Product image of Nexium Φακελίσκοσ (Esomeprazole) supplied by GNH India

Nexium Φακελίσκοσ

Active Ingredient:
Esomeprazole
Origin:
EU

Nexium Φακελίσκοσ (Esomeprazole)

Esomeprazole, the active ingredient in Nexium Φακελίσκοσ, is a proton pump inhibitor presented as an oral dosage form for oral use. It reduces gastric acid production and is used to treat conditions such as gastro‑oesophageal reflux disease, erosive esophagitis, peptic ulcer disease and as part of Helicobacter pylori eradication regimens in adult patients.

GNH India supplies Nexium Φακελίσκοσ as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

C.G.Papaloisou Ltd

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Indications & Clinical Uses

Esomeprazole acts on the gastric acid‑secretion pathway and is indicated for several acid‑related disorders.

  • Gastro‑oesophageal reflux disease (GERD): reduces acid exposure and promotes healing of the oesophageal mucosa.
  • Erosive esophagitis: facilitates ulcer healing and symptom relief.
  • Peptic ulcer disease: supports ulcer closure and prevents recurrence.
  • Helicobacter pylori eradication: used in combination therapy to improve eradication rates.

How It Works

  • Esomeprazole selectively and irreversibly inhibits the H+/K+ ATPase enzyme (the gastric proton pump) located on the secretory surface of parietal cells. By blocking this final step of acid secretion, it markedly lowers both basal and stimulated gastric acid output, leading to an increased gastric pH and reduced acidity in the stomach.

Side Effects

Adverse reactions may occur with esomeprazole therapy.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Diarrhoea: loose stools occurring intermittently.
  • Nausea: sensation of stomach upset.
  • Abdominal pain: discomfort in the upper abdomen.
  • Flatulence: increased intestinal gas.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Clostridioides difficile infection: persistent diarrhoea with abdominal pain.
  • Low magnesium levels: muscle cramps, weakness, or irregular heartbeat.
  • Elevated liver enzymes: signs of hepatic stress.
  • Stevens‑Johnson syndrome: severe skin blistering.
  • Acute pancreatitis: sudden upper abdominal pain with nausea.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Renal function assessment: adjust use in patients with severe impairment.
  • Elderly patients: monitor for increased sensitivity to side effects.
  • Long‑term use: evaluate necessity regularly to avoid unnecessary exposure.
  • Magnesium monitoring: check levels during prolonged therapy.
  • Concomitant medication review: assess for potential interactions.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Esomeprazole may affect the pharmacokinetics of several drugs.

Major Interactions (Avoid)

  • Clopidogrel: reduced antiplatelet effect, increasing clot risk.
  • Atazanavir: decreased antiviral absorption, compromising efficacy.
  • Ketoconazole: markedly reduced antifungal absorption.

Moderate Interactions (Monitor Closely)

  • Digoxin: increased serum concentrations, risk of toxicity.
  • Methotrexate: elevated levels may enhance toxicity, especially at high doses.

Frequently Asked Questions

Nexium Φακελίσκοσ contains esomeprazole, which is prescribed to manage gastro‑oesophageal reflux disease, heal erosive esophagitis, treat peptic ulcer disease and serve as part of combination therapy for Helicobacter pylori eradication. It works by lowering stomach acidity, thereby relieving symptoms and promoting mucosal healing.

Esomeprazole blocks the gastric H+/K+ ATPase enzyme, also known as the proton pump, located on the surface of stomach parietal cells. This inhibition stops the final step of acid production, leading to a sustained reduction in gastric acid secretion and an increase in gastric pH.

The appropriate dose of Nexium Φακελίσκοσ is determined by a qualified prescriber based on the specific indication, patient age, renal function and other clinical factors. Patients should follow the dosing instructions provided by their healthcare professional.

Safety data for esomeprazole in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any potential risk to the fetus or infant, and this decision must be made by a healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Esomeprazole is the S‑enantiomer of omeprazole and generally provides more consistent acid suppression than racemic PPIs. Compared with H2‑receptor antagonists, it offers longer duration of action and greater efficacy for severe acid‑related conditions, though individual response may vary.

Store at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Nexium Φακελίσκοσ is taken orally, usually with a glass of water. It may be taken with or without food, but patients should follow the specific instructions given by their prescriber regarding timing relative to meals.

Serious adverse events, although rare, include severe allergic reactions, Clostridioides difficile‑associated diarrhoea, low magnesium levels, liver enzyme elevations, Stevens‑Johnson syndrome and acute pancreatitis. Patients should seek immediate medical attention if they experience symptoms such as rash, persistent diarrhoea, muscle cramps, jaundice or severe abdominal pain.

Patients with known hypersensitivity to esomeprazole or any component of the formulation should avoid the product. Caution is also advised for individuals with severe liver disease, those on certain interacting medications, and patients requiring long‑term acid suppression without clear indication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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