Product image of Lenoxin® (Digoxin) supplied by GNH India

Lenoxin®

Active Ingredient:
Digoxin
Origin:
EU

Lenoxin® (Digoxin)

Digoxin, the active ingredient in Lenoxin®, is a cardiac glycoside presented as an oral dosage form for oral use. It is used to improve cardiac contractility and control heart rate in patients with heart failure and atrial fibrillation.
GNH India supplies Lenoxin® as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

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Indications & Clinical Uses

  • Digoxin acts on the cardiac conduction system and myocardial contractility to treat specific cardiovascular conditions.
  • Heart failure: improves cardiac output and reduces symptoms of fluid overload.
  • Atrial fibrillation: helps control ventricular rate and restores sinus rhythm in selected patients.

How It Works

  • Digoxin binds to and inhibits the Na⁺/K⁺‑ATPase pump on cardiac myocytes, leading to an increase in intracellular sodium. The elevated sodium reduces the activity of the Na⁺/Ca²⁺ exchanger, causing intracellular calcium accumulation, which enhances myocardial contractility (positive inotropic effect). Additionally, digoxin increases vagal tone, slowing atrioventricular nodal conduction and providing rate control in atrial arrhythmias.

Side Effects

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

  • Nausea or vomiting
  • Diarrhea
  • Fatigue or weakness
  • Dizziness or light‑headedness
  • Blurred or yellow‑green vision
  • Headache

Serious or Rare Side Effects

  • Life‑threatening arrhythmias (e.g., ventricular tachycardia)
  • Severe bradycardia or heart block
  • Hyperkalemia
  • Allergic reactions such as rash or angioedema
  • Persistent visual disturbances (e.g., halos)
  • Confusion or hallucinations

Precautions & Warnings

  • Before initiating digoxin therapy, several safety considerations are recommended.
  • Monitor serum digoxin levels: adjust dose based on therapeutic range.
  • Assess renal function: dose reduction may be needed in impairment.
  • Correct electrolyte abnormalities: especially potassium, magnesium, and calcium.
  • Avoid use in patients with ventricular fibrillation or advanced AV block without a pacemaker.
  • Use with caution during pregnancy and lactation; benefits must outweigh potential risks.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Digoxin has a narrow therapeutic index and interacts with several medicines.

Major Interactions (Avoid)

  • Amiodarone: markedly increases digoxin concentrations.
  • Quinidine: raises serum digoxin levels and risk of toxicity.
  • Verapamil: enhances digoxin effect and may cause bradycardia.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: may cause electrolyte shifts that predispose to toxicity.
  • ACE inhibitors: can increase digoxin levels modestly.
  • NSAIDs: may reduce renal clearance of digoxin, necessitating monitoring.

Frequently Asked Questions

Lenoxin® contains digoxin, which is prescribed to improve heart muscle contractility in chronic heart failure and to control ventricular rate in atrial fibrillation. It may also be used in selected cases to restore normal heart rhythm.

Digoxin inhibits the Na⁺/K⁺‑ATPase pump in cardiac cells, raising intracellular sodium and consequently calcium levels. This enhances the force of contraction and increases vagal tone, slowing conduction through the atrioventricular node and helping to regulate heart rhythm.

The specific dose of digoxin is individualized by the prescribing clinician based on factors such as age, kidney function, body weight, and serum electrolyte status. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data are limited; digoxin should only be used during pregnancy or lactation if the potential benefit justifies the possible risk to the fetus or infant. The prescriber will evaluate the risk‑benefit profile for each patient.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Digoxin provides a unique positive inotropic effect and rate‑control benefit that differs from ACE inhibitors, beta‑blockers, or diuretics, which mainly reduce workload or fluid overload. It is often added when symptoms persist despite standard therapy, but its narrow therapeutic window requires careful monitoring.

Store Lenoxin® at room temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Lenoxin® is taken orally, usually with or without food, as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.

The most serious risks include cardiac arrhythmias such as ventricular tachycardia or severe bradycardia, heart block, and digoxin toxicity manifested by nausea, visual disturbances, and confusion. Prompt medical attention is required if any of these symptoms occur.

Patients with ventricular fibrillation, advanced atrioventricular block without a pacemaker, severe renal impairment, or uncontrolled electrolyte abnormalities should generally avoid digoxin. The prescriber will assess individual contraindications before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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