Lidocaína Adrenalina Labesfal (Epinephrine Bitartrate, Lidocaine Hydrochloride)

Lidocaína Adrenalina Labesfal, a combination local anesthetic with vasoconstrictor, is indicated for procedures requiring soft‑tissue anesthesia.

• Minor surgical procedures: provides localized numbness to facilitate incision, excision and suturing.
• Dental procedures: enables painless soft‑tissue work such as extractions, root canal access and periodontal surgery.
• Dermatologic or cosmetic interventions: allows infiltration anesthesia for skin lesion removal, laser therapy or minor cosmetic surgery.

• Lidocaine blocks voltage‑gated sodium channels in neuronal membranes, preventing initiation and propagation of nerve impulses and thereby producing loss of sensation. Epinephrine stimulates α‑adrenergic receptors on vascular smooth muscle, causing vasoconstriction that limits systemic absorption of lidocaine, prolongs its local effect and reduces bleeding at the injection site.

Adverse reactions to Lidocaína Adrenalina Labesfal may vary in frequency and severity.

Common Side Effects

• Tingling or numbness at the injection site
• Mild swelling or erythema
• Transient dizziness
• Headache
• Nausea
• Elevated heart rate (palpitations)

Serious or Rare Side Effects

• Severe allergic reaction (anaphylaxis)
• Cardiac arrhythmias
• Seizures
• Methemoglobinemia
• Persistent hypotension
• Tissue necrosis at the injection site

When using Lidocaína Adrenalina Labesfal, clinicians should observe several safety measures.

• Assess patient allergy: verify no known hypersensitivity to lidocaine, epinephrine or amide anesthetics.
• Review cardiovascular status: avoid in patients with uncontrolled hypertension, arrhythmias, or recent myocardial infarction.
• Limit dosage: adhere to the recommended maximum dose based on patient weight and injection site.
• Use caution with MAO inhibitors or tricyclic antidepressants: these may increase systemic toxicity.
• Monitor for signs of systemic toxicity: watch for CNS or cardiovascular symptoms.
• Store at room temperature: keep in the original container, protect from light and moisture.

Lidocaína Adrenalina Labesfal can interact with several drug classes; clinicians should review patient medication lists.

Major Interactions (Avoid)

• MAO inhibitors: increased risk of hypertensive crisis with epinephrine.
• β‑blockers: may potentiate epinephrine‑induced tachycardia.
• Class I antiarrhythmics (e.g., quinidine): can exacerbate lidocaine toxicity.
• Tricyclic antidepressants: raise lidocaine plasma levels.
• Non‑selective α‑adrenergic antagonists: reduce vasoconstrictive effect of epinephrine.

Moderate Interactions (Monitor Closely)

• Antihistamines: may mask early signs of allergic reaction.
• Diuretics: alter plasma volume affecting drug distribution.
• CYP3A4 inhibitors (e.g., erythromycin): modestly increase lidocaine levels.
• Sympathomimetic drugs (e.g., phenylephrine): additive vasoconstriction.
• Alcohol: may enhance central nervous system depression.