Normostop Cafeína (Dimenhydrinate, Caffeine)

Dimenhydrinate/Caffeine acts on the vestibular and central pathways that trigger nausea and vomiting.

• Motion sickness: reduces vertigo‑induced nausea and vomiting.
• Nausea: alleviates acute nausea from various non‑specific causes.
• Vomiting: helps control episodes of vomiting associated with vestibular disturbances.

• Dimenhydrinate blocks H1 histamine receptors and exerts anticholinergic activity, diminishing vestibular stimulation and the central nausea response. Caffeine antagonizes adenosine receptors, increasing neuronal firing and counteracting the sedative effect of dimenhydrinate, while also providing mild stimulant activity that can improve alertness during travel.

Adverse reactions may occur with any antihistamine‑stimulant combination.

Common Side Effects

• Drowsiness or mild sedation
• Dry mouth or throat
• Blurred vision
• Constipation or stomach discomfort
• Increased heart rate or palpitations
• Restlessness or mild anxiety

Serious or Rare Side Effects

• Severe allergic reaction (anaphylaxis, rash, swelling)
• Cardiac arrhythmias or tachycardia
• Seizures
• Hallucinations or severe confusion
• Persistent vomiting despite therapy

When using Dimenhydrinate/Caffeine, consider the following safety measures.

• Pediatric Use: avoid in children under 2 years unless directed by a physician.
• Driving and Machinery: do not operate vehicles or heavy equipment until you know how the product affects you.
• Alcohol: avoid concurrent consumption as it may enhance drowsiness.
• Pre‑existing Conditions: use with caution in patients with glaucoma, urinary retention, or cardiovascular disease.
• Pregnancy and Breastfeeding: consult a healthcare professional before use.
• Store at ambient temperature: keep in the original container, protect from moisture and heat.

Dimenhydrinate/Caffeine can affect the activity of several other medicines.

Major Interactions (Avoid)

• Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
• Other central nervous system depressants (e.g., benzodiazepines, opioids): enhanced sedation.
• Anticholinergic drugs (e.g., atropine, ipratropium): additive anticholinergic effects.
• Certain antidepressants (e.g., tricyclics): increased cardiac side effects.
• Alcohol: potentiates drowsiness and dizziness.

Moderate Interactions (Monitor Closely)

• Antihypertensive agents: caffeine may reduce blood‑pressure‑lowering effect.
• Antidiabetic drugs: possible alteration of glucose control.
• Other stimulants (e.g., pseudoephedrine): may increase heart rate and anxiety.
• Warfarin: caffeine may affect INR stability.
• Antiepileptic drugs: potential for reduced seizure threshold.