk. Limited data are available for breastfeeding, and a decision should be made by the healthcare provider after weighing benefits and risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Lanacordin Pediátrico. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Digoxin provides a unique positive inotropic effect and rate‑control property that differs from ACE inhibitors, beta‑blockers or diuretics, which mainly modify neuro‑hormonal pathways or fluid balance. It is often used as an adjunct when additional contractile support or ventricular rate control is required, but it does not replace first‑line guideline‑directed therapies.

Lanacordin Pediátrico should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and excessive heat. Ensure the container is tightly closed to maintain stability and protect from humidity.

The medication is taken orally, usually as a tablet or liquid preparation, according to the prescriber’s directions. It may be taken with or without food, but consistency with respect to meals helps maintain stable absorption. Patients should follow the exact dosing schedule provided by their healthcare professional.

The most serious risks include cardiac arrhythmias such as ventricular tachycardia, severe bradycardia, and AV block, which can be life‑threatening. Signs of toxicity—nausea, vomiting, visual disturbances, confusion, or irregular heartbeat—should prompt immediate medical evaluation.

Lanacordin Pediátrico is contraindicated in patients with known hypersensitivity to digoxin or other cardiac glycosides, those with uncontrolled ventricular arrhythmias, and individuals with severe renal impairment without dose adjustment. Caution is also advised for patients with electrolyte imbalances, especially low potassium or magnesium.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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