Product image of Dormax 500Mg Inj (Doripenem) 500 MG SOLUTION supplied by GNH India

Dormax 500Mg Inj

Active Ingredient:
Doripenem
Form:
SOLUTION

Dormax 500Mg Inj (Doripenem SOLUTION) 500 MG

Doripenem, the active ingredient in Dormax 500Mg Inj, is a carbapenem antibiotic presented as a 500 mg injection solution for IV use. It treats complicated intra‑abdominal infections, complicated urinary tract infections, and hospital‑acquired pneumonia in hospitalized adult patients.

GNH India supplies Dormax 500Mg Inj as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Strength

500 MG

1
Pack/s
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Indications & Clinical Uses

Doripenem is a carbapenem antibiotic used to treat serious bacterial infections in hospitalized patients.

  • Complicated intra‑abdominal infections: achieves clinical cure and microbiological eradication.
  • Complicated urinary tract infections: provides bacterial clearance and symptom resolution.
  • Hospital‑acquired (nosocomial) pneumonia: improves outcomes by targeting resistant Gram‑negative and Gram‑positive pathogens.

How It Works

  • Doripenem inhibits bacterial cell wall synthesis by binding with high affinity to penicillin‑binding proteins (PBPs). This binding blocks the transpeptidation step of peptidoglycan cross‑linking, leading to loss of cell wall integrity and bacterial cell death. The drug is stable against most β‑lactamases, including extended‑spectrum enzymes, which contributes to its broad spectrum activity.

Side Effects

Doripenem may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Diarrhea: mild to moderate watery stools.
  • Nausea: occasional feeling of queasiness.
  • Headache: transient cranial discomfort.
  • Elevated liver enzymes: mild increase in ALT/AST.

Serious or Rare Side Effects

  • Seizures: risk increased in patients with renal impairment or CNS disorders.
  • Severe allergic reactions: anaphylaxis, rash, or angioedema.
  • Clostridioides difficile colitis: potentially life‑threatening diarrhea.

Precautions & Warnings

When using Doripenem, clinicians should consider several safety and handling precautions.

  • Renal function: adjust dose in patients with impaired renal clearance.
  • History of seizures: avoid or monitor closely due to increased seizure risk.
  • Hypersensitivity: discontinue if signs of allergic reaction appear.
  • Concomitant antibiotics: evaluate for additive toxicity, especially nephrotoxic agents.
  • Pregnancy and lactation: use only if benefits outweigh potential risks, as safety data are limited.
  • Store at 2‑8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Doripenem can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Valproic acid: may reduce plasma levels of valproate, risking seizure breakthrough.
  • Probenecid: can increase doripenem concentrations, raising toxicity risk.
  • Carbapenem‑resistant β‑lactamase inhibitors: may antagonize antibacterial activity.

Moderate Interactions (Monitor Closely)

  • Aminoglycosides: combined nephrotoxicity potential; monitor renal function.
  • Loop diuretics: may enhance ototoxicity when used together.
  • Anticoagulants (warfarin): possible alteration of INR; check coagulation parameters.

Frequently Asked Questions

Dormax 500Mg Inj contains doripenem, a carbapenem antibiotic indicated for the treatment of complicated intra‑abdominal infections, complicated urinary tract infections, and hospital‑acquired (nosocomial) pneumonia in adult patients requiring intravenous therapy.

Doripenem exerts its antibacterial effect by binding to penicillin‑binding proteins, which blocks the final step of peptidoglycan cross‑linking in bacterial cell walls. This inhibition leads to loss of cell wall integrity and bacterial cell death, and the molecule is resistant to many β‑lactamases.

The specific dose of Dormax 500Mg Inj is determined by the prescribing clinician based on the infection type, severity, patient weight, renal function, and other clinical factors. No fixed regimen is provided here; dosing must follow the prescriber’s order.

Safety data for doripenem in pregnancy and lactation are limited, and the pregnancy category is listed as unknown. It should only be used when the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Dormax 500Mg Inj. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Dormax (doripenem) shares the broad‑spectrum activity of carbapenems such as imipenem and meropenem but has a slightly lower propensity for inducing seizures and offers enhanced stability against certain β‑lactamases. Choice among carbapenems depends on local resistance patterns, patient renal function, and specific safety considerations.

Dormax 500Mg Inj must be stored at 2‑8 °C in a refrigerator, protected from light. The vial should not be frozen or shaken. If the product is removed from refrigeration for a short period, it should be used promptly and returned to the controlled temperature environment as soon as possible.

Dormax is supplied as a sterile injection solution for intravenous infusion. It is typically reconstituted with a compatible diluent and administered over a prescribed period, often 30 minutes to 1 hour, under aseptic conditions by qualified healthcare personnel.

The most serious adverse events associated with Doripenem include seizures, especially in patients with renal impairment or pre‑existing CNS disorders, severe hypersensitivity reactions such as anaphylaxis, and Clostridioides difficile‑associated colitis, which can be life‑threatening.

Dormax should be avoided in patients with a known hypersensitivity to doripenem, other carbapenems, or any component of the formulation. Caution is also required for individuals with severe renal impairment who have not had dose adjustment, and for those with a history of seizures unless benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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