Epinephrine (Epinephrine)

Trade Name : Epinephrine

Medical Purchasing Solutions, LLC

INJECTION, SOLUTION, CONCENTRATE

Strength 1 mg/mL

EPINEPHRINE Adrenergic alpha-Agonists [MoA],Adrenergic beta-Agonists [MoA],alpha-Adrenergic Agonist [EPC],beta-Adrenergic Agonist [EPC],Catecholamine [EPC],Catecholamines [CS]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Epinephrine (Epinephrine) which is also known as Epinephrine and Manufactured by Medical Purchasing Solutions, LLC. It is available in strength of 1 mg/mL per ml. Read more

Epinephrine (Epinephrine) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • Warnings and Precautions (n n n )u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0 u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0 u00a05/2016n nn
  • Epinephrine is a non-selective alpha and beta adrenergic agonist indicated:
  • To increase mean arterial blood pressure in adult patients with hypotension associated with septic shock. (n n n )n n n
  • For emergency treatment of allergic reactions (Type 1), including anaphylaxis. (n n n )n n n
  • For induction and maintenance of mydriasis during intraocular surgery. (n n n )n n n
  • u2022 n n n n
  • u2022 n n n n
  • u2022 n n n n
  • Injection solution: 1 mg/1 mL epinephrine as a sterile solution in a 2 mL single-use clear glass ampule, marked Epinephrine Injection USP, 1 mg/mL.
  • Injection solution: 1 mg/1 mL, 2 mL single-use ampule. (n n n )n n n
  • None.
  • None. (n n n )n nn
  • No data
  • Monitor patient for acute severe hypertension. (n n n )n n n
  • Avoid extravasation into tissues, which can cause local necrosis. (n n n )n n n
  • Do not inject into buttocks, digits, hands, or feet. (n n n )n n n
  • Potential for pulmonary edema, which may be fatal. (n n n )n n n
  • May constrict renal blood vessels and decrease urine formation. (n n n )n n n
  • May induce potentially serious cardiac arrhythmias or aggravate angina pectoris, particularly in patients with underlying heart disease. (n n n )n n n
  • Rare cases of serious skin and soft tissue infections have been reported following epinephrine injection. Advise patients to seek medical care if they develop signs or symptoms of infection. (n n n )n n n
  • Patients with hyperthyroidism, Parkinson's disease, diabetes, and pheochromocytoma are at greater risk of having adverse reactions when used intravenously, intramuscularly, or subcutaneously. (n n n )n n n
  • Most common adverse reactions to systemically administered epinephrine are headache; anxiety; apprehensiveness; restlessness; tremor; weakness; dizziness; sweating; palpitations; pallor; peripheral coldness; nausea/vomiting; and/or respiratory difficulties. Arrhythmias, including fatal ventricular fibrillation, rapid rises in blood pressure producing cerebral hemorrhage, and angina have occurred. (n n n ,n n n )n nn
  • Drugs antagonizing pressor effects of epinephrine
  • Drugs potentiating pressor effects of epinephrine
  • Drugs potentiating arrhythmogenic effects of epinephrine.n- [see Warnings and Precautions n n n and Adverse Reactions n n n ].n n n
  • Drugs potentiating hypokalemic effects of epinephrine
  • Epinephrine should not be used to counteract circulatory collapse or hypotension caused by phenothiazines, as a reversal of the pressor effects of epinephrine may result in further lowering of blood pressure.
  • Epinephrine may antagonize the neuronal blockade produced by guanethidine resulting in decreased antihypertensive effect and requiring increased dosage of the latter.
  • Drugs that counter the pressor effects of epinephrine include alpha blockers, vasodilators such as nitrates, diuretics, antihypertensives and ergot alkaloids. (n n n )n n n
  • Drugs that potentiate the effects of epinephrine include sympathomimetics, beta blockers, tricyclic antidepressants, MAO inhibitors, COMT inhibitors, clonidine, doxapram, oxytocin, levothyroxine sodium, and certain antihistamines. (n n n )n n n
  • Drugs that increase the arrhythmogenic potential of epinephrine include beta blockers, cyclopropane and halogenated hydrocarbon anesthetics, quinidine, antihistamines, exogenous thyroid hormones, diuretics, and cardiac glycosides. Observe for development of cardiac arrhythmias. (n n n )n n n
  • Potassium-depleting drugs, including corticosteroids, diuretics, and theophylline, potentiate the hypokalemic effects of epinephrine. (n n n )n n n
  • No data
  • Pregnancy: Epinephrine may lead to fetal anoxia, spontaneous abortion or both. (n n n )n n n
  • Elderly patients and pregnant women may be at greater risk of developing adverse reactions when epinephrine is administered parenterally. (n n n ,n n n )n n n
  • Overdosage of epinephrine may produce extremely elevated arterial pressure, which may result in cerebrovascular hemorrhage, particularly in elderly patients. Overdosage may also result in pulmonary edema because of peripheral vascular constriction together with cardiac stimulation. Epinephrine overdosage may also cause transient bradycardia followed by tachycardia and these may be accompanied by potentially fatal cardiac arrhythmias. Premature ventricular contractions may appear within one minute after injection and may be followed by multifocal ventricular tachycardia (prefibrillation rhythm). Subsidence of the ventricular effects may be followed by atrial tachycardia and occasionally by atrioventricular block. Myocardial ischemia and infarction, cardiomyopathy, extreme pallor and coldness of the skin, metabolic acidosis due to elevated blood lactic acid levels, and renal insufficiency and failure have also been reported.
  • Epinephrine is rapidly inactivated in the body and treatment following overdose is primarily supportive. Treatment of pulmonary edema consists of a rapidly acting alpha-adrenergic blocking drug (such as phentolamine mesylate) and respiratory support. Treatment of arrhythmias consists of administration of a beta-adrenergic blocking drug (such as propranolol). If necessary, pressor effects may be counteracted by rapidly acting vasodilators (such as nitrites) or alpha-adrenergic blocking drugs. If prolonged hypotension follows such measures, it may be necessary to administer another pressor drug.
  • Epinephrine Injection USP, 1 mg/mL is supplied as a sterile aqueous solution with a pH range of 2.2-5.0, that is colorless and nonpyrogenic. Each milliliter contains 1 mg epinephrine, sodium chloride 9 mg (for isotonicity), hydrochloric acid for pH adjustment, and water for injection, USP, qs. Contains no preservatives or sulfites.
  • Solution must be diluted prior to intravenous or ocular use.
  • Epinephrine, USP is a sympathomimetic catecholamine (adrenergic agent) designated chemically as 4-[1-hydroxy-2 (methylamino) ethyl]-1,2 benzenediol, a white, microcrystalline powder. It has the following structural formula:
  • The molecular weight of epinephrine is 183.2.
  • Epinephrine solution deteriorates rapidly on exposure to air or light, turning pink from oxidation to adrenochrome and brown from the formation of melanin.
  • No data
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  • Epinephrine Injection USP, 1 mg/mL is a sterile solution containing 1 mg/1 mL epinephrine in a 2 mL clear glass ampule. Supplied in a box of 10 single-use ampules (NDC 54288-103-10).
  • Epinephrine is light sensitive. Protect from light until ready to use.
  • Do not refrigerate. Protect from freezing.
  • Store at room temperature, between 20u00b0 to 25u00b0C (68u00b0 to 77u00b0F). (See USP Controlled Room Temperature.) Protect from alkalis and oxidizing agents.
  • Inspect visually for particulate matter and discoloration prior to administration. Do not use the solution if it is colored or cloudy, or if it contains particulate matter.
  • Advise patients or their caregivers about common adverse reactions associated with the use of epinephrine, including an increase in heart rate, the sensation of a more forceful heartbeat, palpitations, sweating, nausea and vomiting, difficulty breathing, pallor, dizziness, weakness or shakiness, headache, apprehension, nervousness, or anxiety. These symptoms and signs usually subside rapidly, especially with rest, quiet and recumbent positioning.
  • Warn patients with a good response to initial treatment about the possibility of recurrence of anaphylaxis symptoms and instruct patients to obtain medical attention if symptoms return.
  • Advise patients with diabetes that they may develop increased blood glucose levels following epinephrine administration.
  • Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis caused by Clostridia (gas gangrene), have been reported at the injection site following epinephrine injection for anaphylaxis. Advise patients to seek medical care if they develop signs or symptoms of infection, such as persistent redness, warmth, swelling, or tenderness, at the epinephrine injection siten n n .n nn
  • Revised: February 2017 u00a0 u00a0 L103I u00a0 u00a0 u00a0R-1704
  • Manufactured for:
  • BPI Labs, LLC, Freehold, NJ 07728 USA
  • Manufactured by:
  • Sintetica SAn n n Via Penate 5n n n 6850 Mendrisio, Switzerland n nn
  • Epinephrine Injection, USPn- 1 mg/mL
  • NDC 71872-7117-1
  • For Intravenous Infusion, Intramuscular and Subcutaneous Use, and Intraocular Use
  • Usual Dose: See insert labeling
  • Each mL contains:n n n1 mg Epinephrine,n n nSodium Chloride 9 mg, Water for Injection, USPn n npH adjusted with Hydrochloric Acid.n
  • WARNING:
  • 10 Single-Use Ampules x 1mL
  • CONTAINS NO SULFITES OR PRESERVATIVES

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