Product image of Lidocaína/Adrenalina Aguettant (Epinephrine, Lidocaine Hydrochloride) supplied by GNH India

Lidocaína/Adrenalina Aguettant

Active Ingredient:
Epinephrine, Lidocaine Hydrochloride
Origin:
EU

Lidocaína/Adrenalina Aguettant (Epinephrine, Lidocaine Hydrochloride)

Lidocaine hydrochloride, the active ingredient in Lidocaína/Adrenalina Aguettant, is a local anesthetic combination presented as a sterile injectable solution for epidural, infiltration and perineural use. It provides local anesthesia for surgical procedures and related interventions.
GNH India supplies Lidocaína/Adrenalina Aguettant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

Lidocaína/Adrenalina Aguettant is a local anesthetic combination used in procedures that require regional nerve blockade or surface anesthesia.

  • Surgical procedures: provides rapid onset and prolonged local anesthesia for incision and excision.
  • Epidural analgesia: extends pain relief during labor or postoperative periods.
  • Infiltration anesthesia: numbs tissue directly at the surgical site.
  • Perineural (nerve block) anesthesia: blocks transmission along targeted nerves for limb or extremity surgery.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels in neuronal membranes, preventing depolarisation and impulse conduction. Epinephrine activates α‑adrenergic receptors, causing vasoconstriction that limits systemic absorption of lidocaine, thereby prolonging its local anesthetic effect and reducing bleeding at the injection site.

Side Effects

Adverse reactions may occur following administration of the lidocaine/epinephrine combination.

Common Side Effects

  • Pain or irritation at the injection site
  • Transient tachycardia
  • Mild hypertension
  • Nausea or vomiting
  • Dizziness or light‑headedness
  • Local swelling or erythema

Serious or Rare Side Effects

  • Severe arrhythmias or cardiac arrest
  • Myocardial infarction
  • Anaphylactic or severe allergic reaction
  • Seizures or central nervous system toxicity
  • Profound hypotension
  • Respiratory depression

Precautions & Warnings

Before using Lidocaína/Adrenalina Aguettant, clinicians should consider several safety measures.

  • Cardiovascular assessment: evaluate heart rate, blood pressure, and arrhythmia risk.
  • Hypertension caution: use lower concentrations in patients with uncontrolled high blood pressure.
  • Hypersensitivity: avoid in individuals with known allergy to lidocaine, epinephrine, or related compounds.
  • Systemic toxicity monitoring: observe for signs of CNS or cardiac toxicity during and after injection.
  • Hepatic impairment: adjust dose or monitor closely in patients with reduced liver function.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Lidocaína/Adrenalina Aguettant may interact with other medications, requiring careful review.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs)
  • Non‑selective beta‑blockers
  • Tricyclic antidepressants
  • Other local anesthetics administered concurrently
  • Sympathomimetic agents (e.g., phenylephrine)

Moderate Interactions (Monitor Closely)

  • Cimetidine or other H2‑blockers
  • Calcium channel blockers
  • Diuretics that affect electrolyte balance
  • Anti‑arrhythmic drugs
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs)

Frequently Asked Questions

Lidocaína/Adrenalina Aguettant is a combination of lidocaine and epinephrine used to provide local anesthesia for surgical procedures, epidural analgesia, infiltration anesthesia, and perineural nerve blocks. The epinephrine component prolongs the anesthetic effect by constricting blood vessels at the injection site.

Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, which stops the initiation and propagation of nerve impulses. This interruption of electrical signaling produces a reversible loss of sensation in the targeted area.

The specific dose and concentration are determined by the prescribing clinician based on the type of procedure, patient weight, and clinical setting. Healthcare professionals calculate the appropriate amount to achieve effective anesthesia while minimizing systemic exposure.

Safety data for use in pregnancy or lactation are limited. The product should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with lidocaine without epinephrine, the combination offers a longer duration of anesthesia and reduced systemic absorption, which can lower the risk of toxicity. The vasoconstrictive action of epinephrine also helps control bleeding at the injection site.

Lidocaína/Adrenalina Aguettant should be stored at ambient temperature, below 25 °C, in its original sealed container. Protect it from moisture, direct sunlight and extreme temperatures to maintain sterility and potency.

The product is supplied as a sterile injectable solution and is administered by a qualified healthcare professional via epidural, infiltration or perineural injection techniques, depending on the clinical indication.

Serious risks include severe cardiac arrhythmias, myocardial infarction, anaphylaxis, seizures, profound hypotension and respiratory depression. Immediate medical attention is required if any of these events occur.

Patients with known hypersensitivity to lidocaine, epinephrine, or any component of the formulation should avoid this product. It is also contraindicated in individuals with uncontrolled hypertension, certain cardiac conditions, or those taking interacting medications listed under major interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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