Product image of Lidocaína + Adrenalina Normogen (Epinephrine, Lidocaine Hydrochloride) supplied by GNH India

Lidocaína + Adrenalina Normogen

Active Ingredient:
Epinephrine, Lidocaine Hydrochloride
Origin:
EU

Lidocaína + Adrenalina Normogen (Epinephrine, Lidocaine Hydrochloride)

Lidocaine hydrochloride, the active ingredient in Lidocaína + Adrenalina Normogen, is a local anesthetic with vasoconstrictor presented as an injectable solution for infiltration and perineural use. It provides local anesthesia for surgical procedures and dental work in adult patients.

GNH India supplies Lidocaína + Adrenalina Normogen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratórios Normon, S.A.

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Indications & Clinical Uses

Lidocaine combined with epinephrine is used for local anesthesia in procedures requiring nerve block or tissue infiltration.

  • Local infiltration anesthesia: provides rapid onset numbness for minor surgical or dental procedures.
  • Perineural (nerve block) anesthesia: prolongs analgesia during regional nerve block techniques.
  • Minor dermatologic procedures: facilitates painless excision or biopsy of skin lesions.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels in neuronal membranes, preventing depolarisation and nerve impulse conduction. Epinephrine stimulates α‑ and β‑adrenergic receptors, causing local vasoconstriction that reduces systemic absorption of lidocaine and extends its anesthetic duration.

Side Effects

Adverse reactions may occur after administration of lidocaine/epinephrine.

Common Side Effects

  • Transient burning or stinging at the injection site
  • Mild dizziness or light‑headedness
  • Nausea or mild gastrointestinal upset
  • Tachycardia or palpitations

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Cardiac arrhythmias, including ventricular tachycardia
  • Seizures, especially with high plasma lidocaine levels
  • Methemoglobinemia, a rare blood disorder

Precautions & Warnings

When using lidocaine with epinephrine, consider the following safety measures.

  • Allergy assessment: verify no known hypersensitivity to lidocaine or epinephrine.
  • Cardiovascular status: use cautiously in patients with uncontrolled hypertension or arrhythmias.
  • Pregnancy: limited data; weigh potential benefits against risks.
  • Pediatric use: dose adjustment required; monitor closely.
  • Drug interactions: avoid concurrent MAO inhibitors that may potentiate epinephrine effects.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Lidocaine/epinephrine may interact with several drug classes.

Major Interactions (Avoid)

  • MAO inhibitors: may cause hypertensive crisis with epinephrine.
  • Class I antiarrhythmics (e.g., quinidine): increase lidocaine toxicity.
  • Beta‑blockers: may potentiate epinephrine‑induced hypertension.

Moderate Interactions (Monitor Closely)

  • Tricyclic antidepressants: may raise lidocaine plasma concentrations.
  • CYP3A4 inhibitors (e.g., erythromycin): may reduce lidocaine clearance.
  • Non‑steroidal anti‑inflammatory drugs: may increase bleeding risk due to vasoconstriction.

Frequently Asked Questions

Lidocaína + Adrenalina Normogen is an injectable combination of lidocaine and epinephrine used to provide local anesthesia for infiltration and perineural (nerve block) techniques during minor surgical, dental, and dermatologic procedures.

Lidocaine blocks voltage‑gated sodium channels on neuronal membranes, preventing depolarisation and halting nerve impulse transmission, which results in loss of sensation in the targeted area.

The appropriate dose is determined by the prescribing clinician based on the procedure, patient characteristics, and safety guidelines. Dosage is individualized and should follow local medical standards.

Safety data in pregnancy and lactation are limited. Use only if the potential benefit justifies any potential risk to the fetus or infant, and after consultation with a qualified healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Compared with plain lidocaine, the addition of epinephrine provides vasoconstriction, which reduces systemic absorption, prolongs the anesthetic effect, and decreases intra‑operative bleeding. This can be advantageous over non‑vasoconstricted formulations for longer procedures.

Store the injectable solution at ambient temperature, preferably below 25 °C, in its original packaging. Protect from direct sunlight, moisture, and extreme temperature fluctuations to maintain potency.

The product is administered by a qualified healthcare professional via infiltration or perineural injection. The injection site is prepared aseptically, and the volume is injected slowly to minimise discomfort and ensure proper distribution.

Serious adverse events include severe allergic reactions (anaphylaxis), cardiac arrhythmias, seizures from excessive lidocaine levels, and rare cases of methemoglobinemia. Immediate medical attention is required if any of these occur.

Patients with known hypersensitivity to lidocaine, epinephrine, or any component of the formulation should avoid use. Caution is also advised for individuals with uncontrolled hypertension, significant cardiac disease, or those taking interacting medications such as MAO inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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