Product image of Doxazosin Cor 1 A Pharma (Doxazosin Mesilate) supplied by GNH India

Doxazosin Cor 1 A Pharma

Active Ingredient:
Doxazosin Mesilate
Origin:
EU

Doxazosin Cor 1 A Pharma (Doxazosin Mesilate)

Doxazosin Cor 1 A Pharma is an oral medication that contains the active ingredient Doxazosin Mesilate. It is supplied as a prescription tablet marketed in the European Union. Doxazosin belongs to the selective alpha‑1 adrenergic receptor antagonist class and is used to manage high blood pressure and symptoms of benign prostatic hyperplasia. It relaxes blood vessels and prostate smooth muscle, lowering resistance and easing urine flow.

Manufacturer / TM Owner

1 A Pharma Gmbh

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Indications & Clinical Uses

Doxazosin Cor 1 A Pharma is indicated for two primary therapeutic areas.

  • Hypertension (essential high blood pressure) – used as monotherapy or in combination to achieve target blood pressure.
  • Benign prostatic hyperplasia (BPH) – alleviates urinary obstruction symptoms such as hesitancy, weak stream, and nocturia.
  • Adjunctive treatment of renal artery stenosis‑related hypertension.
  • Off‑label use in certain cases of pheochromocytoma under specialist supervision.

Side Effects

Side‑effect profiles of Doxazosin Cor 1 A Pharma reflect its vasodilatory and smooth‑muscle‑relaxing actions.

Common

  • Dizziness or light‑headedness, especially when standing quickly.
  • Headache.
  • Fatigue or mild weakness.
  • Nasal congestion.
  • Peripheral edema.
  • Postural (orthostatic) hypotension.

Serious

  • Severe hypotension or syncope.
  • Tachycardia or arrhythmia.
  • Angioedema (swelling of face, lips, tongue).
  • Hepatic dysfunction (elevated liver enzymes).
  • Priapism (prolonged painful erection).

Precautions & Warnings

Before prescribing Doxazosin Cor 1 A Pharma, clinicians should evaluate several safety considerations.

  • History of orthostatic hypotension or volume depletion.
  • Severe hepatic impairment.
  • Concomitant use of other antihypertensives may increase risk of low blood pressure.
  • Known hypersensitivity to doxazosin or related quinazoline compounds.
  • Elderly patients may have an increased risk of falls due to blood‑pressure lowering effects.
  • Pregnancy and lactation status are unknown; use only if the potential benefit justifies the risk.

Avoid Interactions

Doxazosin can interact with other medicines that affect blood pressure or hepatic metabolism.

Avoid

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole).
  • Other alpha‑blockers or potent vasodilators (e.g., prazosin, nitroglycerin).

Use with caution

  • Diuretics, especially loop or thiazide types.
  • ACE inhibitors or angiotensin‑II receptor blockers.
  • Sildenafil and other PDE5 inhibitors.
  • Beta‑blockers.
  • Medications that may cause electrolyte disturbances.

Frequently Asked Questions

Doxazosin blocks peripheral alpha‑1 adrenergic receptors, causing vasodilation and reduced peripheral vascular resistance, and relaxes smooth muscle in the prostate and bladder neck.

Yes, it may be prescribed as monotherapy for hypertension, but clinicians often combine it with other antihypertensive agents to achieve target blood‑pressure goals.

Doxazosin improves urinary flow by relaxing prostate smooth muscle, helping to reduce symptoms such as hesitancy, weak stream, and nocturia in men with benign prostatic hyperplasia.

Common adverse effects include dizziness, headache, fatigue, nasal congestion, peripheral edema, and orthostatic hypotension.

Patients should avoid it if they are taking strong CYP3A4 inhibitors or other alpha‑blockers, as these combinations can cause excessive blood‑pressure lowering.

It is usually started at a low dose and taken once daily, preferably in the morning, with patients advised to rise slowly from sitting or lying positions.

Caution is advised in severe hepatic impairment because the drug is metabolized by the liver and exposure may be increased.

Co‑administration can cause additive blood‑pressure lowering effects; clinicians should use caution, monitor blood pressure, and adjust doses if necessary.

Blood pressure and heart rate should be checked regularly, especially during dose titration, and liver function tests may be considered in patients with hepatic risk factors.

Pregnancy category is unknown; the drug should be used only if the potential benefit justifies the potential risk to the fetus.

They should sit or lie down immediately, avoid standing quickly, and contact their healthcare provider to discuss possible dose adjustment.

Doxazosin does not have a direct effect on lipid metabolism; it is primarily an antihypertensive and BPH medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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