Product image of Lidocaína/Adrenalina Aguettant (Epinephrine, Lidocaine Hydrochloride) supplied by GNH India

Lidocaína/Adrenalina Aguettant

Active Ingredient:
Epinephrine, Lidocaine Hydrochloride
Origin:
EU

Lidocaína/Adrenalina Aguettant (Epinephrine, Lidocaine Hydrochloride)

Lidocaine hydrochloride and epinephrine, the active ingredient in Lidocaína/Adrenalina Aguettant, is a local anesthetic with vasoconstrictor presented as a solution for epidural, infiltration and perineural use. It provides rapid, localized anesthesia for surgical procedures and nerve‑block techniques in adult patients.

GNH India supplies Lidocaína/Adrenalina Aguettant as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

Lidocaína/Adrenalina Aguettant is a combination local anesthetic used in procedures that require rapid, site‑specific nerve blockade.

  • Surgical procedures: delivers reliable local anesthesia for incision and minor surgery.
  • Epidural anesthesia: extends analgesia for obstetric and postoperative pain control.
  • Perineural nerve block: facilitates targeted nerve blockade for limb surgeries.
  • Infiltration anesthesia: provides localized numbness for dermatologic and minor invasive procedures.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing depolarisation and impulse transmission. Epinephrine activates α‑ and β‑adrenergic receptors, causing vasoconstriction that reduces local blood flow, prolongs lidocaine’s effect, and limits systemic absorption.

Side Effects

Adverse reactions may occur following administration of lidocaine‑epinephrine mixtures.

Common Side Effects

  • Injection site pain: mild discomfort at the site of administration.
  • Transient dizziness: brief light‑headedness during onset.
  • Nausea: occasional upset stomach.
  • Headache: mild to moderate intensity.
  • Increased heart rate: mild tachycardia.
  • Sweating: localized diaphoresis.

Serious or Rare Side Effects

  • Cardiac arrhythmias: irregular heart rhythms, especially with high epinephrine levels.
  • Severe hypertension: sudden rise in blood pressure.
  • Seizures: central nervous system excitation from lidocaine toxicity.
  • Allergic reactions: rash, urticaria, or anaphylaxis.
  • Cardiac arrest: rare but life‑threatening.
  • Methemoglobinemia: abnormal hemoglobin affecting oxygen delivery.

Precautions & Warnings

Before using Lidocaína/Adrenalina Aguettant, consider the following safety measures.

  • Allergy assessment: verify no hypersensitivity to lidocaine or epinephrine.
  • Cardiovascular status: use cautiously in patients with uncontrolled hypertension or arrhythmias.
  • Pregnancy: safety not established; weigh benefits against potential risks.
  • Concomitant MAO inhibitors: avoid due to risk of hypertensive crisis.
  • Dosage limits: do not exceed the recommended maximum lidocaine dose.
  • Store below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Lidocaína/Adrenalina Aguettant may interact with other medicines; monitor patients accordingly.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors: risk of severe hypertension.
  • Non‑selective β‑blockers: may potentiate epinephrine‑induced cardiovascular effects.
  • Tricyclic antidepressants: increase risk of arrhythmias.

Moderate Interactions (Monitor Closely)

  • Other local anesthetics: cumulative lidocaine exposure.
  • Sympathomimetic drugs: additive vasoconstrictive effects.
  • CYP2D6 inhibitors (e.g., fluoxetine): may slow lidocaine metabolism, raising plasma levels.

Frequently Asked Questions

Lidocaína/Adrenalina Aguettant is a combination of lidocaine and epinephrine used to provide local anesthesia for surgical procedures, epidural anesthesia, perineural nerve blocks, and infiltration anesthesia. The epinephrine component prolongs the anesthetic effect and reduces systemic absorption.

Lidocaine blocks voltage‑gated sodium channels, stopping nerve impulse transmission and producing numbness. Epinephrine stimulates α‑ and β‑adrenergic receptors, causing vasoconstriction that limits blood flow at the injection site, thereby extending lidocaine’s duration and decreasing systemic exposure.

The specific dose and concentration are determined by the prescribing clinician based on the procedure, patient characteristics, and maximum allowable lidocaine limits. Healthcare professionals calculate the appropriate volume to achieve effective anesthesia while staying within safety guidelines.

Safety data for Lidocaína/Adrenalina Aguettant in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Compared with plain lidocaine, the addition of epinephrine provides longer‑lasting anesthesia and reduced systemic absorption, which can lower the risk of toxicity. It is similar to other lidocaine‑epinephrine formulations but may differ in concentration, packaging and regulatory status.

Store the product below 25 °C in its original container, protecting it from moisture and direct light. Do not freeze. Ensure the vial or ampoule is kept sealed until use and handle with aseptic technique to maintain sterility.

The solution is administered by a qualified healthcare professional via injection for epidural, infiltration or perineural techniques. The route (epidural, infiltration, perineural) is selected according to the clinical procedure, and the volume injected is calculated by the prescriber.

Serious adverse events include cardiac arrhythmias, severe hypertension, seizures, allergic reactions such as anaphylaxis, and, rarely, cardiac arrest or methemoglobinemia. Immediate medical attention is required if any of these symptoms develop after administration.

Patients with known hypersensitivity to lidocaine, epinephrine, or any component of the formulation should avoid this product. It is also contraindicated in individuals with uncontrolled hypertension, certain cardiac arrhythmias, or those taking non‑selective MAO inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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