Gynoflor® (Estriol, Lactobacillus Acidophilus, Lyophilized)

Gynoflor® is indicated for the local treatment of estrogen‑deficient conditions of the vagina that commonly occur after menopause.

• Relief of vulvovaginal atrophy symptoms such as dryness, itching, and burning.
• Management of genitourinary syndrome of menopause, including dyspareunia and urinary irritation.
• Restoration of a normal vaginal microbiome through probiotic activity.
• Improvement of vaginal epithelial maturation and lubrication.
• Adjunct therapy after systemic hormone replacement when localized effect is preferred.

Side effects of Gynoflor® are generally mild and related to its local estrogen or probiotic components, and they usually resolve without medical intervention.

Common

• Mild vaginal irritation or spotting after insertion.
• Transient increase in vaginal discharge.
• Temporary mild abdominal cramping.
• Slight burning sensation during intercourse that diminishes with continued use.
• Mild itching of the vulvar area.

Serious

• Signs of estrogen excess such as breast tenderness or swelling.
• Unexplained vaginal bleeding.
• Allergic reaction with rash, itching, or swelling of the face.
• Severe pelvic pain or persistent headache.

Before using Gynoflor® patients should consider several precautions to ensure safe and effective therapy.

• Use only as prescribed; it is a prescription‑only product.
• Do not use if you have a known hypersensitivity to estriol or Lactobacillus acidophilus.
• Avoid prolonged continuous use beyond the recommended treatment cycle without medical review.
• Women with a history of estrogen‑dependent neoplasia should discuss risks with their clinician.
• Not recommended during pregnancy or lactation unless specifically advised by a healthcare professional.
• Monitor for any unexpected vaginal bleeding and report it promptly.

Gynoflor® may interact with other medications or products that influence estrogen activity or vaginal environment.

Avoid

• Systemic estrogen therapy (e.g., oral estradiol) that could increase overall estrogen exposure.
• Antifungal or antibacterial vaginal products used concurrently, which may disrupt probiotic colonization.
• Hormonal contraceptives containing estrogen if combined systemic estrogen is not indicated.
• Topical estrogen creams applied to the same area, which could lead to excess local estrogen.

Use with caution

• Oral selective estrogen receptor modulators (SERMs) such as tamoxifen.
• Anticoagulant therapy, as estrogen can affect clotting factors.
• Systemic corticosteroids, which may alter mucosal healing.
• Antibiotics that may affect the vaginal microbiome, potentially reducing probiotic efficacy.