Lipiodol Ultra Fluído (Ethyl Esters Of Iodised Fatty Acids From Poppyseed Oil)

Lipiodol Ultra Fluído is an iodinated oil‑based contrast medium used in radiographic procedures that require high‑density imaging of vascular and lymphatic systems.

• Lymphangiography: enables detailed visualization of lymphatic vessels and nodes for diagnostic assessment.
• Hepatic artery embolization: provides radiopaque guidance during embolization procedures to treat liver tumors.
• Radiographic imaging: enhances contrast of vascular structures in fluoroscopic or CT studies for improved diagnostic accuracy.

• The ethyl esters of iodised fatty acids contain a high concentration of iodine atoms, which strongly absorb X‑ray photons. When administered intra‑arterially, intralymphatically, or intramuscularly, the oil‑based suspension remains within the vascular or lymphatic lumen, creating a radiopaque outline that delineates anatomical structures and pathological lesions during imaging.

Adverse reactions may occur following administration of Lipiodol Ultra Fluído.

Common Side Effects

• Pain at injection site: mild to moderate discomfort.
• Transient fever: short‑lasting temperature elevation.
• Nausea or vomiting: occasional gastrointestinal upset.
• Headache: mild to moderate intensity.
• Mild allergic reaction: rash or itching.
• Local swelling: temporary edema at injection area.

Serious or Rare Side Effects

• Severe allergic reaction (anaphylaxis): respiratory distress, hypotension.
• Oil embolism: pulmonary or systemic embolic events.
• Thyroid dysfunction: hyper‑ or hypothyroidism due to iodine load.
• Renal impairment: decreased kidney function in susceptible patients.
• Organ toxicity: hepatic or cardiac effects in rare cases.
• Death: extremely rare but reported in severe embolic events.

Prior to using Lipiodol Ultra Fluído, clinicians should consider several safety measures.

• Assess iodine allergy: avoid in patients with known hypersensitivity to iodine‑containing agents.
• Monitor thyroid function: iodine load may alter hormone levels, especially in patients with thyroid disease.
• Evaluate renal function: use cautiously in patients with impaired kidney function.
• Use aseptic technique: prevent infection at the injection site.
• Store at room temperature: keep in original container, protect from light and moisture.

Lipiodol Ultra Fluído may interact with other medications that affect iodine balance or renal function.

Major Interactions (Avoid)

• Iodine‑containing medications: increased total iodine load may cause thyroid dysfunction.
• Radioactive iodine therapy: may interfere with therapeutic uptake.
• Thyroid hormone replacement: dosage may need adjustment due to iodine exposure.
• High‑osmolar contrast agents: combined use raises risk of renal toxicity.
• Certain anticoagulants: may increase bleeding risk at injection site.

Moderate Interactions (Monitor Closely)

• Nephrotoxic drugs (e.g., aminoglycosides, NSAIDs): monitor renal parameters.
• Diuretics: may affect fluid balance during imaging procedures.
• Beta‑blockers: may mask symptoms of contrast‑induced hypertension.