Product image of Lenoxin® Mite (Digoxin) supplied by GNH India

Lenoxin® Mite

Active Ingredient:
Digoxin
Origin:
EU

Lenoxin® Mite (Digoxin)

Digoxin, the active ingredient in Lenoxin® Mite, is a cardiac glycoside presented as an oral dosage form (strength not disclosed) for oral use. It is used to improve cardiac contractility in heart failure and to control ventricular rate in atrial fibrillation, primarily in adult patients.
GNH India supplies Lenoxin® Mite as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aspen Pharma Trading Limited

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Indications & Clinical Uses

Digoxin acts on the cardiac conduction system and myocardial contractility, making it useful in several cardiovascular conditions.

  • Heart failure: increases cardiac output and reduces symptoms of congestion.
  • Atrial fibrillation (rate control): slows ventricular response to improve heart rate control.
  • Supraventricular tachycardia: may help control ventricular rate when other measures are insufficient.

How It Works

  • Digoxin inhibits the Na⁺/K⁺‑ATPase pump on cardiac myocytes, leading to an increase in intracellular sodium. This alteration reduces the activity of the sodium‑calcium exchanger, causing intracellular calcium accumulation, which enhances myocardial contractility (positive inotropic effect). Additionally, digoxin modulates autonomic tone by increasing vagal activity, thereby slowing atrioventricular nodal conduction and reducing heart rate.

Side Effects

Adverse reactions to digoxin vary in frequency and severity.

Common Side Effects

  • Nausea: gastrointestinal upset that may be mild to moderate.
  • Fatigue: generalized tiredness often reported by patients.
  • Visual disturbances: blurred vision or color perception changes.
  • Headache: occasional mild headache.

Serious or Rare Side Effects

  • Cardiac arrhythmias: potentially life‑threatening rhythm disturbances.
  • Severe bradycardia: markedly slowed heart rate requiring medical attention.
  • Hyperkalemia: elevated serum potassium that can exacerbate toxicity.
  • Allergic skin reactions: rash or urticaria indicating hypersensitivity.

Precautions & Warnings

When prescribing digoxin, clinicians should consider several safety factors.

  • Renal function: adjust dose in patients with impaired clearance.
  • Electrolyte balance: monitor potassium and magnesium levels to avoid toxicity.
  • Thyroid disease: use caution in hyperthyroid patients as they may be more sensitive.
  • Drug level monitoring: obtain serum digoxin concentrations to stay within therapeutic range.
  • Pregnancy and lactation: evaluate risk versus benefit before use.
  • Store at below 25°C: keep in the original container, protect from moisture.

Avoid Interactions

Digoxin interacts with several medicines that can alter its plasma concentration or cardiac effects.

Major Interactions (Avoid)

  • Amiodarone: markedly increases digoxin levels.
  • Quinidine: raises digoxin concentrations and risk of toxicity.
  • Verapamil: enhances digoxin exposure and may cause bradycardia.
  • Spironolactone: can potentiate digoxin toxicity.

Moderate Interactions (Monitor Closely)

  • Loop and thiazide diuretics: affect electrolyte balance, influencing digoxin safety.
  • Beta‑blockers: additive effect on heart rate and AV nodal conduction.
  • Macrolide antibiotics (e.g., erythromycin): may modestly increase digoxin levels.

Frequently Asked Questions

Lenoxin® Mite contains digoxin, a cardiac glycoside prescribed to improve heart muscle contraction in chronic heart failure and to control ventricular rate in patients with atrial fibrillation. It is used in adult patients when other therapies are insufficient or as part of a combination regimen to achieve optimal cardiac function.

Digoxin inhibits the sodium‑potassium ATPase pump on cardiac cells, raising intracellular sodium. This change reduces the activity of the sodium‑calcium exchanger, leading to increased calcium within the heart muscle, which strengthens contraction. It also enhances vagal tone, slowing conduction through the atrioventricular node and helping to regulate heart rate.

The appropriate dose of Lenoxin® Mite is individualized by the prescribing clinician based on the patient’s age, renal function, electrolyte status, and therapeutic response. Dosage adjustments are made after evaluating serum digoxin concentrations and clinical effect, and patients should follow the prescriber’s specific instructions.

Safety of digoxin in pregnancy and lactation has not been definitively established. It may be used if the potential benefit justifies the potential risk to the fetus or infant. Clinicians should assess each case carefully, and breastfeeding mothers should discuss possible exposure with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Lenoxin® Mite. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Digoxin provides a unique positive inotropic effect and rate‑controlling properties not shared by many other heart‑failure agents such as ACE inhibitors or beta‑blockers. While it can improve symptoms and reduce hospitalizations, it does not replace guideline‑directed therapies and is typically added when additional control of heart rate or contractility is needed.

Lenoxin® Mite should be stored at temperatures below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments.

Lenoxin® Mite is taken orally, usually with or without food as directed by the prescriber. The tablet should be swallowed whole with a glass of water. Patients should not crush, chew, or split the tablet unless specifically instructed by a healthcare professional.

The most serious risks include digoxin toxicity, which can manifest as severe cardiac arrhythmias, marked bradycardia, and life‑threatening conduction disturbances. Electrolyte imbalances, especially low potassium or high calcium, can increase toxicity risk. Prompt medical evaluation is essential if symptoms such as visual changes, nausea, or irregular heartbeat occur.

Lenoxin® Mite should be avoided in patients with known hypersensitivity to digoxin or other cardiac glycosides, in those with uncontrolled ventricular arrhythmias, and in individuals with severe renal impairment without appropriate dose adjustment. Clinicians should also exercise caution in patients with significant electrolyte disturbances or advanced heart block.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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