Product image of Mardozia Pf (Χωρίσ Συντηρητικό) (Dorzolamide, Timolol) supplied by GNH India

Mardozia Pf (Χωρίσ Συντηρητικό)

Active Ingredient:
Dorzolamide, Timolol
Origin:
EU

Mardozia Pf (Χωρίσ Συντηρητικό) (Dorzolamide, Timolol)

Dorzolamide and Timolol, the active ingredients in Mardozia Pf, are a carbonic anhydrase inhibitor and a non‑selective beta‑blocker presented as eye‑drop solution for ocular use. They are employed to lower intra‑ocular pressure in adults with open‑angle glaucoma or ocular hypertension.

GNH India supplies Mardozia Pf as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory documentation for import. Customers receive batch‑specific certificates of analysis and can request temperature‑controlled shipping where required.

Manufacturer / TM Owner

Pharmathen S.A.

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Indications & Clinical Uses

Mardozia Pf combines dorzolamide and timolol to manage conditions that involve elevated intra‑ocular pressure.

  • Open‑angle glaucoma: reduces intra‑ocular pressure to slow optic nerve damage.
  • Ocular hypertension: lowers intra‑ocular pressure to prevent progression to glaucoma.
  • Secondary glaucoma (e.g., pseudoexfoliative): helps control pressure and protect visual function.

How It Works

  • Dorzolamide inhibits carbonic anhydrase in the ciliary body, decreasing aqueous humor production, while timolol blocks β‑adrenergic receptors, also reducing aqueous humor formation. The combined effect results in a significant reduction of intra‑ocular pressure, helping to preserve optic nerve health.

Side Effects

Mardozia Pf may cause ocular and systemic adverse reactions.

Common Side Effects

  • Eye irritation or burning sensation.
  • Transient blurred vision.
  • Bitter taste after administration.
  • Headache.
  • Dry eye or reduced tear production.
  • Mild ocular discomfort.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angio‑edema, rash).
  • Marked bradycardia or heart block.
  • Bronchospasm, especially in asthmatic patients.
  • Systemic hypotension.
  • Corneal edema or persistent visual loss.
  • Acute intra‑ocular inflammation.

Precautions & Warnings

Before using Mardozia Pf, consider the following safety measures.

  • Cardiac assessment: avoid in patients with severe bradycardia or heart block.
  • Respiratory status: use with caution in asthma or COPD.
  • Sulfonamide allergy: dorzolamide contains a sulfonamide moiety; contraindicated in known hypersensitivity.
  • Concomitant beta‑blocker eye drops: avoid combined use to prevent excessive IOP reduction.
  • Pregnancy and lactation: prescribe only if clearly needed; safety data are limited.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Mardozia Pf can interact with several systemic and ocular agents.

Major Interactions (Avoid)

  • Systemic beta‑blockers: additive bradycardia and hypotension.
  • Non‑selective beta‑blocker inhalers: increased risk of bronchospasm.
  • Other carbonic anhydrase inhibitors: excessive reduction of aqueous humor.
  • Topical adrenergic agonists: antagonistic effect on intra‑ocular pressure reduction.

Moderate Interactions (Monitor Closely)

  • Anticholinergic eye drops: may alter pupil dynamics.
  • Diuretics: potential electrolyte disturbances.
  • CYP2D6 inhibitors: may increase timolol plasma concentrations.

Frequently Asked Questions

Mardozia Pf is an ophthalmic solution that contains dorzolamide and timolol. It is prescribed to lower intra‑ocular pressure in adults with open‑angle glaucoma or ocular hypertension, helping to prevent optic nerve damage and preserve vision.

Dorzolamide inhibits the enzyme carbonic anhydrase in the ciliary body of the eye, which reduces the production of aqueous humor. This decrease in fluid formation contributes to lower intra‑ocular pressure, a key factor in managing glaucoma.

The dosing regimen for Mardozia Pf is determined by the prescribing ophthalmologist based on the patient’s condition and response. Typically, one or two drops are instilled in each affected eye once or twice daily, but the exact schedule should follow the prescriber’s instructions.

Safety data for Mardozia Pf in pregnancy and lactation are limited. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by the treating physician.

To order Mardozia Pf, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Mardozia Pf combines a carbonic anhydrase inhibitor (dorzolamide) with a non‑selective beta‑blocker (timolol), offering dual mechanisms to reduce aqueous humor production. Compared with single‑agent drops, this combination can achieve greater intra‑ocular pressure reduction, potentially reducing the need for multiple separate medications.

Store Mardozia Pf at room temperature, below 25 °C. Keep the bottle in its original packaging, protect it from direct light and moisture, and ensure the cap is tightly closed to maintain sterility.

Mardozia Pf is applied as eye drops. The patient should wash hands, tilt the head back, pull down the lower eyelid to create a pocket, and instill the prescribed number of drops without touching the tip of the bottle to the eye or any surface.

Serious risks include severe allergic reactions, marked bradycardia or heart block, bronchospasm in susceptible individuals, and systemic hypotension. Patients should be instructed to seek immediate medical attention if they experience symptoms such as difficulty breathing, rapid heartbeat, or swelling of the face or throat.

Mardozia Pf should be avoided in patients with known hypersensitivity to dorzolamide, timolol, sulfonamides, or any component of the formulation. It is also contraindicated in individuals with severe bradycardia, advanced heart block, uncontrolled asthma, or chronic obstructive pulmonary disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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