Product image of Endoxan 50mg (Cyclophosphamide IP) 50mg Tablet supplied by GNH India

Endoxan 50mg

Active Ingredient:
Cyclophosphamide IP
Form:
Tablet
Brand:
Endoxan
Origin:
India

Endoxan 50mg (Cyclophosphamide IP Tablet) 50mg

Cyclophosphamide, the active ingredient in Endoxan 50mg, is an alkylating agent presented as a 50mg tablet for oral use. It is used in the treatment of various cancers and certain autoimmune diseases in adults and children. GNH India supplies Endoxan 50mg as a licensed, GDP-compliant international pharmaceutical supplier serving oncology centres worldwide.

Endoxan 50mg is a potent chemotherapy medication used to manage multiple types of cancer, including lymphomas, leukemias, and breast cancer. It belongs to the class of alkylating agents and works by destroying cancer cells and preventing them from dividing.

Strength

50mg

Pack Size

100's

Storage

15-25°

Manufacturer / TM Owner

Cadila Healthcare Limited

1
Pack/s
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Indications & Clinical Uses

Endoxan 50mg is used in the treatment of various malignant and autoimmune conditions. It acts by inhibiting the growth and multiplication of cancer cells and suppressing the immune system in autoimmune diseases.

  • Lymphomas: Treats various types of lymphomas by inhibiting the growth of abnormal lymphocytes.
  • Leukemias: Effective in managing different types of leukemia by targeting rapidly dividing cancer cells in the blood.
  • Breast cancer: Helps interfere with cancer cell replication and is used in combination with other treatments.
  • Ovarian cancer: Used in the treatment of ovarian cancer to slow down or stop the growth of cancer cells.
  • Autoimmune diseases: Used in conditions like systemic lupus erythematosus and vasculitis to suppress the immune system and reduce inflammation.

How It Works

  • Endoxan 50mg works by causing intra- and inter-strand crosslinks between DNA bases, leading to breaks in the DNA strand. This action induces apoptosis, resulting in the death of abnormal DNA-containing cancer cells. It is a prodrug that is converted in the body to active metabolites, which act at any stage of the cell cycle to prevent cell division and reduce DNA synthesis.

Side Effects

Endoxan 50mg may cause various side effects, ranging from common to serious.

Common Side Effects

  • Nausea and vomiting
  • Hair loss (alopecia)
  • Fatigue or weakness
  • Loss of appetite
  • Diarrhea
  • Skin pigmentation
  • Skin rash
  • Fever
  • Neutropenia

Serious or Rare Side Effects

  • Secondary cancers (long-term risk)
  • Heart problems (chest pain, irregular heartbeat)
  • Blood in urine
  • Unusual bleeding or bruising
  • Signs of infection (fever, chills, persistent sore throat)
  • Severe allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)

Precautions & Warnings

Endoxan 50mg should be used with caution and under the supervision of a healthcare professional. It is contraindicated in patients with a history of severe myelosuppression and urinary outflow obstruction. It should not be taken if you are allergic to cyclophosphamide.

  • Allergy: Do not take this medicine if you are allergic to cyclophosphamide.
  • Myelosuppression: Use with caution in patients with a history of severe myelosuppression.
  • Urinary outflow obstruction: Contraindicated in patients with urinary outflow obstruction.
  • Pregnancy: Should be avoided during pregnancy due to potential harm to the fetus.
  • Breastfeeding: Contraindicated during breastfeeding.
  • Store below 25°C: Keep in the original pack, protect from moisture.

Avoid Interactions

Endoxan 50mg may interact with other medications, which can affect its efficacy or increase the risk of side effects. It is important to inform your healthcare provider about all medications you are taking.

Major Interactions (Avoid)

  • Suphinpyrazone: Increases the risk of myelosuppression.
  • Phenylbutazone: Increases the risk of bone marrow suppression.
  • Cimetidine: Increases the risk of bone marrow suppression.
  • Allopurinol: Increases the risk of bone marrow suppression.
  • Vaccines: Increases the risk of infection due to immunosuppression.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: Increases the risk of bleeding.
  • Corticosteroids: Increases the risk of infection.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs): Increases the risk of gastrointestinal bleeding.
  • Antidiabetic agents: May alter blood sugar control.

Frequently Asked Questions

Endoxan 50mg is used in the treatment of various cancers, including lymphomas, leukemias, and breast cancer. It is also used to manage certain autoimmune diseases such as systemic lupus erythematosus and vasculitis. The medication works by inhibiting the growth and multiplication of cancer cells and suppressing the immune system in autoimmune conditions.

Cyclophosphamide, the active ingredient in Endoxan 50mg, is an alkylating agent that causes intra- and inter-strand crosslinks between DNA bases. This action leads to breaks in the DNA strand, inducing apoptosis and resulting in the death of abnormal DNA-containing cancer cells. It is a prodrug that is converted in the body to active metabolites, which act at any stage of the cell cycle to prevent cell division and reduce DNA synthesis.

The dose of Endoxan 50mg is determined by a healthcare professional based on the patient's condition, response to treatment, and other factors. It is important to follow the prescribed dosage and instructions provided by your doctor. Do not adjust the dose without consulting your healthcare provider.

Endoxan 50mg should be avoided during pregnancy due to the potential harm it can cause to the fetus. It is also contraindicated during breastfeeding. Women of childbearing age should use effective contraception during treatment with Endoxan 50mg. Always consult your healthcare provider for personalized advice.

To order Endoxan 50mg from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will reply with pricing, availability, shipping, and the import paperwork.

Endoxan 50mg is an alkylating agent that is commonly used in the treatment of various cancers. It works by causing DNA damage, leading to the death of cancer cells. Compared to other chemotherapy drugs, Endoxan 50mg has a broad spectrum of activity and is often used in combination with other treatments. The choice of chemotherapy drug depends on the type and stage of cancer, as well as the patient's overall health.

Endoxan 50mg should be stored below 25°C, in the original pack, and protected from moisture. It is important to handle the medication with care, following the instructions provided by your healthcare provider. Keep the medication out of reach of children and pets, and dispose of it properly to avoid any potential harm.

Endoxan 50mg is taken orally with food. You should not chew, cut, or crush the tablet. The dose is determined by a healthcare professional based on the patient's condition and response to treatment. It is important to follow the prescribed dosage and instructions provided by your doctor.

The most serious risks associated with Endoxan 50mg include secondary cancers, heart problems, blood in urine, unusual bleeding or bruising, signs of infection, and severe allergic reactions. It is important to monitor for these risks and report any unusual symptoms to your healthcare provider immediately.

Endoxan 50mg should not be used by patients with a history of severe myelosuppression, urinary outflow obstruction, or those who are allergic to cyclophosphamide. It should also be avoided during pregnancy and breastfeeding. Always consult your healthcare provider to determine if Endoxan 50mg is suitable for you.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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